Issue 17, 2011
From the journal:

Chemical Communications

Reactive oxygen species in photochemistry of the red fluorescent protein “Killer Red”†

Russell B. Vegh,ab   Kyril M. Solntsev,*a   Marina K. Kuimova,c   Soohee Cho,ab   Yue Liang,bd   Bernard L. W. Loo,bd   Laren M. Tolberta  and  Andreas S. Bommarius*abd  

* Corresponding authors

a School of Chemistry and Biochemistry, Georgia Institute of Technology, Atlanta, Georgia 30332-0400, USA
E-mail: solntsev@gatech.edu

b Parker H. Petit Institute of Bioengineering and Biosciences, Georgia Institute of Technology, Atlanta, Georgia 30332-0363, USA

c Chemistry Department, Imperial College London, Exhibition Road, South Kensington, London, UK

d School of Chemical and Biomolecular Engineering, Georgia Institute of Technology, Atlanta, Georgia 30332-0100, USA
E-mail: andreas.bommarius@chbe.gatech.edu
Fax: +1 404 8947452
Tel: +1 404 3853117

Abstract

The fluorescent protein aptly named “Killer Red” (KRed) is capable of killing transfected cells and inactivating fused proteins upon exposure to visible light in the presence of oxygen. We have investigated the source of the bioactive species through a variety of photophysical and photochemical techniques. Our results indicate a Type I (electron transfer mediated) photosensitizing mechanism.

Graphical abstract: Reactive oxygen species in photochemistry of the red fluorescent protein “Killer Red”

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Article information

DOI
https://doi.org/10.1039/C0CC05713D
Article type
Communication
Submitted
21 дек. 2010
Accepted
09 фев. 2011
First published
28 фев. 2011

Chem. Commun., 2011,47, 4887-4889

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Reactive oxygen species in photochemistry of the red fluorescent protein “Killer Red”

R. B. Vegh, K. M. Solntsev, M. K. Kuimova, S. Cho, Y. Liang, B. L. W. Loo, L. M. Tolbert and A. S. Bommarius, Chem. Commun., 2011, 47, 4887 DOI: 10.1039/C0CC05713D

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