Issue 42, 2013
From the journal:

Chemical Communications

A foldamer approach to targeting membrane bound helical states of islet amyloid polypeptide†

Sunil Kumara  and  Andrew D. Miranker*a  

* Corresponding authors

a Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, USA
E-mail: Andrew.Miranker@yale.edu
Fax: +1 (203) 432-5175
Tel: +1 (203) 432-8954

Abstract

A small molecule, protein mimetic based approach is shown to specifically inhibit lipid catalysed self-assembly of islet amyloid polypeptide (IAPP). The lipid-bound oligomerization of this peptide is implicated in cellular dysfunction of insulin secreting β-cells in type II diabetes.

Graphical abstract: A foldamer approach to targeting membrane bound helical states of islet amyloid polypeptide

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Article information

DOI
https://doi.org/10.1039/C3CC41452C
Article type
Communication
Submitted
25 фев. 2013
Accepted
03 апр. 2013
First published
04 апр. 2013

Chem. Commun., 2013,49, 4749-4751

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A foldamer approach to targeting membrane bound helical states of islet amyloid polypeptide

S. Kumar and A. D. Miranker, Chem. Commun., 2013, 49, 4749 DOI: 10.1039/C3CC41452C

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