Issue 45, 2015

Chemo-, regio-, and stereo-selective perfluoroalkylations by a Grignard complex with zirconocene

Abstract

The synthesis of highly reactive perfluoroalkyl Grignard reagents with early transition metal zirconocene complexes and their new types of highly chemo-, regio-, and stereo-selective perfluoroalkylation reactions are reported with epoxides in particular. The zirconocene complex is advantageous in activating the perfluoroalkyl Grignard species. The zirconocene·Grignard complexes were clarified by DOSY. Both 1H and 19F DOSY analyses show that the addition of MAO and dioxane to the mixture of RFMgCl and Cp2ZrCl2 connects Cp2Zr and RFMg to generate the zirconocene/perfluoroalkyl-Grignard/dioxane complex.

Graphical abstract: Chemo-, regio-, and stereo-selective perfluoroalkylations by a Grignard complex with zirconocene

  • This article is part of the themed collection: Fluorine

Supplementary files

Article information

Article type
Communication
Submitted
07 авг. 2015
Accepted
28 септ. 2015
First published
06 окт. 2015

Dalton Trans., 2015,44, 19464-19468

Chemo-, regio-, and stereo-selective perfluoroalkylations by a Grignard complex with zirconocene

M. Fujiu, K. Negishi, J. Guang, P. G. Williard, S. Kuroki and K. Mikami, Dalton Trans., 2015, 44, 19464 DOI: 10.1039/C5DT03039K

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements