cGAS–STING pathway modulation: A new hope for neural regeneration

Jinghan Zhang, Mouyuan Sun, Yaxian Luo, Mikko Petteri Räisänen, Lianjie Peng, Luying Qin, Mengfei Yu and Haifei Shi

Neural Regeneration Research, 2026, 21, 4028
DOI: 10.4103/NRR.NRR-D-24-01516

Nucleic Acid Diversity in cGAS-STING Pathway Activation and Immune Dysregulation

Jingwei Guo, Mingjun Lu, Chenyang Wang, Dongchang Wang and Teng Ma

Biomedicines, 2025, 13, 2158
DOI: 10.3390/biomedicines13092158

cGAS–STING Signaling in Central Nervous System Diseases: Neuroinflammatory Mechanisms and Immune Regulation

Wujun Wang, Lijuan Wang, Xintong Zhong, Dong Li, Lingyun Zhang and Jun Hu

Cell Biochemistry & Function, 2025, 43
DOI: 10.1002/cbf.70146

Dynamic Bionic Organelle‐Migrating Fluorescence Probe for Mitochondrial and Nuclear Parallel G4 DNA Imaging and Enhanced Cancer Therapy

Yuanyuan Li, Tian Wu, Qiuya Wang, Ting Chen, Yibing Wang and Yanmei Zhou

Adv Funct Materials, 2026, 36
DOI: 10.1002/adfm.202519674

Targeting DHODH promoter G-quadruplex to induce ferroptosis in melanoma cells

Wenhe Zhang, Qi Xu and Yutong Sui

Biochemical and Biophysical Research Communications, 2026, 795, 153117
DOI: 10.1016/j.bbrc.2025.153117

The G-quadruplex ligand CX-5461: an innovative candidate for disease treatment

Hong-Xia Li, Yi-Meng He, Jing Fei, Man Guo, Chen Zeng, Pi-Jun Yan, Yong Xu, Gang Qin and Fang-Yuan Teng

J Transl Med, 2025, 23
DOI: 10.1186/s12967-025-06473-8

Lock-equipped six-helix DNA bundle-mediated siSTING delivery ameliorates Alzheimer’s disease via cGAS-STING inhibition

Manqing Zhang, Yufei Lan, Qu Yue, Jinjun He, Lei Li, Huan Zhang, Yaoyuan Dong, Yuankai Wang, Jiankun Lu, Zhijie Lu, Feiyunduo Hao, Sui Chen, Yixiao Jiang, Chao Zhang, Yan Zhao and Hongbo Guo

J Nanobiotechnol, 2026, 24
DOI: 10.1186/s12951-026-04173-z

Smart drug in cancer treatment: Design, synthesis and biophysical characterization of uracil-containing cyclic hypervalent iodine (Uracil-BX) reagent with G-quadruplex DNA structures

Sukanya Das, Sagar Bag, Md. Abbasuddin Sk, Raj K. Nandi and Sudipta Bhowmik

Bioorganic Chemistry, 2025, 165, 109021
DOI: 10.1016/j.bioorg.2025.109021

The cGAS-STING pathway in senescence and aging-related diseases: mechanisms and therapeutic opportunities

Shiqing Tan, Eugenie Nepovimova, Marian Valko, Klaudia Jomova, Qinghua Wu and Kamil Kuca

Cell Commun Signal, 2026, 24
DOI: 10.1186/s12964-026-02855-7

The Role and Therapeutic Potential of the cGAS‐STING Signaling Pathway in Alzheimer's Disease

Xue Li, Wei Gao, Qiuyan Ye and Honglin Li

Brain and Behavior, 2025, 15
DOI: 10.1002/brb3.71130

Precisely Targeting TGF‐β1 Promoter G‐Quadruplex for Expediting Maturation of Tumor Dendritic Cells to Overcome Immune Evasion

Chenglong Ma, Yue Sun, Heying Yuan, Junlin Ya, Chunyu Wang, Chuanqi Zhao and Xiaogang Qu

Small Methods, 2026, 10
DOI: 10.1002/smtd.202500650

The STING Signaling: A Novel Target for Central Nervous System Diseases

Min Song, Jianxun Ren, Zhipeng Zhu, Zhaohui Yi, Chengyun Wang, Lirong Liang, Jiahui Tian, Guofu Mao, Guohua Mao and Min Chen

Cell Mol Neurobiol, 2025, 45
DOI: 10.1007/s10571-025-01550-4

Senescent Microglia Mediate Neuroinflammation‐Induced Cognitive Dysfunction by Selective Elimination of Excitatory Synapses in the Hippocampal CA1

Kai Liu, Di Fan, Hai‐peng Wu, Xiao‐yi Hu, Qiu‐li He, Xin‐miao Wu, Cui‐na Shi, Jian‐jun Yang and Mu‐huo Ji

Aging Cell, 2025, 24
DOI: 10.1111/acel.70167