Issue 8, 2020

Newly developed strategies for improving sonodynamic therapy

Abstract

Sonodynamic therapy (SDT) is a new therapeutic method, which can kill malignant tumors by using sonosensitizers and low intensity ultrasound (US) simultaneously. Compared with photo-triggered therapy, SDT exhibits lots of benefits and merits, including high accuracy, deeper tissue penetration, good patient compliance, and fewer side effects. US can penetrate the deep tissues and focus on the tumor areas, thereby activating sonosensitizers, which offers the possibility of non-invasively eradicating solid tumors in a targeted manner. However, the hypoxic tumor microenvironment (TME) and the low quantum yield of sonosensitizers limit the treatment efficiency of SDT. Therefore, it is crucial to improve the sonodynamic effect. In this minireview, we briefly introduce the possible mechanisms of SDT, including the production of reactive oxygen species (ROS), cavitation effect, and hyperthermia destruction. Then we summarize various newly developed strategies to improve the efficacy of SDT through the use of sonosensitizers based on the mechanisms of SDT, providing a theoretical basis for the development of SDT in the future. The strategies to improve the therapeutic efficiency of SDT mainly include: (1) improvement of hypoxia; (2) enhancement of the cavitation effect; (3) consumption of reducing substances (e.g., glutathione, GSH); (4) combination with hypoxia-activated chemotherapeutic drugs; and (5) combination with immunotherapy. In addition, we also focus on the potential strategies of combining SDT with other therapies, and discuss the challenges and limitations of SDT in future clinical applications.

Graphical abstract: Newly developed strategies for improving sonodynamic therapy

Article information

Article type
Minireview
Submitted
14 апр. 2020
Accepted
15 јун. 2020
First published
15 јун. 2020

Mater. Horiz., 2020,7, 2028-2046

Newly developed strategies for improving sonodynamic therapy

X. Wang, X. Zhong, F. Gong, Y. Chao and L. Cheng, Mater. Horiz., 2020, 7, 2028 DOI: 10.1039/D0MH00613K

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements