Application of blocking and immobilization of electrospun fiber in the biomedical field

Abstract

The fiber obtained by electrospinning technology is a kind of biomaterial with excellent properties, which not only has a unique micro–nanostructure that gives it a large specific surface area and porosity, but also has satisfactory biocompatibility and degradability (if the spinning material used is a degradable polymer). These biomaterials provide a suitable place for cell attachment and proliferation, and can also achieve immobilization. On the other hand, its large porosity and three-dimensional spatial structure show unique blocking properties in drug delivery applications in order to achieve the purpose of slow release or even controlled release. The immobilization effect or blocking effect of these materials is mainly reflected in the hollow or core–shell structure. The purpose of this paper is to understand the application of the electrospun fiber based on biodegradable polymers (aliphatic polyesters) in the biomedical field, especially the immobilization or blocking effect of the electrospun fiber membrane on cells, drugs or enzymes. This paper focuses on the performance of these materials in tissue engineering, wound dressing, drug delivery system, and enzyme immobilization technology. Finally, based on the existing research basis of the electrospun fiber in the biomedical field, a potential research direction in the future is put forward, and few suggestions are also given for the technical problems that urgently need to be solved.