Issue 21, 2017

A survey of the different roles of polyoxometalates in their interaction with amino acids, peptides and proteins

Abstract

One of the most attractive areas in inorganic chemistry is the synthesis of polyoxometalates (POMs) exhibiting new properties and applications. Since the impact of POMs in biochemistry and related fields of research has increased in the last few years, there has been a special interest in this topic. Significant progress in biological applications has been made where the interaction of POMs with amino acids, peptides and proteins is relevant. Versatile POMs play a series of different roles in the interaction with these biomolecules as described in this review. Various types of interactions are established, depending on the POM shape and charge, the amino acid side chain, peptide sequence or protein structure. Experimental conditions such as temperature, acidity, solvent, etc. are also important factors that influence the binding/reactivity of POM with biomolecules, as described herein. This understanding allows the adequate design of the POM-biomolecule couple for tailoring and controlling mechanisms of action such as catalysis, inhibition, and aggregation, or the crystallising agent.

Graphical abstract: A survey of the different roles of polyoxometalates in their interaction with amino acids, peptides and proteins

Article information

Article type
Perspective
Submitted
11 мар. 2017
Accepted
02 мај 2017
First published
02 мај 2017

Dalton Trans., 2017,46, 6812-6829

A survey of the different roles of polyoxometalates in their interaction with amino acids, peptides and proteins

M. Arefian, M. Mirzaei, H. Eshtiagh-Hosseini and A. Frontera, Dalton Trans., 2017, 46, 6812 DOI: 10.1039/C7DT00894E

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements