Yak milk ameliorates chronic alcohol-induced brain injury in mice by modulating the gut microbiota and suppressing the TLR4/NF-κB pathway

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Food Funct., 2025
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Identification of SNCA and DRD2 as key genes linking parkinson’s disease and circadian rhythm through bioinformatics analysis

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Sci Rep, 2025, 15
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Antioxidative role of Traditional Chinese Medicine in Parkinson's disease

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Journal of Ethnopharmacology, 2022, 285, 114821
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Regulation and mechanism of Astragalus polysaccharide on ameliorating aging in Drosophila melanogaster

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International Journal of Biological Macromolecules, 2023, 234, 123632
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Nicotine Has a Therapeutic Window of Effectiveness in a Drosophila melanogaster Model of Parkinson’s Disease

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The antioxidant effects of hedysarum polybotrys polysaccharide in extending lifespan and ameliorating aging-related diseases in Drosophila melanogaster

Shipei Yang, Minghui Xiu, Xu Li, Yan Shi, Shuwei Wang, Shengfang Wan, Shuzhen Han, Dan Yang, Yongqi Liu and Jianzheng He

International Journal of Biological Macromolecules, 2023, 241, 124609
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GLUT4 mediates the protective function of gastrodin against pressure overload-induced cardiac hypertrophy

Miao Zhang, Yanzhen Tan, Yujie Song, Min zhu, Bing Zhang, Cheng Chen, Yingying Liu, Lei Shi, Jun Cui, Wenju Shan, Zipei Jia, Lele Feng, Guojie Cao, Wei Yi and Yang Sun

Biomedicine & Pharmacotherapy, 2023, 161, 114324
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Gastrodin inhibits hexokinase-2 mediated glycolysis to rescue rotenone-damaged PC12 cells

Min Chen, Jiaming Tian, Buyun Jia, Meng Wang, Anqi Han, Jiming Zhu, Shasha Tian, Xiaoming Gao, Baikun Li, Qinglin Li and Shanshan Li

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Gastrodin Improves the Activity of the Ubiquitin–Proteasome System and the Autophagy–Lysosome Pathway to Degrade Mutant Huntingtin

He Sun, Miao Li, Yunling Li, Na Zheng, Jiaxin Li, Xiang Li, Yingying Liu, Qianyun Ji, Liping Zhou, Jingwen Su, Wanxu Huang, Zhongbo Liu, Peng Liu and Libo Zou

IJMS, 2024, 25, 7709
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Study on the uptake of Gastrodin in the liver

Xing Wang, Wenzhu Yang, Jitong Lv and Xinya Liao

Heliyon, 2024, 10, e36031
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Gastrodin ameliorates oxidative stress-induced RPE damage by facilitating autophagy and phagocytosis through PPARα-TFEB/CD36 signal pathway

Chaojuan Wen, Xinyue Yu, Jingya Zhu, Jingshu Zeng, Xielan Kuang, Youao Zhang, Shiyu Tang, Qingjiong Zhang, Jianhua Yan and Huangxuan Shen

Free Radical Biology and Medicine, 2024, 224, 103
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The traditional uses, phytochemistry and pharmacology of Gastrodia elata Blume: A comprehensive review

Yingfeng Zhong, Jieqing Li, Honggao Liu and Yuanzhong Wang

Arabian Journal of Chemistry, 2025, 18, 106086
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The Potentiality of Natural Products and Herbal Medicine as Novel Medications for Parkinson’s Disease: A Promising Therapeutic Approach

Yu-Jin So, Jae-Ung Lee, Ga-Seung Yang, Gabsik Yang, Sung-Wook Kim, Jun-Ho Lee and Jong-Uk Kim

IJMS, 2024, 25, 1071
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Gastrodin: a comprehensive pharmacological review

Yulin Wang, Mengting Bai, Xian Wang, Zhaolei Peng, Chunyan Cai, Jingjing Xi, Chunmei Yan, Jia Luo and Xiaofang Li

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The effects of bioactive components from the rhizome of gastrodia elata blume (Tianma) on the characteristics of Parkinson’s disease

Changcheng Lu, Shuhui Qu, Zhangfeng Zhong, Hua Luo, Si San Lei, Hai-Jing Zhong, Huanxing Su, Yitao Wang and Cheong-Meng Chong

Front. Pharmacol., 2022, 13
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Exploring the Efficient Natural Products for the Therapy of Parkinson’s Disease via Drosophila Melanogaster (Fruit Fly) Models

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CDT, 2024, 25, 77
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Gastrodin ameliorates synaptic impairment, mitochondrial dysfunction and oxidative stress in N2a/APP cells

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RhoA/ROCK2 signaling pathway regulates Mn-induced alterations in tight junction proteins leading to cognitive dysfunction in mice

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Current Research in Toxicology, 2025, 8, 100207
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Studies on the Regulation and Molecular Mechanism of Panax Ginseng Saponins on Senescence and Related Behaviors of Drosophila melanogaster

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Comparative Phytochemical Analysis of Gastrodiae Rhizoma Peel and Core and Their Lifespan-Extending Potential in Caenorhabditis elegans

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Regulation of mitophagy and mitochondrial function: Natural compounds as potential therapeutic strategies for Parkinson's disease

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Targeting the Nrf2 signaling pathway using phytochemical ingredients: A novel therapeutic road map to combat neurodegenerative diseases

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Phytomedicine, 2023, 109, 154582
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Gastrodin and Vascular Dementia: Advances and Current Perspectives

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Evidence-Based Complementary and Alternative Medicine, 2022, 2022, 1
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Review on pharmacological effects of gastrodin

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E-eye and FT-NIR combined with multivariate algorithms to rapidly evaluate the dynamic changes in the quality of Gastrodia elata during steaming process

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The Therapeutic Potential of Hemp Seed Oil in D-Galactose-Induced Aging Rat Model Was Determined through the Combined Assessment of 1H NMR Metabolomics and 16S rRNA Gene Sequencing

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Gastrodin Ameliorates Learning and Memory Impairments Caused by Long-Term Noise Exposure

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Effects of Silibinin on Delaying Aging in Drosophila melanogaster

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Antioxidants, 2025, 14, 147
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Using Drosophila melanogaster as a suitable platform for drug discovery from natural products in inflammatory bowel disease

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Front. Pharmacol., 2022, 13
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Proanthocyanidins supplemented diet alter anti-aging-markers and improved lifespan in Drosophila melanogaster model

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Plant-based strategies against aging: Focus on bioactive compounds from medicine-food homology plants

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Gastrodin ameliorates the lipopolysaccharide-induced neuroinflammation in mice by downregulating miR-107-3p

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Protective effect of astragalus membranaceus and its bioactive compounds against the intestinal inflammation in Drosophila

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Front. Pharmacol., 2022, 13
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Gastrodin regulates H3K14la through the CDT2-KAT2A axis to treat Sepsis-induced myocardial dysfunction

Huiming Yu, Qianqian Du, Jiaqin Wu, Fan Feng, Shuwan Hou, Minfu Liu, Sixiang Wang, Xianqiong Liu, Chunli Wang and Kang Xu

International Immunopharmacology, 2025, 161, 115065
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Therapeutic potential of Astragalus membranaceus—Pueraria lobata decoction for the treatment of chemotherapy bowel injury

Yixuan Wang, Yujie Qin, Qian Kang, Huinan Wang, Shihong Zhou, Yifan Wu, Yongqi Liu, Yun Su, Yaqiong Guo, Minghui Xiu and Jianzheng He

The FASEB Journal, 2024, 38
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Unlocking nature’s medicine cabinet through Drosophila–Driven exploration

Xiao Sheng, Jianzheng He and Lei Zhang

Phytomedicine, 2025, 146, 157123
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Exposure to cytarabine causes side effects on adult development and physiology and induces intestinal damage via apoptosis in Drosophila

Shuzhen Han, Minghui Xiu, Shuang Li, Yan Shi, Xiaoqian Wang, Xingyao Lin, Hui Cai, Yongqi Liu and Jianzheng He

Biomedicine & Pharmacotherapy, 2023, 159, 114265
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The protective effect and bioactive compounds of Astragalus membranaceus against neurodegenerative disorders via alleviating oxidative stress in Drosophila

Yuting Dai, Yixuan Wang, Qian Kang, Yifan Wu, Yongqi Liu, Yun Su, Xinhua Wang, Minghui Xiu and Jianzheng He

The FASEB Journal, 2024, 38
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Gastrodin inhibits prostate cancer proliferation by targeting canonical Wnt/β-catenin signaling pathway

Ye-Mao Liu, An-Ding Wu, Yun Chen, Teng-Fei Ma, Bi-Zhen Dong, Zhi-Gang She, Mao-Lin Yi and Wei-Ming Mao

Med Oncol, 2023, 41
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Targeting protein kinases in Parkinson’s disease: the emerging role of phytoconstituents

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Nutritional Neuroscience, 2025, 1
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Phenolamides from Rootstocks of Lycium ruthenicum Murr by Ligand Fishing and Their Neuroprotective Effects

Yi-Kao Hu, Ayzohra Ablat, Xiao-Lin Bai, Xiang Yin, Chao Ma and Xun Liao

J. Agric. Food Chem., 2025, 73, 8944
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The role of gastrodin in the management of CNS‐related diseases: Underlying mechanisms to therapeutic perspectives

Xirui He, Xufei Chen, Yan Yang, Jingyi Gu, Yulu Xie, Yujie Liu, Man Hao and Michael Heinrich

Phytotherapy Research, 2024, 38, 5107
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Chemistry, Biological Activities, and Pharmacological Properties of Gastrodin: Mechanism Insights

Naoual El Menyiy, Youssef Elouafy, Rania Moubachir, Rhizlan Abdnim, Taoufiq Benali, Douae Taha, Asaad Khalid, Ashraf N. Abdalla, Siddiqa M. A. Hamza, Salma Elhadi Ibrahim, Mohamed El‐Shazly, Gokhan Zengin and Abdelhakim Bouyahya

Chemistry & Biodiversity, 2024, 21
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FT-NIR and ATR-FTIR spectroscopy combined with machine learning for accurate identification of variants and hybrids of Gastrodia elata Blume

Duo Han, Honggao Liu and Yuanzhong Wang

Microchemical Journal, 2025, 216, 114725
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Parishin From Gastrodia Elata Ameliorates Aging Phenotype in Mice in a Gut Microbiota-Related Manner

Xinxiu Zhao, Shixian Zhou, Ren Yan, Caixia Gong, Qifeng Gui, Qin Zhang, Lan Xiang, Lufang Chen, Peixia Wang, Shumin Li and Yunmei Yang

Front. Microbiol., 2022, 13
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A network-based pharmacological study of the network mechanism of Rhizoma Gastrodiae for Parkinson’s disease

Lei Wan

ND, 2024, 1
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Dunhuang Dabupi Decoction and its active components alleviate ulcerative colitis by activating glutathione metabolism and inhibiting JAK-STAT pathway in Drosophila and mice

Li He, Yongxuan Zhang, Jiangnan Li, Dandan Chen, Shiqi Yue, Yongqi Liu, Yaqiong Guo, Yan Wang, Minghui Xiu and Jianzheng He

Journal of Ethnopharmacology, 2025, 346, 119717
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Gastrodin attenuates high fructose-induced sweet taste preference decrease by inhibiting hippocampal neural stem cell ferroptosis

Chuan-Feng Tang, Hong Ding, Ya-Qian Wu, Zi-An Miao, Zi-Xuan Wang, Wen-Xuan Wang, Ying Pan and Ling-Dong Kong

Journal of Advanced Research, 2025, 74, 429
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Preparation of gastrodin modified P(VDF-TrFE)-Eudragit L100-AuNPs nanofiber membranes with piezoelectric property

Wen Shen, Shang Wu, Xuemei Ge, Fen Ao, Yueyang Mao, Jiaru Hu and Pi Yan

Journal of the Mechanical Behavior of Biomedical Materials, 2024, 151, 106355
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Proteomic Analysis for Neuroprotective Effect of Gastrodia elata Blume in the Substantia Nigra of Mice

Chang-Hwan Bae, Hee-Young Kim, Hanul Lee, Ji Eun Seo, Dong Hak Yoon and Seungtae Kim

Korean J Acupunct, 2022, 39, 142
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Mitochondrial quality control disorder in neurodegenerative disorders: Potential and advantages of traditional Chinese medicines

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Journal of Pharmaceutical Analysis, 2025, 15, 101146
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A comprehensive pharmacology study reveals the molecular mechanisms underlying the antidepressant effects of Gastrodiae Rhizoma

Pei Liu, Zhihuang Zhao, Haili Zhang, Chenghong Xiao, Meidan Wang, Chengyan Yang, Yu-e Liu, Lulu Wang, Hui He, Yangyan Ge, Yan Fu, Tao Zhou, Zili You and Jinqiang Zhang

Phytomedicine, 2025, 142, 156761
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A Novel Gastrodin Derivative with Neuroprotection Promotes NGF-Mimic Activity by Targeting INSR and ACTN4 to Activate PI3K/Akt Signaling Pathway in PC12 Cells

Jiayuan Zeng, Jianxia Mo, Makoto Muroi, Hiroyuki Osada, Lan Xiang and Jianhua Qi

Antioxidants, 2025, 14, 344
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Regulation and mechanism of Bletilla striata polysaccharide on delaying aging in Drosophila melanogaster

Eqra Hafeez, Dongsheng Du, Hang Ni, Kai Zhu, Fan Hu, Jihai Zhou and Dongsheng Chen

International Journal of Biological Macromolecules, 2025, 310, 143382
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Immunometabolism and oxidative stress: roles and therapeutic strategies in cancer and aging

Nan-jie Zhou, Wei-Qian Bao, Cui-fen Zhang, Meng-Lin Jiang, Tu-Liang Liang, Gang-Yuan Ma, Liang Liu, Hu-Dan Pan and Run-Ze Li

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Focused Ultrasound Promotes the Delivery of Gastrodin and Enhances the Protective Effect on Dopaminergic Neurons in a Mouse Model of Parkinson’s Disease

Yuhong Wang, Kaixuan Luo, Junrui Li, Yehui Liao, Chengde Liao, Wen-Shiang Chen, Moxian Chen and Lijuan Ao

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Decoding mitochondrial quality control mechanisms: Identifying treatment targets for enhanced cellular health

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Neuroprotective Effects of Lycium Barbarum Fruit Extract on Pink1B9Drosophila Melanogaster Genetic Model of Parkinson’s Disease

Xiao-Lin Bai, Ying-Jie Luo, Wen-Qin Fan, Yong-Mei Zhang and Xun Liao

Plant Foods Hum Nutr, 2023, 78, 68
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