BrainBike peptidomimetic enables efficient transport of proteins across brain endothelium†
Maria C.
Lucana, 
a
Roberta
Lucchi,
a
Fabien
Gosselet,
b
Cristina
Díaz-Perlas
*a
and
Benjamí
Oller-Salvia
*a
a
Roberta
Lucchi,
a
Fabien
Gosselet,
b
Cristina
Díaz-Perlas
*a
and
Benjamí
Oller-Salvia
*a
Abstract
Protein therapeutics cannot reach the brain in sufficient amounts because of their low permeability across the blood–brain barrier. Here we report a new family of bicyclic peptide shuttles, BrainBikes, capable of increasing transport of proteins, including antibody derivatives, in a human cell-based model of the blood–brain barrier.
- This article is part of the themed collections: RSC Chemical Biology – Editors Choice Collection 2023 and 2023 RSC Chemical Biology Emerging Investigators
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