A comprehensive review and recent advances on isatin-based compounds as a versatile framework for anticancer therapeutics (2020–2025)

Muna A. Alshams, Mohamed S. Nafie, Heba F. Ashour and Asmaa S. A. Yassen

RSC Adv., 2025, 15, 32188
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Medicinal chemistry perspectives on anticancer drug design based on clinical applications (2015–2025)

Ahmed A. Al-Karmalawy, Mohamed E. Eissa, Nada A. Ashour, Tarek A. Yousef, Arwa Omar Al Khatib and Samia S. Hawas

RSC Adv., 2025, 15, 36441
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Pyrazole–triazole hybrids as kinase-triad inhibitors: a triple-target strategy for synergistic anticancer therapy

Mahmoud S. Elkotamy, Mohamed K. Elgohary, Mariam M. Fakhry, Mohamed E. Albakri, Abdelrahman A. Naglah, Abdulrahman A. Almehizia, Ahmed M. Naglah, Mohamed Fares, Haytham O. Tawfik, Wagdy M. Eldehna and Hatem A. Abdel-Aziz

RSC Med. Chem., 2026, 17, 2360
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Design, Synthesis, and Evaluation of Nitroquinoline Fused Thiosemicarbazones for Anti‐Cancer Activity on Human Cervical Cancer Cell Lines

Vandana Nandakumar, Sentamil Selvi Ramasamy, Kaviyarasu Adhigaman, Amsaveni Sundarasamy, Deepak Arumugam, Shankar Ramasamy, Raju Vivek and Suresh Thangaraj

ChemistrySelect, 2025, 10
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Designing Telomerase Inhibitors for Cancer Therapy: Mechanistic Insights, Medicinal Chemistry Strategies, Challenges, and Future Directions

Ahmed A. Al‐Karmalawy, Mohamed Ibrahim Attia, Marwa Sharaky, Arwa Omar Al Khatib, Tarek A. Yousef and Samia S. Hawas

Archiv der Pharmazie, 2026, 359
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Innovative Multitarget Organoselenium Hybrids With Apoptotic and Anti‐Inflammatory Properties Acting as JAK1/STAT3 Suppressors

Saad Shaaban, Aya Yaseen Mahmood Alabdali, Mai H. A. Mousa, Hussein Ba‐Ghazal, Yasair S. Al‐Faiyz, Ibrahim Elghamry, Hanan A. Althikrallah, Arwa Omar Al Khatib, Mohamed Alaasar and Ahmed A. Al‐Karmalawy

Drug Development Research, 2025, 86
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Triazole–Sulfonamide Hybrids as Carbonic Anhydrase Inhibitors: Emerging Chemistry and Bioactivity Insights From 2020 to 2025

Mohamed S. Nafie, Heba F. Ashour, Sherif Ahsraf Fahmy, Mohamed K. Diab, Mohamed Reda Aouad, Nadjet Rezki and Asmaa S. A. Yassen

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PTC‐Assisted Chemoselective S‐Alkylation of 5‐Mercapto‐1,3,4‐Oxadiazol Derivative: Multi‐Target Anticancer via EGFR, Telomerase, and Thymidylate Synthase Inhibition With Apoptosis Induction

Asmaa Zakaria, Ahmed A. Al‐Karmalawy, Samia S. Hawas, Ali Khalil Ali, Galal A. Elsayed, Arwa Omar Al Khatib and Eslam M. Abbass

Drug Development Research, 2026, 87
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Telomerase inhibitors - TMPyP4, BIBR 1532 and imetelstat - alter the adhesion potential of breast cancer MCF7 and MDA-MB-231 cells that leads to impaired ability to form spheroids

Przemysław Kopczyński, Aleksandra Romaniuk-Drapała, Kinga Rygiel, Jacek Kujawski and Błażej Rubiś

Cell Adhesion & Migration, 2025, 19
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Investigating the Telomerase Downregulatory Potential of Steroidal Drugs Following Pharmacophore‐Based Rational; Computational and In Vitro Assessments

Ahmed A. Al‐Karmalawy, Aya Yaseen Mahmood Alabdali, Tarek A. Yousef, Ayman Abo Elmaaty, Mashael A. Alghamdi, Arwa Omar Al Khatib, Amany Belal and Marwa Sharaky

Archiv der Pharmazie, 2026, 359
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Diversity and Multi-Target Potential of Pyrazole, Imidazole or Triazole Derivatives in Modern Anticancer Therapy

Martyna Mysłek, Anna Kaczmarek, Piotr Świątek and Żaneta Czyżnikowska

IJMS, 2026, 27, 4172
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Structure‐Based Virtual Screening to Discover Potential Triazole Hits as an Anticancer Agents Targeting Telomerase Enzyme

Saloni P. Jaiswal, Shravani U. Bhadke, Srikanth Jupudi, Vasundhara N. Sawant and Vishal P. Zambre

ChemistrySelect, 2025, 10
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Recent Advances in Benzimidazole–Triazole Hybrids for Single- and Multi-Target Protein Kinase Inhibition

Hamzeh M. Abu Al Rub and Ahmed G. Eissa

Pharmaceuticals, 2026, 19, 623
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Genetic algorithm-guided design of garlic-derived ligands targeting the TEN domain of telomerase reverse transcriptase with machine learning-based activity classification

Hassen Elmir, Abdelkader Ghazli, Larbi Boubchir and Abdelaziz Daoudi

Computer Methods in Biomechanics and Biomedical Engineering, 2026, 1
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Rational Design of Multifunctional 1,2,4-Triazole-3-thione Hybrids as Potential Modulators of EGFR Signaling and β-Tubulin in Hepatocellular Carcinoma

Marwa Abdel-Motaal, Marwa Sharaky, Samia S. Hawas, Fatmah Aljudan, Azizah Algreiby, Mohamed M. Hammouda, Arwa Omar Al Khatib and Ahmed A. Al-Karmalawy

Journal of Molecular Structure, 2026, 146852
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Exploring pyrimidine Schiff bases as promising dual CDK8 and DNA ligase IV inhibitors: synthesis, characterization, and computational study

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Journal of Molecular Liquids, 2026, 449, 129434
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Recent progress in the exploitation of anti-cancer small molecules targeting angiogenesis

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Journal of Enzyme Inhibition and Medicinal Chemistry, 2025, 40
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Multi‐Target Rational Design and Synthesis of Some 2‐Quinolinone Antitumor Candidates Downregulating the Expression of EGFR, VEGFR‐2, and Telomerase With Apoptotic Potential

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Drug Development Research, 2025, 86
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