A novel approach to investigate the combinatorial effects of TLK1 (Tousled-Like Kinase1) inhibitors with Temozolomide for glioblastoma therapy

Bhanu Priya, Dimple Chhabria, Janhvi Mahesh Dhongdi and Sivapriya Kirubakaran

Bioorganic Chemistry, 2024, 151, 107643
DOI: 10.1016/j.bioorg.2024.107643

Discovery and optimization of narrow spectrum inhibitors of Tousled like kinase 2 (TLK2) using quantitative structure activity relationships

Christopher R.M. Asquith, Michael P. East, Tuomo Laitinen, Carla Alamillo-Ferrer, Erkka Hartikainen, Carrow I. Wells, Alison D. Axtman, David H. Drewry, Graham J. Tizzard, Antti Poso, Timothy M. Willson and Gary L. Johnson

European Journal of Medicinal Chemistry, 2024, 271, 116357
DOI: 10.1016/j.ejmech.2024.116357

Characterization of new non-ATP dependent inhibitors of TLK1 as potential molecules for treating prostate cancer

Delna Johnson, Shivangi Sharma, Vijay Thiruvenkatam and Sivapriya Kirubakaran

Bioorganic Chemistry, 2025, 158, 108317
DOI: 10.1016/j.bioorg.2025.108317

Rapid on-site detection of hypochlorite: A novel phenothiazine-based fluorescent probe for environmental water monitoring and paper-based sensing

Pranjal Gulati, Shilpa Taneja, Pravinkumar Selvam, Selva Kumar Ramasamy and S.K. Ashok Kumar

Journal of Molecular Structure, 2026, 1369, 146332
DOI: 10.1016/j.molstruc.2026.146332

Autophosphorylation of the Tousled-like kinases TLK1 and TLK2 regulates recruitment to damaged chromatin via PCNA interaction

Kirk L West, Tram T N Nguyen, Kyle A Tengler, Natasha Kreiling, Kevin D Raney, Gargi Ghosal and Justin W Leung

Nucleic Acids Research, 2025, 53
DOI: 10.1093/nar/gkae1279

Biochemical and Structural Studies of Protein Tyrosine Phosphatase PTP‐PEST (PTPN12) in Search of Small Molecule Inhibitors

Delna Johnson, Madhulika Dixit and Sivapriya Kirubakaran

Chem Biol Drug Des, 2025, 105
DOI: 10.1111/cbdd.70058

ER‐Specific Localization and Stress Detection With Phenothiazine Nucleoside Fluorescent Probes

Gayatri Bhattad, Rajesh Sahu, Mohini Ghorpade, Yogesh S. Sanghvi, Anant R. Kapdi and Sriram Kanvah

Chemistry An Asian Journal, 2025, 20
DOI: 10.1002/asia.202500433

Targeting Prostate Cancer, the ‘Tousled Way’

Siddhant Bhoir and Arrigo De De Benedetti

IJMS, 2023, 24, 11100
DOI: 10.3390/ijms241311100