Issue 38, 2014

Site-specific cross-linking of collagen peptides by lysyl advanced glycation endproducts

Abstract

Cross-linking of proteins by advanced glycation endproducts (AGEs) causes a host of pathological conditions but their exact roles are unknown. Cross-linking lysyl AGEs were synthesized and incorporated into two types of collagen peptides. The utility of these cross-linked peptides for biochemical investigations was demonstrated by proteolysis studies and circular dichroism.

Graphical abstract: Site-specific cross-linking of collagen peptides by lysyl advanced glycation endproducts

Supplementary files

Article information

Article type
Communication
Submitted
17 мар. 2014
Accepted
27 мар. 2014
First published
31 мар. 2014

Chem. Commun., 2014,50, 4944-4946

Author version available

Site-specific cross-linking of collagen peptides by lysyl advanced glycation endproducts

M. Kamalov, P. W. R. Harris, G. J. S. Cooper and M. A. Brimble, Chem. Commun., 2014, 50, 4944 DOI: 10.1039/C4CC02003K

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