Issue 84, 2017

Controlling G-quadruplex formation via lipid modification of oligonucleotide sequences

Abstract

G-quadruplexes (G4) represent attractive supramolecular scaffolds. In this communication, we show that the lipid modification of a G4 prone oligonucleotide sequence drastically increases the probability of forming tetramolecular parallel G4s with unprecedented conformational control over other unspecific oligomers or folds.

Graphical abstract: Controlling G-quadruplex formation via lipid modification of oligonucleotide sequences

Supplementary files

Article information

Article type
Communication
Submitted
29 јул. 2017
Accepted
29 септ. 2017
First published
29 септ. 2017

Chem. Commun., 2017,53, 11560-11563

Controlling G-quadruplex formation via lipid modification of oligonucleotide sequences

B. Vialet, A. Gissot, R. Delzor and P. Barthélémy, Chem. Commun., 2017, 53, 11560 DOI: 10.1039/C7CC05693A

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