Issue 22, 2022

Benzo[4,5]imidazo[1,2-a]pyridines and benzo[4,5]imidazo[1,2-a]pyrimidines: recent advancements in synthesis of two diversely important heterocyclic motifs and their derivatives

Abstract

Nitrogen heterocycles are some of the most important compounds that are found in nature or synthesized otherwise. These heterocyclic rings are found almost invariably in living systems ranging from the tiniest prokaryotes to the largest eukaryotes. Various enzymes, proteins, and most importantly, DNA, consist of nitrogen heterocycles. Benzo[4,5]imidazo[1,2-a]pyridines and benzo[4,5]imidazo[1,2-a]pyrimidines also fall in this category and are quite important due to their ability to bind with various living systems. Many drugs contain these moieties at their cores. The potential of various derivatives of these skeletons to be used not only as drugs, but also as organoelectronic materials; fluorescent materials, etc. cannot be ignored. This review focuses on the synthesis of various derivatives of these scaffolds by a wide range of methodologies for the last decade. We have also demonstrated detailed synthetic pathways of each methodology and also highlighted variation of yields in different points of view.

Graphical abstract: Benzo[4,5]imidazo[1,2-a]pyridines and benzo[4,5]imidazo[1,2-a]pyrimidines: recent advancements in synthesis of two diversely important heterocyclic motifs and their derivatives

Article information

Article type
Perspective
Submitted
31 јан. 2022
Accepted
12 мај 2022
First published
13 мај 2022

New J. Chem., 2022,46, 10504-10534

Benzo[4,5]imidazo[1,2-a]pyridines and benzo[4,5]imidazo[1,2-a]pyrimidines: recent advancements in synthesis of two diversely important heterocyclic motifs and their derivatives

S. Debnath, S. Parveen, P. Pradhan, I. Das and T. Das, New J. Chem., 2022, 46, 10504 DOI: 10.1039/D2NJ00546H

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements