Ru(II)-Catalysed, Inherent-Directing Group Enabled Site-selective C-H Vinyl trifluoromethylation of Isoquinolones and Benzamides

Abstract

Herein, we unveil Ru(II)-catalysed an efficient and site-selective route for synthesising vinyltrifluoromethylated arenes by utilising amide carbonyl as an inherent directing group. 2-bromo-3,3,3-trifluoropropene has been utilised as a sustainable surrogate of vinyltrifluoromethylation to provide diversely decorated isoquinolones and benzamides. Mechanistic studies have been performed to articulate the plausible mechanism. A vast array of substrates is amenable to this transformation, and post-synthetic modification of products features the importance of the developed approach.