Crocin extends lifespan by mitigating oxidative stress and regulating lipid metabolism through the DAF-16/FOXO pathway

Ai-Pei Li, Dan Li, Xin Tan, Rui Xu, Lin-Xi Mao, Juan-Juan Kang, Sheng-Hong Li and Yan Liu

Food Funct., 2025, 16, 3369
DOI: 10.1039/D5FO01157D

A comprehensive approach, based on the use of Caenorhabditis elegans, mouse, and human models, elucidates the impact of Lactiplantibacillus plantarum TWK10 on exercise performance and longevity

Jian-Fu Liao, Chia-Chia Lee, Mon-Chien Lee, Han-Yin Hsu, Ming-Fu Wang, Chi-Chang Huang, San-Land Young, Koichi Watanabe and Jin-Seng Lin

Current Research in Food Science, 2025, 10, 101015
DOI: 10.1016/j.crfs.2025.101015

C. elegans as a powerful model for neurotoxicity assessment

Daniel José Barbosa, Inês C. Santos, Tatiana Moyisyeyenko, Cristina Mendes and Ana Filipa Sobral

NeuroToxicology, 2025, 110, 85
DOI: 10.1016/j.neuro.2025.07.009

Effects of lutein, phytoene and carotenoid-rich microalgal extracts on the epidermis of Caenorhabditis elegans

Ángeles Morón-Ortiz, Mar Ferrando-Marco, Antonio León-Vaz, Rosa León, Paula Mapelli-Brahm, Michalis Barkoulas and Meléndez Martínez, Antonio Jesús

Food Chemistry, 2025, 497, 147022
DOI: 10.1016/j.foodchem.2025.147022

Exploring the anti-aging potential of natural products and plant extracts in budding yeast Saccharomyces cerevisiae: A review

Phaniendra Alugoju, Chella Perumal Palanisamy, Naga Venkata Anusha Anthikapalli, Selvaraj Jayaraman, Anchalee Prasanskulab, Siriporn Chuchawankul, Madhu Dyavaiah and Tewin Tencomnao

F1000Res, 2024, 12, 1265
DOI: 10.12688/f1000research.141669.2

Application of 3Rs in Caenorhabditis elegans Research for the Identification of Health-Promoting Natural Products

Martina Redl, Anusha Shayegan and Judith M. Rollinger

Planta Med, 2024, 90, 576
DOI: 10.1055/a-2254-0131

Caenorhabditis elegans as in vivo model for the screening of natural plants-derived novel anti-aging compounds: a short introduction

Samah H. O. Zarroug

Journal of Asian Natural Products Research, 2025, 27, 577
DOI: 10.1080/10286020.2024.2414189

Comparative Phytochemical Analysis of Gastrodiae Rhizoma Peel and Core and Their Lifespan-Extending Potential in Caenorhabditis elegans

Baoshan Li, Ke Mo, Lipeng Zhou, Yanjun Wang, Yaping Li, Wei Zhang, Chenghao Zhu and Zhirong Sun

Molecules, 2025, 30, 3474
DOI: 10.3390/molecules30173474

Short anti-aging peptides from edible microalgae using a multi-targets virtual screening strategy combined with Caenorhabditis elegans model

Yan-yan Yuan, Xin Li, Ming-hui Han, Xue An, Yong-Qiang Lin and Hong-Bing Liu

Food Research International, 2026, 235, 119202
DOI: 10.1016/j.foodres.2026.119202

Exploring the anti-aging potential of natural products and plant extracts in budding yeast Saccharomyces cerevisiae: A review

Phaniendra Alugoju, Chella Perumal Palanisamy, Naga Venkata Anusha Anthikapalli, Selvaraj Jayaraman, Anchalee Prasanskulab, Siriporn Chuchawankul, Madhu Dyavaiah and Tewin Tencomnao

F1000Res, 2023, 12, 1265
DOI: 10.12688/f1000research.141669.1

Dietary state and impact of DMSO on Caenorhabditis elegans aging: Insights from healthspan analysis

Yutaro Fukushima, Asuka Kagami, Hirotaka Sonoda, Kotomi Shimokawa, Mary Ann Suico, Hirofumi Kai and Tsuyoshi Shuto

Biochemical and Biophysical Research Communications, 2025, 742, 151156
DOI: 10.1016/j.bbrc.2024.151156

Antioxidant and anti-aging activities of Longan crude and purified polysaccharide (LP-A) in nematode Caenorhabditis elegans

Xiuhuan Guo, Quancheng Xin, Peng Wei, Yutong Hua, Yongchun Zhang, Zhaoyuqing Su, Gaimei She and Ruijuan Yuan

International Journal of Biological Macromolecules, 2024, 267, 131634
DOI: 10.1016/j.ijbiomac.2024.131634

Тритерпеноиды: природные соединения с высоким фармацевтическим потенциалом

М.С. Денисов

Perm Sci. Cent. J., 2025, 6
DOI: 10.7242/2658-705X/2024.4.1

Brief guide to assays for measuring health parameters using Caenorhabditis elegans

Seungjae Hwang, Jongsun Lee and Seung-Jae V. Lee

Molecules and Cells, 2025, 48, 100233
DOI: 10.1016/j.mocell.2025.100233

Miquelianin and spiraeoside from Filipendula ulmaria mitigate α-synuclein accumulation in C.elegans and reduce the expression of neuroinflammatory cytokines in human microglia

Martina Redl, Sabrina Weisenburger, Andreas Wasilewicz, Ulrike Grienke, Martin D. Lehner, Dirk Bredenbröker and Judith M. Rollinger

Front. Pharmacol., 2026, 16
DOI: 10.3389/fphar.2025.1720314

β-asarone protects against age-related motor decline via activation of SKN-1/Nrf2 and subsequent induction of GST-4

Ming Lei, Jiayu Wu, Yanheng Tan, Yang Shi, Wuyan Yang, Haijun Tu and Weihong Tan

Pharmacological Research, 2024, 209, 107450
DOI: 10.1016/j.phrs.2024.107450

Enhancing the Anti-Aging Potential of Green Tea Extracts Through Liquid-State Fermentation with Aspergillus niger RAF106

Yuju Liu, Xiao Zhang, Xingbing Liu, Ruixuan Li, Ximiao Yang, Zhenlin Liao, Xiang Fang and Jie Wang

Foods, 2025, 14, 3548
DOI: 10.3390/foods14203548

Beyond the root: licorice (Glycyrrhiza glabra L.) fruit extract modulates oxidative stress and apoptotic markers in PC12 cells

Parvin Jahanbani, Leila Hosseinzadeh, Matin Mahmoudi, Fereshteh Jalilian, Mahdieh Eftekhari and Masoud Modarresi

Sci Rep, 2026, 16
DOI: 10.1038/s41598-026-46382-4

Discovery of dietary beneficial compounds for healthy aging: From worm to human

Xianjiang Ye, Hao Wang, Yuxuan Han, Xing Fu, Jiuliang Zhang and Tao Zhang

Food Research International, 2025, 218, 116916
DOI: 10.1016/j.foodres.2025.116916

Phycoerythrin from Aulosira fertilissima: A bioactive macromolecule for longevity and neuroprotection in SH-SY5Y cells and Caenorhabditis elegans

Bhargavi Sonavane, Prashsti Chadha, Prasad Andhare, Shrey Dube, Niraj Kumar Singh, Palash Mandal, Seema Amin and Datta Madamwar

Biocatalysis and Agricultural Biotechnology, 2025, 69, 103795
DOI: 10.1016/j.bcab.2025.103795

Anti-aging effects of medicinal plants and their rapid screening using the nematode Caenorhabditis elegans

Xiaodan Chen, Faranak Bahramimehr, Nasim Shahhamzehei, Huangjie Fu, Siyi Lin, Hanxiao Wang, Changyu Li, Thomas Efferth and Chunlan Hong

Phytomedicine, 2024, 129, 155665
DOI: 10.1016/j.phymed.2024.155665

Anti‐Aging Activity of Rosa roxburghii Nano‐Emulsion in Caenorhabditis elegans: Preparation, Characterization, and Evaluation

Xiaowei Zhou, Xiaojuan Li, Gaigai Xu, Bing Bai and Zixiu Wang

Chemistry & Biodiversity, 2026, 23
DOI: 10.1002/cbdv.202502105

In silico transcriptome-based drug screening identifies celastrol as a multi-species therapeutic agent against aging-related sarcopenia and mitochondrial dysfunction

Bangfu Wu, Jiaxin Liu, Zhaoyu Cui, Xingzhu Yin, Li Mo, Li Chen, Huimin Chen, Xuer Cheng, Yu Wang, Fangqu Liu, Chanhua Liang, Yuna Tian, Yuxia Chen, Xiaocui Liu, Yanyan Li, Ping Yao, Chao Gao and Yuhan Tang

Journal of Advanced Research, 2026
DOI: 10.1016/j.jare.2026.01.079