Issue 39, 2013
From the journal:

Chemical Communications

N-Propargyloxycarbamate monosaccharides as metabolic chemical reporters of carbohydrate salvage pathways and protein glycosylation†‡

Leslie A. Bateman,a   Balyn W. Zaro,a   Kelly N. Chuha  and  Matthew R. Pratt*a  

* Corresponding authors

a Departments of Chemistry and Molecular and Computational Biology, University of Southern California, Los Angeles, USA
E-mail: matthew.pratt@usc.edu
Fax: +1 213 740 0930
Tel: +1 213 740 3014

Abstract

Metabolic chemical reporters of glycosylation allow for the visualization and identification of a variety of glycoconjugates by taking advantage of the promiscuity of carbohydrate metabolism. Here we describe the synthesis and characterization of metabolic chemical reporters bearing an N-propargyloxycarbamate (Poc) group that creates discrimination between glycosylation pathways.

Graphical abstract: N-Propargyloxycarbamate monosaccharides as metabolic chemical reporters of carbohydrate salvage pathways and protein glycosylation

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Article information

DOI
https://doi.org/10.1039/C2CC37963E
Article type
Communication
Submitted
02 Nov 2012
Accepted
03 Dec 2012
First published
03 Dec 2012

Chem. Commun., 2013,49, 4328-4330

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N-Propargyloxycarbamate monosaccharides as metabolic chemical reporters of carbohydrate salvage pathways and protein glycosylation

L. A. Bateman, B. W. Zaro, K. N. Chuh and M. R. Pratt, Chem. Commun., 2013, 49, 4328 DOI: 10.1039/C2CC37963E

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