3D printing of artificial skin patches with bioactive and optically active polymer materials for anti-infection and augmenting wound repair

Hao Zhao; Jingwen Xu; Haitao Yuan; Endong Zhang; Nan Dai; Zhiqiang Gao; Yiming Huang; Fengting Lv; Libing Liu; Qi Gu; Shu Wang

doi:10.1039/D1MH00508A

3D printing of artificial skin patches with bioactive and optically active polymer materials for anti-infection and augmenting wound repair†

Hao Zhao,

‡^ad Jingwen Xu,‡^bc Haitao Yuan,^a Endong Zhang,^ad Nan Dai,

^ad Zhiqiang Gao,^ad Yiming Huang,

^a Fengting Lv,

^a Libing Liu,

^ad Qi Gu

*^bc and Shu Wang

*^ad

Author affiliations

* Corresponding authors

^a Beijing National Laboratory for Molecular Sciences, Key Laboratory of Organic Solids, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100190, P. R. China
E-mail: wangshu@iccas.ac.cn

^b State Key Laboratory of Membrane Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing 100101, P. R. China
E-mail: qgu@ioz.ac.cn

^c Institute for Stem Cell and Regeneration, Chinese Academy of Sciences, Beijing 100101, China

^d College of Chemistry, University of Chinese Academy of Sciences, Beijing 100049, P. R. China

Abstract

A printable ink composed of a photoactive cationic conjugated poly(phenylene vinylene) derivative (PPV) and gelatin/alginate/hyaluronic acid is developed for 3D printing artificial skin patches. This patch shows excellent photodynamic therapy-based anti-infection superiority and outstanding bioactivity to facilitate wound repair. This study contributes to design new conjugated polymer inks for manufacturing functional skin patches.

This article is part of the themed collections: Horizons Community Board Collection: Antimicrobial materials and surfaces and Special issue in honour of Seth Marder

Materials Horizons

3D printing of artificial skin patches with bioactive and optically active polymer materials for anti-infection and augmenting wound repair†

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3D printing of artificial skin patches with bioactive and optically active polymer materials for anti-infection and augmenting wound repair

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