Recent advances in centrifugal microfluidics for point-of-care testing

Huijuan Yuan, Zeyu Miao, Chao Wan, Jingjing Wang, Jinzhi Liu, Yiwei Li, Yujin Xiao, Peng Chen and Bi-Feng Liu

Lab Chip, 2025, 25, 1015
DOI: 10.1039/D4LC00779D

Microfluidics for cell therapy and manufacturing in oncology and regenerative medicine

Josie L. Duncan, Julio P. Arroyo and Rafael V. Davalos

Lab Chip, 2026, 26, 1566
DOI: 10.1039/D5LC00492F

A multi-valve centrifugal microfluidic for Mycoplasma pneumoniae detection

Guangyao Chen, Yu Lu, Hao Shen, Jing Zhang, Yizhu Liu, Liwei Xue and Liguo Chen

Lab Chip, 2025, 25, 6248
DOI: 10.1039/D5LC00667H

Rapid on-chip nucleic acid extraction for point-of-care salivary diagnostics

Siril Arockiam, Vi T. Nguyen, Mark Knappenberger, Clifford Anderson, Michael Hansen, Vel Murugan, Jennifer Blain Christen and Karen S. Anderson

Anal. Methods, 2025, 17, 4321
DOI: 10.1039/D4AY02201G

Centrifugation-free sequential-flow microfluidic chip with a passive valve for nucleic acid extraction and photonic PCR verification

Jae Hwan Oh, Kyung Ho Kim, Sung Eun Seo, Kyoung G. Lee, Yu Kyung Kim, Hyung Do Kim, Yeong-Eun Yoo and Oh. Seok Kwon

Chemical Engineering Journal, 2026, 177841
DOI: 10.1016/j.cej.2026.177841

Construction of a two-dimensional magnetic solid phase extraction microfluidic chip/tandem mass spectrometry platform for the determination of cytarabine in plasma

Yangkun Sun, Yu Han, Linghao Zhao, Yuanzheng Xiang, Wenjing Xiong, Hongyang Zhang, Min Zhang, Fanghong Ning and Ping Hu

Microchemical Journal, 2024, 207, 112150
DOI: 10.1016/j.microc.2024.112150

A fully automatic and high-throughput centrifugal microsystem for rapid nucleic acid purification with a direct collection via detachable microtube interface

Thanh Hoai Nguyen, Hiep Van Nguyen, Vu Minh Phan and Tae Seok Seo

Sensors and Actuators B: Chemical, 2025, 437, 137748
DOI: 10.1016/j.snb.2025.137748

Smart microfluidics-powered home-based diagnostics for one-health: From technologies to applications

Xiaowen Ou, Qize Zhou, Mudong Wu, Zeyu Miao, Yufei Zhang, Zuyi Li, Ying Zhang, Yiwei Li, Peng Chen and Bi-Feng Liu

TrAC Trends in Analytical Chemistry, 2026, 196, 118633
DOI: 10.1016/j.trac.2025.118633

Research advances in centrifugal microfluidics and its applications

Zhichang Du, Junpeng Lin, Beichen Lin and Shaohui Yang

Microchemical Journal, 2025, 213, 113589
DOI: 10.1016/j.microc.2025.113589

Drip-Dry Strategy Assisted Blu-Ray Disc Biosensor for Fast Point of Care Testing

Yunhao Zhang, Wenjie Lv, Zixin Kang, Anxin Guo, Junming Li, Chenxi Dai, Mingyu Zhang, Siyu Gao, Shunji Li, Zeyu Miao, Sihan Chen, Xiaojun Feng, Yiwei Li, Peng Chen and Bi-Feng Liu

Anal. Chem., 2024
DOI: 10.1021/acs.analchem.4c02651

Magnet regulating valve reconstructed lab-on-a-disc POCT system

Siyuan Wang, Shuqi Shen, Shimo Kang, Zheng Yan, Shijia Wu, Na Liu and Aibo Wu

Biosensors and Bioelectronics, 2026, 294, 118185
DOI: 10.1016/j.bios.2025.118185

Research on real-time nucleic acid detection device based on microfluidic technology

Shuo Wu, Jianxin Cheng, Xiaohua Cao, Jingdong Bo, Shilun Feng and Chuanjin Cui

International Journal on Smart Sensing and Intelligent Systems, 2025, 18
DOI: 10.2478/ijssis-2025-0014

A Real-Time Centrifugal Microfluidic Chip with Dual-Valving Strategy for Multiplexed PCR Detection at Point-of-Care Testing

Yize Zhang, Youhong Zeng, Lingxuan Liu, Lei Wang, Hao Chen, Yatan Yuan, Yingying Ding, Guijun Miao, Lulu Zhang and Xianbo Qiu

Chemosensors, 2026, 14, 118
DOI: 10.3390/chemosensors14050118

Ergonomic handheld chip: An instrument-free RPA-CRISPR platform for rapid home self-testing

Jiashuo Li, Xin Wang, Shangang Wang, Kaiting Zhang, Ying Zhang, Tao Xu, Dongjuan Chen, Yiwei Li, Peng Chen and Bi-Feng Liu

Biosensors and Bioelectronics, 2026, 293, 118157
DOI: 10.1016/j.bios.2025.118157

Artificial intelligence enhanced microfluidic system for multiplexed point-of-care-testing of biological thiols

Siyu Gao, Jingjing Wang, Zeyu Miao, Xudong Zhao, Ying Zhang, Wei Du, Xiaojun Feng, Yiwei Li, Jinzhi Liu, Peng Chen and Bi-Feng Liu

Talanta, 2025, 287, 127619
DOI: 10.1016/j.talanta.2025.127619

The application of magnetic bead-based microfluidic technology in nucleic acid extraction

Yang Wang and Chuanjin Cui

Sensor Review, 2026, 46, 674
DOI: 10.1108/SR-10-2025-0802

Numerical and experimental analysis of a novel passive feedback valve for variable fluid volume metering in centrifugal microfluidic platforms

Amirhossein Saboorinia, Amirhosein Ghasemi and Abas Ramiar

Materials & Design, 2026, 262, 115474
DOI: 10.1016/j.matdes.2026.115474

Open-channel microfluidic device for TiO2NTs@Fe3O4NPs-assisted viral RNA extraction and amplification-free RNA fluorescence status evaluation

Nikola Matejkova, Denisa Smela, Martin Beranek, Jan Capek, Lucie Michalcova, Lenka Michalkova, Jakub Svoboda, Marek Skeren, Zuzana Svobodova, Hanna Sopha, Jan M. Macak, Lucie Korecka, Anna Pacinkova, Marketa Gancarcikova, Radka Bolehovska, Vladimir Koblizek and Zuzana Bilkova

Microchemical Journal, 2024, 206, 111554
DOI: 10.1016/j.microc.2024.111554

Portable, facile microfluidic platform using a low-cost vacuum pump for multiplex biomarker detection in human samples

Bo Liu, Jing Jin, Bin Ran, Chaozhan Chen, Jiaqian Li, Jinxiang Han and Yonggang Zhu

Sensors and Actuators B: Chemical, 2025, 426, 136994
DOI: 10.1016/j.snb.2024.136994

Determination of nucleosides in serum by two-dimensional magnetic solid-phase extraction microfluidic chip/liquid chromatography-mass spectrometry

Yongzhe Cheng, Yangkun Sun, Ningning Wang, Qiangqiang Jia, Linghao Zhao, Zeyu Wu, Yuerong Wang, Hongyang Zhang, Min Zhang and Ping Hu

Journal of Chromatography A, 2026, 1768, 466678
DOI: 10.1016/j.chroma.2026.466678

Active Microfluidic Mixing Using Photoacoustic Laser Streaming from Gold-Implanted Optical Fibers and Glass Beads

Tian Tong, Paththini Kuttige S. Nonis, Chengzhen Qin, Feng Lin, Elizabet Rosas, Di Chen, Wei-Kan Chu and Jiming Bao

J. Phys. Chem. C, 2025, 129, 6827
DOI: 10.1021/acs.jpcc.4c08786

Micropumps and microvalves for biomedical applications

Yun Zheng, Huanhuan Shi, Zhongjian Tan, Weizheng Xu, Rui Zhao, Zhengxian Dan, Zhiying Dai, Jiacong Liao and Hongwen Wu

TrAC Trends in Analytical Chemistry, 2025, 188, 118236
DOI: 10.1016/j.trac.2025.118236

Lab-on-a-Chip Devices for Nucleic Acid Analysis in Food Safety

Inae Lee and Hae-Yeong Kim

Micromachines, 2024, 15, 1524
DOI: 10.3390/mi15121524