The effects of phenolic acid supplementation on intestinal barrier function: a review

Li Xia, Xiulian Lin, Yuanjiao Zhou, Yamei Li, Yingyan Liao, Yan Lin, Limei Lin, Ping Wu and Jingchen Xie

Food Funct., 2026, 17, 41
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Melatonin Ameliorates Diquat-Induced Testicular Toxicity via Reducing Oxidative Stress, Inhibiting Apoptosis, and Maintaining the Integrity of Blood-Testis Barrier in Mice

Li Yang, Jianyong Cheng, Dejun Xu, Zelin Zhang, Rongmao Hua, Huali Chen, Jiaxin Duan, Xiaoya Li and Qingwang Li

Toxics, 2023, 11, 160
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Kaempferol and ginsenoside Rg1 ameliorate acute hypobaric hypoxia induced lung injury based on network pharmacology analysis

Na Li, Yuan Cheng, Tao Jin, Lirui Cao, Jieyu Zha, Xiong Zhu and Qing He

Toxicology and Applied Pharmacology, 2023, 480, 116742
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Effect of selenium yeast supplementation on drug metabolism genes, oxidative stress, and apoptosis in chicken liver after diquat induction: A proteomic perspective

Fan Gao, Xiaoxiao Yang, Xunhao Zhu, Yalin Wu, Ben Liu, Wenya Zheng, Songlin Ding, Lucheng Zheng, Wei Hu, Xue Yang, Manxin Fang and Qingcan Fan

Poultry Science, 2026, 105, 106469
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Effects of dietary supplementation with chlorogenic acid on growth performance, antioxidant capacity, and hepatic inflammation in broiler chickens subjected to diquat-induced oxidative stress

Pingping Zha, Leyi Wei, Wenhan Liu, Yueping Chen and Yanmin Zhou

Poultry Science, 2023, 102, 102479
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Hua-Tan-Sheng-Jing Decoction Treats Obesity With Oligoasthenozoospermia by Up-Regulating the PI3K-AKT and Down-Regulating the JNK MAPK Signaling Pathways: At the Crossroad of Obesity and Oligoasthenozoospermia

Yang Dong, Yanfei Zheng, Linghui Zhu, Tianxing Li, Yuanyuan Guan, Shipeng Zhao, Qi Wang, Ji Wang and Lingru Li

Front. Pharmacol., 2022, 13
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Preparation, characterization, and evaluation of the antitumor effect of kaempferol nanosuspensions

Wen He, Junfeng Zhang, Jiale Ju, Yinghua Wu, Yuxi Zhang, Lin Zhan, Chenchen Li and Yanli Wang

Drug Deliv. and Transl. Res., 2023, 13, 2885
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Selenomethionine and Allicin Synergistically Mitigate Intestinal Oxidative Injury by Activating the Nrf2 Pathway

Yongshi Liu, Xi Lv, Heling Yuan, Xiaoming Wang, Jinhu Huang and Liping Wang

Toxics, 2024, 12, 719
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In vitro inhibitory effects of polyphenols from Tartary buckwheat on xanthine oxidase: Identification, inhibitory activity, and action mechanism

Jun Li, Yuhong Gong, Jinwei Li and Liuping Fan

Food Chemistry, 2022, 379, 132100
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In Vitro Evaluation of Kaempferol-Loaded Hydrogel as pH-Sensitive Drug Delivery Systems

Qin Zhang, Xinying Yang, Yifang Wu, Chang Liu, Hongmei Xia, Xiaoman Cheng, Yongfeng Cheng, Ying Xia and Yu Wang

Polymers, 2022, 14, 3205
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Effect of free and bound polyphenols from Rosa roxburghii Tratt distiller's grains on moderating fecal microbiota

Die Zhou, Jiang Zhong, Yongguang Huang and Yuxin Cheng

Food Chemistry: X, 2023, 19, 100747
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Gastrointestinal digestion behavior and bioavailability of greenly prepared highly loaded myofibrillar-luteolin vehicle

Zhenyang Wu, Weiyi Zhang, Xue Zhao and Xinglian Xu

Food Research International, 2024, 187, 114413
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Oxidative stress in Wernicke’s encephalopathy

Jun-Dong Wei and Xueming Xu

Front. Aging Neurosci., 2023, 15
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The in vitro anti-inflammatory mechanism of Porphyra haitanensis oligosaccharides on lipopolysaccharide-induced injury in IEC-6 cells

Si-Min Qiu, Suresh Veeraperumal, Karsoon Tan, Saiyi Zhong and Kit-Leong Cheong

Journal of Functional Foods, 2024, 112, 106005
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Consensus gene co-expression analysis across multiple intestinal tissues to identify key genes and pathways associated with abdominal fat deposition in broilers

S. Wang, Y. Liu, S. Liu, Z. Qin, J. Lu, R. Zhang and H. Yuan

British Poultry Science, 2025, 66, 155
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Trans-anethole ameliorates LPS-induced inflammation via suppression of TLR4/NF-κB pathway in IEC-6 cells

Caiyun Yu, Dong Wang, Qiming Li, Yichun Tong, Zaibin Yang and Tian Wang

International Immunopharmacology, 2022, 108, 108872
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Kaempferol alleviates bisphenol A reproductive toxicity in rats in a dose-dependent manner

Inas Molayousefian, Bardia Karim, Seyed Mohammad Hosseini, Ali Akbar Moghadamnia and Sohrab Kazemi

Biochemical and Biophysical Research Communications, 2024, 704, 149674
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Fermentation of Robinia pseudoacacia flower for improving the antioxidation: optimized conditions, active composition, mechanism, and biotransformation process

Yi Yang, Yunci Zhang, Dongyu Gu, Chang Liu, Yi Wang, Shanshan Tang, Yuxin Yin and Jing Tian

Preparative Biochemistry & Biotechnology, 2023, 53, 1224
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Caffeic acid improves intestinal barrier function integrity through activation of Nrf2 signaling pathway in weaned piglets and H2O2 induced IPEC-J2 cells

Xueya Zhu, Tianlei Qiao, Zhiqing Huang, Gang Jia, Hua Zhao and Xiaoling Chen

The Journal of Nutritional Biochemistry, 2025, 143, 109952
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Flavonoids in Treatment of Chronic Kidney Disease

Yi-Ling Cao, Ji-Hong Lin, Hans-Peter Hammes and Chun Zhang

Molecules, 2022, 27, 2365
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A Critical Review of Kaempferol in Intestinal Health and Diseases

Jun Chen, Haopeng Zhong, Zhouyin Huang, Xingping Chen, Jinming You and Tiande Zou

Antioxidants, 2023, 12, 1642
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Identification of Key Genes Associated With Epithelial Barrier Dysfunction by Comprehensive Analysis and Experimental Validation

Shixiu Liang, Meihua Dong, Xiaodi Zhu, Siqi Wang, Sitong Lin, Yanwen Li, Shiting Yi, Di Wu, Zhaowei Yang, Yingjun Chen and Jing Li

Allergy, 2026
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Lacticaseibacillus rhamnosus 1.0320 isolated from fermented kumis combined with 3-Fucosyllactose and 3′-Sialyllactose ameliorates LPS-induced intestinal epithelial barrier dysfunction by inhibiting the NF-κB pathway and activating the Nrf2 pathway

Xiaolei Duan, Hao Shi, Mingzhang Zhao, Zhanmei Jiang, Jing Zhang, Xianhui Chen, He Zhang, Juncai Hou and Xiangyu Li

International Dairy Journal, 2026, 175, 106545
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Regulation of reactive oxygen species by phytochemicals for the management of cancer and diabetes

Heui Min Lim and See-Hyoung Park

Critical Reviews in Food Science and Nutrition, 2023, 63, 5911
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Polyphenols from sauce-flavor distiller’s grains: Improving the fecal microbial structure and intestinal barrier function

Lijuan Lu and Yuxin Cheng

Food Research International, 2026, 229, 118465
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Plant-derived squalene supplementation improves growth performance and alleviates acute oxidative stress-induced growth retardation and intestinal damage in piglets

Junquan Tian, Qian Jiang, Xuetai Bao, Fan Yang, Yuying Li, Haihui Sun, Kang Yao and Yulong Yin

Animal Nutrition, 2023, 15, 386
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Pharmacological Effects of Polyphenol Phytochemicals on the Intestinal Inflammation via Targeting TLR4/NF-κB Signaling Pathway

Caiyun Yu, Dong Wang, Zaibin Yang and Tian Wang

IJMS, 2022, 23, 6939
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Probing the molecular mechanism of kaempferol in relieving rheumatoid arthritis based on network pharmacology

Haomiao Liu, Huangying Lu, Xuefei Fan, Suhuan Chen, Xiaoyu Chen and Weilu Gao

Sci Rep, 2025, 15
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Kaempferol, a widely ingested dietary flavonoid and supplement, enhances biological performance via hormesis, especially for ageing-related processes

Edward J. Calabrese, Peter Pressman, A. Wallace Hayes, Linda Baldwin, Evgenios Agathokleous, Harshita Kapoor, Gaurav Dhawan, Rachna Kapoor and Vittorio Calabrese

Mechanisms of Ageing and Development, 2025, 225, 112065
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Adipose-derived stem cells promote the recovery of intestinal barrier function by inhibiting the p38 MAPK signaling pathway

Mei Yang, Wangbin Xu, Chaofu Yue, Rong Li, Xian Huang, Yongjun Yan, Qinyong Yan, Shisheng Liu, Yuan Liu and Qiaolin Li

Eur J Histochem, 2025, 69
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Difenoconazole disrupts carp intestinal physical barrier and causes inflammatory response via triggering oxidative stress and apoptosis

Xinyu Wu, Hairui Han, Kunmei Xie, Nana He, Zuwang Yang, Xiaohui Jin, Shaojie Ma and Jingquan Dong

Pesticide Biochemistry and Physiology, 2023, 194, 105507
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Prognosis prediction of procalcitonin within 24 h for acute diquat poisoning

Cheng He, Liguo Liang, Yu Zhang, Tianyi Wang and Rongyang Wang

BMC Emerg Med, 2024, 24
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Pharmacological Potential of Kaempferol, a Flavonoid in the Management of Pathogenesis via Modulation of Inflammation and Other Biological Activities

Faris Alrumaihi, Saleh A. Almatroodi, Hajed Obaid A. Alharbi, Wanian M. Alwanian, Fadiyah A. Alharbi, Ahmad Almatroudi and Arshad Husain Rahmani

Molecules, 2024, 29, 2007
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Kaempferol inhibits lipid accumulation in alcoholic fatty liver disease through PRMT-1-mediated arginine methylation of SCD1

Jiahui Li, Zheng Zhou and Qiaoling Zhou

J Antibiot, 2025, 78, 686
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Three Strains of Lactobacillus Derived from Piglets Alleviated Intestinal Oxidative Stress Induced by Diquat through Extracellular Vesicles

Shengkai Feng, Yihan Liu, Jing Xu, Jinping Fan, Jingjing Li, Zhifeng Wu, Yue Sun and Wen Xiong

Nutrients, 2023, 15, 4198
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Erythrocyte membrane biomimetic EGCG nanoparticles attenuate renal injury induced by diquat through the NF-κB/NLRP3 inflammasome pathway

Jie Qu, Hui Pei, Xin-Ze Li, Yan Li, Jian-Ming Chen, Min Zhang and Zhong-Qiu Lu

Front. Pharmacol., 2024, 15
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The effect of Lonicerae flos and Rhizoma curcumae longae extract on the intestinal development and function of broilers

Dahai Xu, Xiao Wang, Xiaojiao Hou, Xiumin Wang, Wanyu Shi and Yongfei Hu

Poultry Science, 2024, 103, 104225
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Kaempferol-Driven Inhibition of Listeriolysin O Pore Formation and Inflammation Suppresses Listeria monocytogenes Infection

Tingting Wang, Baichen Liu, Can Zhang, Tianqi Fang, Ying Ding, Ge Song, Siqi Zhang, Linlin Shi, Xuming Deng, Jianfeng Wang and Katharina Schaufler

Microbiol Spectr, 2022, 10
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Vascular endothelium, a promising target for effectively treating fulminant diquat intoxication?

Xiang-Ying Cen, Yi Chen, Yong-An Xu and Guang-Yao Zhong

World J Clin Cases, 2024, 12, 2917
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Tea tree oil attenuates diquat-induced intestinal barrier dysfunction in chickens via modulating oxidative stress and gut microbiota

Gang Xu, Zihan Wang, Aili Fan, Chengkun Yu, Shuhui Ma and Yong Wang

Ecotoxicology and Environmental Safety, 2025, 303, 119028
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Rosemary (Rosmarinus officinalis L.) polyphenols and inflammatory bowel diseases: Major phytochemicals, functional properties, and health effects

Lianhua Zhang and Jie Lu

Fitoterapia, 2024, 177, 106074
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The effect of a traditional Chinese quadri-combination therapy and its component quercetin on recurrent spontaneous abortion: A clinical trial, network pharmacology and experiments-based study

Jing Zhou, Lisha Li, Xinyao Pan, Jing Wang, Qing Qi, Hongmei Sun, Chuyu Li and Ling Wang

Front. Pharmacol., 2022, 13
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Lactiplantibacillus plantarum Ameliorated Morphological Damage and Barrier Dysfunction and Reduced Apoptosis and Ferroptosis in the Jejunum of Oxidatively Stressed Piglets

Yu Liu, Junmeng Yuan, Wenshuo Xi, Zhisheng Wang, Huawei Liu, Kai Zhang, Jinshan Zhao and Yang Wang

Animals, 2024, 14, 3335
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Integrated Transcriptome and Proteome Analyses of β-Conglycinin-Induced Intestinal Damage in Piglets

Bojiang Li, Shugui Zheng, Shuangyang Yin, Jing Chen, Yu He, Jiaqi Yao and Simiao Liu

J. Agric. Food Chem., 2024, 72, 6601
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Natural and Semi-Synthetic Flavonoid Anti-SARS-CoV-2 Agents for the Treatment of Long COVID-19 Disease and Neurodegenerative Disorders of Cognitive Decline

James Melrose and Margaret M. Smith

Front. Biosci. (Elite Ed), 2022, 14
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L-theanine reduces muscle drip loss by regulating oxidative stress-mediated glycolysis disturbance and cytoskeletal protein degradation

Yu Huang, Zhiqing Huang, Gang Jia, Hua Zhao and Xiaoling Chen

Food Bioscience, 2025, 72, 107424
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Physicochemical and structural characterization coupled with untargeted metabolomics analysis of metabolic variations in different bamboo shoot powders

Yuhui Wu, Yuming You, Liangru Wu, Long Tong, Fusheng Zhang, Jinlai Yang and Jiong Zheng

LWT, 2025, 224, 117820
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Mycophenolic Acid Induces the Intestinal Epithelial Barrier Damage through Mitochondrial ROS

Yiyun Deng, Zhe Zhang, Hui Yang, Jing Wang, Lijuan Feng, Yong Su, Dujuan Xu and Ziwei Zhang

Oxidative Medicine and Cellular Longevity, 2022, 2022
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Autophagy mediated FTH1 degradation activates gasdermin E dependent pyroptosis contributing to diquat induced kidney injury

Kaiyuan Chen, Yahui Tang, Linhua Lan, Mengxuan Li and Zhongqiu Lu

Food and Chemical Toxicology, 2024, 184, 114411
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Alleviation effect of taxifolin on diquat-induced damage to porcine intestinal epithelial cells

Ke Huang, Yuting Li, Yiyu Zhang and Min Zhu

Biochemical and Biophysical Research Communications, 2025, 748, 151318
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A comprehensive and mechanistic review on protective effects of kaempferol against natural and chemical toxins: Role of NF‐κB inhibition and Nrf2 activation

Azar Hosseini, Alieh Alipour, Vafa Baradaran Rahimi and Vahid Reza Askari

BioFactors, 2023, 49, 322
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Maternal Gliadin Intake Reduces Oocyte Quality with Chromosomal Aberrations and Increases Embryonic Lethality through Oxidative Stress in a Caenorhabditis elegans Model

Jae Hyuck Lee, Mijin Lee, Hyemin Min, Esther Youn and Yhong-Hee Shim

Nutrients, 2022, 14, 5403
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Stevioside Improves Antioxidant Capacity and Intestinal Barrier Function while Attenuating Inflammation and Apoptosis by Regulating the NF-κB/MAPK Pathways in Diquat-Induced Oxidative Stress of IPEC-J2 Cells

Qinglei Xu, Mingzheng Liu, Xiaohuan Chao, Chunlei Zhang, Huan Yang, Jiahao Chen and Bo Zhou

Antioxidants, 2023, 12, 1070
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Oxidative Stress in Poultry and the Therapeutic Role of Herbal Medicine in Intestinal Health

Yuan Li, Kai Wang and Chunmei Li

Antioxidants, 2024, 13, 1375
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The Anticancer Potential of Kaempferol: A Systematic Review Based on In Vitro Studies

Everton Freitas de Morais, Lilianny Querino Rocha de Oliveira, Hannah Gil de Farias Morais, Maurília Raquel de Souto Medeiros, Roseana de Almeida Freitas, Camila Oliveira Rodini and Ricardo D. Coletta

Cancers, 2024, 16, 585
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Mitophagy and mitochondrial dynamics in type 2 diabetes mellitus treatment

Zhao Shan, Wei Hong Fa, Chen Run Tian, Chen Shi Yuan and Ning Jie

Aging, 2022, 14, 2902
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Combating Blue Light Pollution With Flavonoids: Implications for Environmental Health and Aging

Yuxin Yang, Xiangyu Li, Jianan He and Jie Shen

Arch Insect Biochem Physiol, 2026, 121
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Kaempferide Inhibits DOX-induced Liver Inflammation by Activating AMPKα/SIRT1

Qiang Li, Xing Li, Zhenchang Zhou, Pingwei Zhu, Nana Tuo, Jingli Ge, Zhaoyv Liu and Dengke Chen

Pharmacognosy Magazine, 2024, 20, 1304
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Kaemperfol Protects Dopaminergic Neurons by Promoting mTOR-Mediated Autophagy in Parkinson’s Disease Models

Zhan Liu, Wenxin Zhuang, Meiyun Cai, E. Lv, Yanqiang Wang, Zhengyan Wu, Hongyu Wang and Wenyu Fu

Neurochem Res, 2022
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Kaempferol promotes flap survival by inhibiting ferroptosis and inflammation through network pharmacology and in vivo experiments

An Wang, Jialong Yang, Jiapeng Deng, Kaitao Wang, Guodong Chen and Dingsheng Lin

Wound Repair Regeneration, 2025, 33
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Selenium yeast alleviates diquat-induced oxidative stress and testicular damage in roosters

Ningna Xiong, Sili Liu, Wei Hu, Yamei Liu, Xiang Ding, Deming Xu, Yiqiang Ling, Manxin Fang, Ben Liu, Lucheng Zheng, Wenya Zheng and Bingyan Wu

Animal Reproduction Science, 2025, 273, 107760
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Effect of Diquat on gut health: molecular mechanisms, toxic effects, and protective strategies

Cheng He, Guorong Cai, Yingmao Jia, Rong Jiang, Xiaolan Wei and Ning Tao

Front. Pharmacol., 2025, 16
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