Unlocking the potential of RGD-conjugated gold nanoparticles: a new frontier in targeted cancer therapy, imaging, and metastasis inhibition

Hossein Javid, Mahsa Akbari Oryani, Nastaran Rezagholinejad, Alireza Hashemzadeh and Mehdi Karimi-Shahri

J. Mater. Chem. B, 2024, 12, 10786
DOI: 10.1039/D4TB00281D

Functional peptide-assisted delivery of CRISPR/Cas9: recent progress on gene editing

Hye Min Cho, Yeong Chae Ryu, Min Kyu Cho and Byeong Hee Hwang

Biomater. Sci., 2026, 14, 3132
DOI: 10.1039/D6BM00231E

Peptides: potential delivery systems for mRNA

Huiting Liang, Yun Xing, Kexin Wang, Yaping Zhang, Feng Yin and Zigang Li

RSC Chem. Biol., 2025, 6, 666
DOI: 10.1039/D4CB00295D

Development of polypeptide-based materials toward messenger RNA delivery

Bowen Zhao, Xiao Zhang, Molly S. Bickle, Shiwei Fu, Qingchun Li and Fuwu Zhang

Nanoscale, 2024, 16, 2250
DOI: 10.1039/D3NR05635J

Nonviral targeted mRNA delivery: principles, progresses, and challenges

Xi He, Guohong Li, Letao Huang, Haixing Shi, Sha Zhong, Siyu Zhao, Xiangyu Jiao, Jinxiu Xin, Xiaoling Yin, Shengbin Liu, Zhongshan He, Mengran Guo, Chunli Yang, Zhaohui Jin, Jun Guo and Xiangrong Song

MedComm, 2025, 6
DOI: 10.1002/mco2.70035

Fine tuning of the net charge alternation of polyzwitterion surfaced lipid nanoparticles to enhance cellular uptake and membrane fusion potential

Keitaro Homma, Yutaka Miura, Motoaki Kobayashi, Wanphiwat Chintrakulchai, Masahiro Toyoda, Koichi Ogi, Junya Michinishi, Tomoyuki Ohtake, Yuto Honda, Takahiro Nomoto, Hiroyasu Takemoto and Nobuhiro Nishiyama

Science and Technology of Advanced Materials, 2024, 25
DOI: 10.1080/14686996.2024.2338785

Secondary Site Ligand for Integrin αVβ3 Enables Targeted mRNA Delivery

Sebastian Bayer, María García‐García, Raffaele Senatore, Maria Stratoudaki, Alina Markhof, Angelika Berger‐Becvar, Anna Sophia Parianou and Christoph Rademacher

Angew Chem Int Ed, 2026
DOI: 10.1002/anie.1554405

Recent advances in engineering approaches for delivery of mRNA-based therapeutics

Ken Ninez Nurpramesti Prinindya, Ghulam Md Ashraf, Shihab Uddin, Elsadig Mahdi and Anwarul Hasan

Biomaterials Advances, 2026, 182, 214667
DOI: 10.1016/j.bioadv.2025.214667

Lipid-Based Nanoparticle Functionalization with Coiled-Coil Peptides for In Vitro and In Vivo Drug Delivery

Dennis Aschmann, Renzo A. Knol and Alexander Kros

Acc. Chem. Res., 2024, 57, 1098
DOI: 10.1021/acs.accounts.3c00769

Investigation of enhanced intracellular delivery of nanomaterials modified with novel cell-penetrating zwitterionic peptide-lipid derivatives

Yuri Sugimoto, Tadaharu Suga, Mizuki Umino, Asako Yamayoshi, Hidefumi Mukai and Shigeru Kawakami

Drug Delivery, 2023, 30
DOI: 10.1080/10717544.2023.2191891

Lipid Nanoparticle (LNP) Delivery Carrier-Assisted Targeted Controlled Release mRNA Vaccines in Tumor Immunity

Liusheng Wu, Xiaoqiang Li, Xinye Qian, Shuang Wang, Jixian Liu and Jun Yan

Vaccines, 2024, 12, 186
DOI: 10.3390/vaccines12020186

Oligonucleotide‐Linked Lipid Nanoparticles as a Versatile mRNA Nanovaccine Platform

San Hae Im, Youseung Chung, Nevena Duskunovic, Heewon Choi, Su‐Hyung Park and Hyun Jung Chung

Adv Healthcare Materials, 2024, 13
DOI: 10.1002/adhm.202401868

Precision engineering of macrophage reprogramming with RNA interference-loaded lipid nanoparticles: a game-changer in cancer immunotherapy

Sezen Gül, Juliette Vergnaud, François Fay and Elias Fattal

Drug Deliv. and Transl. Res., 2025
DOI: 10.1007/s13346-025-01970-1

Smart lipid nanoparticles: the chemistry driving targeted therapeutics

Nathalie Abbrederis, Despoina Paloglou and Kira Gerber Astakhova

Trends in Chemistry, 2025, 7, 827
DOI: 10.1016/j.trechm.2025.09.011

Just Keep Rolling?—An Encompassing Review towards Accelerated Vaccine Product Life Cycles

Janis Stiefel, Jan Zimmer, Jeffrey L. Schloßhauer, Agnes Vosen, Sarah Kilz and Sascha Balakin

Vaccines, 2023, 11, 1287
DOI: 10.3390/vaccines11081287

Physiological Barriers and Strategies of Lipid‐Based Nanoparticles for Nucleic Acid Drug Delivery

Mingdi Hu, Xiaoyan Li, Zhen You, Rong Cai and Chunying Chen

Advanced Materials, 2024, 36
DOI: 10.1002/adma.202303266

LNP-Mediated CF10 Delivery Selectively Enhances Potency to Colorectal Cancer Cells and Preserves the TS/Top1 Dual Targeting Mechanism

Santu Sarkar, Akanksha Behl and William H. Gmeiner

ACS Appl. Bio Mater., 2026, 9, 1989
DOI: 10.1021/acsabm.5c01892

Peptide-based non-viral gene delivery: A comprehensive review of the advances and challenges

Kai Xiang, Yanan Li, Hailin Cong, Bing Yu and Youqing Shen

International Journal of Biological Macromolecules, 2024, 266, 131194
DOI: 10.1016/j.ijbiomac.2024.131194

Novel Lipid Nanoparticle (LNP) Delivery Systems Enabling the Advancement of RNA Therapeutics

Honglei Zhang, Shaowei Han, Xueyan Zhang, Jingxuan Ma, Lijie Jin, Yanfeng Wang, Yuqing Ma, Teng Ma, Fei Yu and Gengshen Song

Adv Healthcare Materials, 2026, 15
DOI: 10.1002/adhm.202505340

αvβ3 integrin targeting RGD peptide-based nanoparticles as an effective strategy for selective drug delivery to tumor microenvironment

Prashant Kesharwani, Jyoti Chandra, Shahid Karim, Garima Gupta, Ritu Karwasra and Ajay Sharma

Journal of Drug Delivery Science and Technology, 2024, 96, 105663
DOI: 10.1016/j.jddst.2024.105663

Examining the effect of lipid nanoparticle elasticity on endocytosis and mRNA delivery to cancer cells

Cecilia F. Shuler, Hannah C. Safford, Ajay S. Thatte, Melgious Ang and Michael J. Mitchell

Med-X, 2026, 4
DOI: 10.1007/s44258-026-00082-w

Advances in the Development of Lipid Nanoparticles for mRNA Delivery

Xing Wang, Letao Xu, Zhenwei Lan, Yue Hui, Yun Liu, Guangze Yang and Chun‐Xia Zhao

Small Structures, 2026, 7
DOI: 10.1002/sstr.202500568

Finely tuned ionizable lipid nanoparticles for CRISPR/Cas9 ribonucleoprotein delivery and gene editing

San Hae Im, Mincheol Jang, Ji-Ho Park and Hyun Jung Chung

J Nanobiotechnol, 2024, 22
DOI: 10.1186/s12951-024-02427-2

Synergistic breast cancer therapy with RGD-decorated liposomes co-delivering mir-34a and cisplatin

Hassan Bardania, Marzieh Baneshi, Reza Mahmoudi, Fatemeh Khosravani, Farshad Safari, Bahman Khalvati, Abdollah Poursamad and Mohsen Alipour

Cancer Nano, 2024, 15
DOI: 10.1186/s12645-024-00299-7

Cell-Mediated and Peptide-Based Delivery Systems: Emerging Frontiers in Targeted Therapeutics

Eszter Erdei, Ruth Deme, Balázs Balogh and István M. Mándity

Pharmaceutics, 2025, 17, 1597
DOI: 10.3390/pharmaceutics17121597

Development and applications of lipid hydrophilic headgroups for nucleic acid therapy

Wanting Ma, Xingxing Fu, Tianyi Zhao, Yanfei Qi, Shubiao Zhang and Yinan Zhao

Biotechnology Advances, 2024, 74, 108395
DOI: 10.1016/j.biotechadv.2024.108395

Nano-Enabled CRISPR-Cas Gene Editing for Cancer Therapeutics

Liangzhi Luo, Pengjun Sun, Tianyi Zhang, Ziyao Zhou, Tianle Zhang and Ziyang Hao

JNT, 2026, 7, 6
DOI: 10.3390/jnt7010006

Viral and nonviral nanocarriers for in vivo CRISPR-based gene editing

Zhongyuan Guo, Audrey T. Zhu, Ronnie H. Fang and Liangfang Zhang

Nano Res., 2024, 17, 8904
DOI: 10.1007/s12274-024-6748-5

When mRNA meets gene editing

Weijie Li, Chen Wang and Yuan Lu

Nano Res., 2024, 17, 7337
DOI: 10.1007/s12274-024-6729-8

Metal-Coordination Directs the Self-Assembly of Terpyridine-Peptide Conjugates into Multifunctional Nanoplatforms with Potent In Vitro Antitumor Effects

Zhengyu Tan, Xin Tian and Xinming Li

ACS Appl. Mater. Interfaces, 2026
DOI: 10.1021/acsami.6c06213

RGD peptide in cancer targeting: Benefits, challenges, solutions, and possible integrin–RGD interactions

Hossein Javid, Mahsa Akbari Oryani, Nastaran Rezagholinejad, Ali Esparham, Mahboubeh Tajaldini and Mehdi Karimi‐Shahri

Cancer Medicine, 2024, 13
DOI: 10.1002/cam4.6800

Enhanced neuronal transfection in the injured brain following systemic delivery of peptide-targeted lipid nanoparticles

Jason R. Wu, Yazmin Hernandez, Akash Canjels, Kit L. Bailey and Ester J. Kwon

Molecular Therapy Nucleic Acids, 2026, 37, 102817
DOI: 10.1016/j.omtn.2025.102817

Discovery of peptides for ligand-mediated delivery of mRNA lipid nanoparticles to cystic fibrosis lung epithelia

Melissa R. Soto, Mae M. Lewis, Jasmim Leal, Yuting Pan, Rashmi P. Mohanty, Arian Veyssi, Esther Y. Maier, Brittany J. Heiser and Debadyuti Ghosh

Molecular Therapy Nucleic Acids, 2024, 35, 102375
DOI: 10.1016/j.omtn.2024.102375

Formulation methods for peptide-modified lipid nanoparticles

Katelyn Miyasaki, Sangwoo Han, Olivia Carton, Rebecca M. Kandell, Jonathan Gunn and Ester J. Kwon

Journal of Controlled Release, 2025, 385, 114030
DOI: 10.1016/j.jconrel.2025.114030

Current landscape of mRNA technologies and delivery systems for new modality therapeutics

Ruei-Min Lu, Hsiang-En Hsu, Ser John Lynon P. Perez, Monika Kumari, Guan-Hong Chen, Ming-Hsiang Hong, Yin-Shiou Lin, Ching-Hang Liu, Shih-Han Ko, Christian Angelo P. Concio, Yi-Jen Su, Yi-Han Chang, Wen-Shan Li and Han-Chung Wu

J Biomed Sci, 2024, 31
DOI: 10.1186/s12929-024-01080-z

Precision treatment of viral pneumonia through macrophage-targeted lipid nanoparticle delivery

Gan Zhao, Lulu Xue, Hannah C. Geisler, Junchao Xu, Xinyuan Li, Michael J. Mitchell and Andrew E. Vaughan

Proc. Natl. Acad. Sci. U.S.A., 2024, 121
DOI: 10.1073/pnas.2314747121

Secondary Site Ligand for Integrin αVβ3 Enables Targeted mRNA Delivery

Sebastian Bayer, María García‐García, Raffaele Senatore, Maria Stratoudaki, Alina Markhof, Angelika Berger‐Becvar, Anna Sophia Parianou and Christoph Rademacher

Angewandte Chemie, 2026
DOI: 10.1002/ange.1554405

Cellular Trafficking of Nanotechnology‐Mediated mRNA Delivery

Pei Huang, Hongzhang Deng, Changrong Wang, Yongfeng Zhou and Xiaoyuan Chen

Advanced Materials, 2024, 36
DOI: 10.1002/adma.202307822

Targeted gene delivery through receptors with lipid nanoparticles

Venkanna Muripiti, Amarnath Velidandia, Yash Paul Sharma, Ramesh Gondru, C.G. Arya and Janardhan Banothu

Journal of Drug Delivery Science and Technology, 2024, 93, 105457
DOI: 10.1016/j.jddst.2024.105457

Strategies for Organ‐Targeted mRNA Delivery by Lipid Nanoparticles

Hangping Liao, Jing Liao, Ling Zeng, Xinxiu Cao, Hui Fan and Jinjin Chen

WIREs Nanomed Nanobiotechnol, 2024, 16
DOI: 10.1002/wnan.2004

An Antibody‐CRISPR/Cas Conjugate Platform for Target‐Specific Delivery and Gene Editing in Cancer

Seungju Yang, San Hae Im, Ju Yeon Chung, Juhee Lee, Kyung‐Hun Lee, Yoo Kyung Kang and Hyun Jung Chung

Advanced Science, 2024, 11
DOI: 10.1002/advs.202308763