Issue 85, 2022

Protein phosphatase 1 regulates phosphorylation of gasdermin D and pyroptosis

Abstract

We report that phosphorylation of gasdermin D (GSDMD)-NT, cleaved by inflammatory caspases, could inhibit pyroptosis. Phosphatase 1 (PP1) is responsible for the regulation of GSDMD phosphorylation and the capacity of GSDMD to induce cell death. Our findings reveal a critical regulatory mechanism as it provides insight into pyroptosis processes.

Graphical abstract: Protein phosphatase 1 regulates phosphorylation of gasdermin D and pyroptosis

Supplementary files

Article information

Article type
Communication
Submitted
28 јун. 2022
Accepted
29 септ. 2022
First published
30 септ. 2022

Chem. Commun., 2022,58, 11965-11968

Protein phosphatase 1 regulates phosphorylation of gasdermin D and pyroptosis

Y. Li, D. Pu, J. Huang, Y. Zhang and H. Yin, Chem. Commun., 2022, 58, 11965 DOI: 10.1039/D2CC03590A

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