Visible-light-induced energy-transfer-mediated hydroacylation of alkenes with alcohol-derived oximes

Abstract

Herein, we report a visible light-driven hydroacylation strategy for the efficient synthesis of 1,4-ketoesters from alkenes and alcohol-derived oximes under mild conditions. The reaction proceeds via an energy transfer (EnT)-mediated pathway, wherein homolytic N–O bond cleavage generates alkoxy radicals that serve as key intermediates for subsequent radical addition to alkenes. This method features a broad substrate scope and high functional group tolerance, and delivers 1,4-ketoesters in good yields.