The pearl jubilee of microcin J25: thirty years of research on an exceptional lasso peptide

Fernando Baquero, Konstantinos Beis, David J. Craik, Yanyan Li, A. James Link, Sylvie Rebuffat, Raúl Salomón, Konstantin Severinov, Séverine Zirah and Julian D. Hegemann

Nat. Prod. Rep., 2024, 41, 469
DOI: 10.1039/D3NP00046J

Matters of class: coming of age of class III and IV lanthipeptides

Julian D. Hegemann and Roderich D. Süssmuth

RSC Chem. Biol., 2020, 1, 110
DOI: 10.1039/D0CB00073F

New developments in RiPP discovery, enzymology and engineering

Manuel Montalbán-López, Thomas A. Scott, Sangeetha Ramesh, Imran R. Rahman, Auke J. van Heel, Jakob H. Viel, Vahe Bandarian, Elke Dittmann, Olga Genilloud, Yuki Goto, María José Grande Burgos, Colin Hill, Seokhee Kim, Jesko Koehnke, John A. Latham, A. James Link, Beatriz Martínez, Satish K. Nair, Yvain Nicolet, Sylvie Rebuffat, Hans-Georg Sahl, Dipti Sareen, Eric W. Schmidt, Lutz Schmitt, Konstantin Severinov, Roderich D. Süssmuth, Andrew W. Truman, Huan Wang, Jing-Ke Weng, Gilles P. van Wezel, Qi Zhang, Jin Zhong, Jörn Piel, Douglas A. Mitchell, Oscar P. Kuipers and Wilfred A. van der Donk

Nat. Prod. Rep., 2021, 38, 130
DOI: 10.1039/D0NP00027B

The role of protein–protein interactions in the biosynthesis of ribosomally synthesized and post-translationally modified peptides

Asfandyar Sikandar and Jesko Koehnke

Nat. Prod. Rep., 2019, 36, 1576
DOI: 10.1039/C8NP00064F

Rational generation of lasso peptides based on biosynthetic gene mutations and site-selective chemical modifications

Tan Liu, Xiaojie Ma, Jiahui Yu, Wensheng Yang, Guiyang Wang, Zhengdong Wang, Yuanjie Ge, Juan Song, Hua Han, Wen Zhang, Donghui Yang, Xuehui Liu and Ming Ma

Chem. Sci., 2021, 12, 12353
DOI: 10.1039/D1SC02695J

Genome Mining and Heterologous Expression Reveal Two Distinct Families of Lasso Peptides Highly Conserved in Endofungal Bacteria

Evgeni V. Bratovanov, Keishi Ishida, Beatrix Heinze, Sacha J. Pidot, Timothy P. Stinear, Julian D. Hegemann, Mohamed A. Marahiel and Christian Hertweck

ACS Chem. Biol., 2020, 15, 1169
DOI: 10.1021/acschembio.9b00805

Heterologous production of new lasso peptide koreensin based on genome mining

Hiroki Fuwa, Hikaru Hemmi, Issara Kaweewan, Ikko Kozaki, Hiroyuki Honda and Shinya Kodani

J Antibiot, 2021, 74, 42
DOI: 10.1038/s41429-020-00363-5

Lasso Peptides: Heterologous Production and Potential Medical Application

Cheng Cheng and Zi-Chun Hua

Front. Bioeng. Biotechnol., 2020, 8
DOI: 10.3389/fbioe.2020.571165

Downsizing Class II Lasso Peptides: Genome Mining-Guided Isolation of Huascopeptin Containing the First Gly1-Asp7 Macrocycle

Carlos Cortés-Albayay, Scott A. Jarmusch, Franziska Trusch, Rainer Ebel, Barbara A. Andrews, Marcel Jaspars and Juan A. Asenjo

J. Org. Chem., 2020, 85, 1661
DOI: 10.1021/acs.joc.9b02231

Structural Basis of Leader Peptide Recognition in Lasso Peptide Biosynthesis Pathway

Tomomi Sumida, Svetlana Dubiley, Brendan Wilcox, Konstantin Severinov and Shunsuke Tagami

ACS Chem. Biol., 2019, 14, 1619
DOI: 10.1021/acschembio.9b00348

Discovery and Characterization of Rubrinodin Provide Clues into the Evolution of Lasso Peptides

Huanhuan Xiu, Mengjiao Wang, Christopher D. Fage, Yile He, Xiaogang Niu, Meng Han, Fei Li, Xiaoping An, Huahao Fan, Lihua Song, Guojun Zheng, Shaozhou Zhu and Yigang Tong

Biochemistry, 2022, 61, 595
DOI: 10.1021/acs.biochem.2c00029

Substrate Specificity of the Flavoenzyme BhaC1 That Converts a C-Terminal Trp to a Hydroxyquinone

Page N. Daniels and Wilfred A. van der Donk

Biochemistry, 2023, 62, 378
DOI: 10.1021/acs.biochem.2c00206

Structure Prediction and Protein Engineering Yield New Insights into Microcin J25 Precursor Recognition

Hui-Ni Tan, Wei-Qi Liu, Josh Ho, Yi-Ju Chen, Fang-Jie Shieh, Hsiao-Tzu Liao, Shu-Ping Wang, Julian D. Hegemann, Chin-Yuan Chang and John Chu

ACS Chem. Biol., 2024, 19, 1982
DOI: 10.1021/acschembio.4c00251

Steric complementarity directs sequence promiscuous leader binding in RiPP biosynthesis

Jonathan R. Chekan, Chayanid Ongpipattanakul and Satish K. Nair

Proc. Natl. Acad. Sci. U.S.A., 2019, 116, 24049
DOI: 10.1073/pnas.1908364116

Discovery of the Class I Antimicrobial Lasso Peptide Arcumycin

Lydia M. Stariha and Dewey G. McCafferty

ChemBioChem, 2021, 22, 2632
DOI: 10.1002/cbic.202100132

Structural Insights from Tandem Mass Spectrometry, Ion Mobility-Mass Spectrometry, and Infrared/Ultraviolet Spectroscopy on Sphingonodin I: Lasso vs Branched-Cyclic Topoisomers

Kevin Jeanne Dit Fouque, Valeriu Scutelnic, Julian D. Hegemann, Sylvie Rebuffat, Philippe Maître, Thomas R. Rizzo and Francisco Fernandez-Lima

J. Am. Soc. Mass Spectrom., 2021, 32, 1096
DOI: 10.1021/jasms.1c00041

Cell-Free Mutant Analysis Combined with Structure Prediction of a Lasso Peptide Biosynthetic Protease B2

Almasul Alfi, Aleksandr Popov, Ashutosh Kumar, Kam Y. J. Zhang, Svetlana Dubiley, Konstantin Severinov and Shunsuke Tagami

ACS Synth. Biol., 2022, 11, 2022
DOI: 10.1021/acssynbio.2c00176

A Bifunctional Leader Peptidase/ABC Transporter Protein Is Involved in the Maturation of the Lasso Peptide Cochonodin I from Streptococcus suis

Julian D. Hegemann, Kevin Jeanne Dit Fouque, Miguel Santos-Fernandez and Francisco Fernandez-Lima

J. Nat. Prod., 2021, 84, 2683
DOI: 10.1021/acs.jnatprod.1c00514

Lasso peptides realm: Insights and applications

Othman Al Musaimi

Peptides, 2024, 182, 171317
DOI: 10.1016/j.peptides.2024.171317

Peptidase Activation by a Leader Peptide-Bound RiPP Recognition Element

Ashley M. Kretsch, Mayuresh G. Gadgil, Adam J. DiCaprio, Susanna E. Barrett, Bryce L. Kille, Yuanyuan Si, Lingyang Zhu and Douglas A. Mitchell

Biochemistry, 2023, 62, 956
DOI: 10.1021/acs.biochem.2c00700

Attempting to synthesize lasso peptides using high pressure

Mateusz Waliczek, Magdalena Wierzbicka, Maciej Arkuszewski, Monika Kijewska, Łukasz Jaremko, Priyadharshni Rajagopal, Kacper Szczepski, Amanda Sroczyńska, Mariusz Jaremko, Piotr Stefanowicz and Patrick van der Wel

PLoS ONE, 2020, 15, e0234901
DOI: 10.1371/journal.pone.0234901

Reactivity-Based Screening for Citrulline-Containing Natural Products Reveals a Family of Bacterial Peptidyl Arginine Deiminases

Lonnie A. Harris, Patricia M. B. Saint-Vincent, Xiaorui Guo, Graham A. Hudson, Adam J. DiCaprio, Lingyang Zhu and Douglas A. Mitchell

ACS Chem. Biol., 2020, 15, 3167
DOI: 10.1021/acschembio.0c00685

Recent Advances and Perspectives on Expanding the Chemical Diversity of Lasso Peptides

Mengjiao Wang, Christopher D. Fage, Yile He, Jinhui Mi, Yang Yang, Fei Li, Xiaoping An, Huahao Fan, Lihua Song, Shaozhou Zhu and Yigang Tong

Front. Bioeng. Biotechnol., 2021, 9
DOI: 10.3389/fbioe.2021.741364

Triculamin: An Unusual Lasso Peptide with Potent Antimycobacterial Activity

Frederikke D. Andersen, Katja D. Pedersen, Dennis Wilkens Juhl, Tobias Mygind, Paul Chopin, Esben B. Svenningsen, Thomas B. Poulsen, Marie Braad Lund, Andreas Schramm, Charlotte H. Gotfredsen and Thomas Tørring

J. Nat. Prod., 2022, 85, 1514
DOI: 10.1021/acs.jnatprod.2c00065

Bacillus haimaensis sp. nov.: a novel cold seep-adapted bacterium with unique biosynthetic potential

Yuanyuan Wang, Luyi Yang, Wenbo Wu, Zhengqi Feng, Jian He, Changjun Guo, Jianguo He and John R. Spear

Appl Environ Microbiol, 2025, 91
DOI: 10.1128/aem.02456-24

Factors Governing the Thermal Stability of Lasso Peptides

Julian D. Hegemann

ChemBioChem, 2020, 21, 7
DOI: 10.1002/cbic.201900364

Enzymatic Reconstitution and Biosynthetic Investigation of the Lasso Peptide Fusilassin

Adam J. DiCaprio, Arash Firouzbakht, Graham A. Hudson and Douglas A. Mitchell

J. Am. Chem. Soc., 2019, 141, 290
DOI: 10.1021/jacs.8b09928

Generation of Lasso Peptide-Based ClpP Binders

Imran T. Malik, Julian D. Hegemann and Heike Brötz-Oesterhelt