Issue 16, 2018

A facile synthesis of diverse 5-arylated triazoles via a Cu-catalyzed oxidative interrupted click reaction with arylboronic acids in air

Abstract

We herein disclose a Cu-catalyzed synthesis of 5-arylsubstituted 1,2,3-triazoles via an oxidative interrupted click reaction, using air as the sole terminal oxidant. The current protocol provides a novel method for the one-step construction of fully substituted triazoles in good yields under mild conditions, in which arylboronic acids are employed as aromatic sources to interrupt the cuprate–triazole intermediate for the first time.

Graphical abstract: A facile synthesis of diverse 5-arylated triazoles via a Cu-catalyzed oxidative interrupted click reaction with arylboronic acids in air

Supplementary files

Article information

Article type
Research Article
Submitted
13 јун. 2018
Accepted
03 јул. 2018
First published
04 јул. 2018

Org. Chem. Front., 2018,5, 2463-2467

A facile synthesis of diverse 5-arylated triazoles via a Cu-catalyzed oxidative interrupted click reaction with arylboronic acids in air

X. Yu, J. Xu, Y. Zhou and Q. Song, Org. Chem. Front., 2018, 5, 2463 DOI: 10.1039/C8QO00590G

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