Cholesterol-containing ionizable lipids for safe and efficient mRNA delivery via lipid nanoparticles

Liang Xie, Haiyang Li, Jiangsheng Xu, Fang Zeng and Shuizhu Wu

New J. Chem., 2026, 50, 8608
DOI: 10.1039/D6NJ00164E

Oxabispidine-derived ionizable lipids for effective mRNA delivery to the lungs using lipid nanoparticles

Charles H. Chen, Eric L. Dane, Steven Oag, Elin Sand, Patrik Andersson, Annette Bak and Liping Zhou

Org. Biomol. Chem., 2026, 24, 481
DOI: 10.1039/D5OB01888A

Functional Reclassification of Lipid-Based Drug Delivery Systems and Advances in Formulation Strategies and Manufacturing Challenges

Pranal Chhetri

AAPS PharmSciTech, 2026, 27
DOI: 10.1208/s12249-026-03415-5

Deciphering the biological fate of mRNA-LNP-based biologics: A perspective from tissue to intracellular distribution

Xin Xu, Lili Cui, Yong Zhang and Jingkai Gu

Acta Pharmaceutica Sinica B, 2026, 16, 1943
DOI: 10.1016/j.apsb.2025.11.023

Lyophilized monoclonal antibody (mAb) encoded mRNA—lipid nanoparticles (LNPs) lead to stable in vivo expression of mAb after room temperature storage

Zimeng Wang, Bei Cheng, Christine Tkaczyk, Michael Newton, Shuolin Cui, Bohdan Andreiuk, Sanjib Saha, Sabrina Khan, Charles Chen, Bin Yang, Adam Gamson, Sarah Siddiqui, George Thom, Antonio DiGiandomenico and Liping Zhou

AAPS Open, 2026, 12
DOI: 10.1186/s41120-026-00147-5

Synergistic Co-Delivery of siFGF2 and Doxorubicin via QTPlus Nanoparticles for Enhanced Breast Cancer Therapy

Xiaohan Xia, Zhongkun Zhang, Jingjing Zhang, Kaixin Feng, Yufei Wang, Robert J. Lee, Siyu Yao and Min Wu

Pharmaceutics, 2026, 18, 589
DOI: 10.3390/pharmaceutics18050589

PRELIVE: A Framework for Predicting Lipid Nanoparticles In Vivo Efficacy and Reducing Reliance on Animal Testing

Belal I. Hanafy, Chuan‐En Lu, Kai Liu and Audrey Gallud

Adv Funct Materials, 2026, 36
DOI: 10.1002/adfm.202525076