Issue 12, 2016

2D wax-printed paper substrates with extended solvent supply capabilities allow enhanced ion signal in paper spray ionization

Abstract

Paper-based microfluidic channels were created from solid wax printing, and the resultant 2D wax-printed paper substrates were used for paper spray (PS) mass spectrometry (MS) analysis of small organic compounds. Controlling fluid flow at the tip of the wax-printed paper triangles enabled the use of lower spray voltages (0.5–1 kV) and extended signal lifetime (10 minutes) in PS-MS. High sensitivity (sub ng mL−1 levels) and quantitation precision (<10% RSD) have been achieved in the analysis of illicit drugs in 4 μL of raw urine (fresh and dry), as well as corrosion inhibitors and pesticides in water samples. The reported study encourages the future development of disposable 3D microfluidic paper-based analytical devices, which function with simple operation but capable of on-chip analyte detection by MS; such a device can replace the traditional complex laboratory procedures for MS analysis to enable on-site in situ sampling with portable mass spectrometers.

Graphical abstract: 2D wax-printed paper substrates with extended solvent supply capabilities allow enhanced ion signal in paper spray ionization

Supplementary files

Article information

Article type
Paper
Submitted
23 јан. 2016
Accepted
15 апр. 2016
First published
18 апр. 2016

Analyst, 2016,141, 3866-3873

2D wax-printed paper substrates with extended solvent supply capabilities allow enhanced ion signal in paper spray ionization

D. E. Damon, Y. S. Maher, M. Yin, F. P. M. Jjunju, I. S. Young, S. Taylor, S. Maher and A. K. Badu-Tawiah, Analyst, 2016, 141, 3866 DOI: 10.1039/C6AN00168H

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements