Issue 10, 2014

The role of reversibility in the enantioselective conjugate addition of α,α-disubstituted aldehydes to nitro-olefins catalyzed by primary amine thioureas

Abstract

Kinetic and spectroscopic studies probing the conjugate addition of 2-phenylpropanal to nitro-olefins catalyzed by two different primary amine thiourea catalysts reveal the nature of the catalyst resting state and demonstrate that reversibility of the reaction is implicated in cases of low enantio- and diastereoselectivity.

Graphical abstract: The role of reversibility in the enantioselective conjugate addition of α,α-disubstituted aldehydes to nitro-olefins catalyzed by primary amine thioureas

Supplementary files

Article information

Article type
Paper
Submitted
19 мај 2014
Accepted
21 јун. 2014
First published
23 јун. 2014

Catal. Sci. Technol., 2014,4, 3505-3509

Author version available

The role of reversibility in the enantioselective conjugate addition of α,α-disubstituted aldehydes to nitro-olefins catalyzed by primary amine thioureas

Y. Ji and D. G. Blackmond, Catal. Sci. Technol., 2014, 4, 3505 DOI: 10.1039/C4CY00648H

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