Platycodon D reduces obesity and non-alcoholic fatty liver disease induced by a high-fat diet through inhibiting intestinal fat absorption

Xingkui Tang, Yi Yang, Wenxu Peng, Mengping Xu, Qitong Fan, Feng Li, Guorong Zou and Jianlin Zhu

Front. Pharmacol., 2024, 15
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Nanoplastic-Induced Liver Damage Was Alleviated by Maltol via Enhancing Autophagic Flow: An In Vivo and In Vitro Study

Ying Liang, Zi Wang, Deyang Huo, Jun-nan Hu, Lingjie Song, Xiaochi Ma, Shuang Jiang and Wei Li

J. Agric. Food Chem., 2024, 72, 16250
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Anti-Diabetic Effect of Lactobacillus Paracasei Isolated from Malaysian Water Kefir Grains

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Probiotics & Antimicro. Prot., 2024, 16, 2161
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A Novel Edible Eutectogel Containing Baicalein and 1‐Deoxynojirimycin Alleviates Type 2 Diabetes Mellitus

Naijun Dong, Nasha Wu, Shu Huang, Yuesheng Dong and Zhilong Xiu

Journal of Food Science, 2026, 91
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Diabetic encephalopathy models: A systematic review from cells to animals

Yongjie Xu, Changyudong Huang, Yiqiong Zhang, Haizhi Li, Huiru Yang, Mi Liu, Liying Zhu, Chengcheng Li, Yinxue Zhong, Lei Tang, Shuyun Zhao and Wei Pan

Experimental Neurology, 2026, 395, 115477
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Platycodin D attenuates diabetic renal ischemia/reperfusion injury by enhancing mitophagy and suppressing MAPK/NF-κB signaling activation

Xuke Qin, Jin Liu, Xiaojie Zhao, Lei Wang, Xiuheng Liu and Zhiyuan Chen

Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, 2025, 1871, 168026
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Oxidative stress and mitochondrial dysfunction contribute to pulmonary impairment in a murine model of type 2 diabetes mellitus

Rohit Bansal, Akhil Akhil, Preety Kumari, Amarjit S. Naura and Archana Bhatnagar

Tissue and Cell, 2026, 101, 103397
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Research progress on extraction and purification, pharmacological activity, pharmacokinetics and content determination of platycodin D

Longzhu Yang, Xin Xiao, Xinchuan Chai, Zitong Yin, Dongdong Zhang, Hao Fan, Wei Wang, Yuze Li and Xiaomei Song

Med Chem Res, 2025, 34, 2513
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Pharmacology-Driven Dissection of Core Component Sets of Xuefu Zhuyu Decoction in Blood Stasis-Related Cardiovascular Diseases

Xuyang Dai, Dongsheng Ba, Miansheng Gao, Chen Liang, Ximeng Zhang, Huijuan Yu, Xin Chai and Yuefei Wang

Pharmaceuticals, 2026, 19, 532
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Static training improves insulin resistance in skeletal muscle of type 2 diabetic mice via the IGF-2/IGF-1R pathway

Lizhen Gan, Pei Chen, Zhi Zhang, Xinyi He, Xia Wu, Zhewei Chen, Qingbo Wei and Yunchuan Wu

Sci Rep, 2025, 15
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DHLCA Alleviates Diabetic Kidney Disease via TGR5/FXR Activation and Gut Microbiota Remodeling

Hua Zhou, Xiaodie Mu, Huiyue Hu, Shuya Zhao, Nan Hu, Min Yang and Jingting Jiang

DDDT, 2025, Volume 19, 6469
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Platycodin D Ameliorates Type 2 Diabetes-Induced Myocardial Injury by Activating the AMPK Signaling Pathway

Wenting Wang, Zi Wang, Zhaojie Meng, Shuang Jiang, Zhi Liu, Hong-yan Zhu, Xin-dian Li, Jing tian Zhang and Wei Li

J. Agric. Food Chem., 2024, 72, 10339
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Lignan constituents with α-amylase and α-glucosidase inhibitory activities from the fruits of Viburnum urceolatum

Jia Chen, Yiyuan Tang, Hongjuan Zhou, Jianhua Shao, Wei Ji, Zihan Wang, Dong Liang and Chunchao Zhao

Phytochemistry, 2023, 216, 113895
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Sulfosuccinimidyl oleate ameliorates the high-fat diet-induced obesity syndrome by reducing intestinal and hepatic absorption

Qiming Ma, Li Wen, Yanxia Tian, Liqin Ma, Zhangsheng Wen, Yang Kun, Mengping Xu and Xiaoping Liu

Front. Pharmacol., 2023, 14
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Ginseng-derived GABAFG ameliorates type 2 diabetes mellitus by modulating autophagy-lysosome pathway and gut microbiota

Meng-han Qi, Hai-yan Zhang, Yun-yi Hou, Ivan Steve Nguepi Tsopmejio, Wei Liu, Wen-guang Chang, Chen Chen, Zi Wang and Wei Li

Journal of Advanced Research, 2025, 77, 465
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Selenium-rich yeast improve HFD-induced abnormal lipid metabolism in ApoE −/− mice: inhibit oxidative stress, reorganise gut microbiota, and enhance cognitive ability

Rui Liu, Songxue Wang, Zhifu Liu, Qian Cheng, Qiuyuan Liang, Jian Du, Huali Wang, Ye Zhang and Hao Wang

International Journal of Food Sciences and Nutrition, 2025, 76, 404
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Platycodin D Improves Early Atherosclerosis in Type 2 Diabetes Mellitus by Regulating Endothelial Inflammation and Apoptosis

Zi Wang, Yu Dong, Yu-Ying Bai, Jing-Tian Zhang, Le-Qi Wang, Shen Ren, Xin-Dian Li, Jun-Nan Hu and Wei Li

Am. J. Chin. Med., 2025, 53, 1887
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Hypoglycemic effects of white hyacinth bean polysaccharide on type 2 diabetes mellitus rats involvement with entero-insular axis and GLP-1 via metabolomics study

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International Journal of Biological Macromolecules, 2024, 281, 136489
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Platycodin D inhibits HFD/STZ-induced diabetic nephropathy via inflammatory and apoptotic signaling pathways in C57BL/6 mice

Qiong Shen, Si-min Qi, Jing-tian Zhang, Ming-han Li, Ying-ping Wang, Zi Wang and Wei Li

Journal of Ethnopharmacology, 2023, 314, 116596
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The pharmacology and mechanisms of platycodin D, an active triterpenoid saponin from Platycodon grandiflorus

Long Xie, Yu-Xin Zhao, Yu Zheng and Xiao-Fang Li

Front. Pharmacol., 2023, 14
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The polysaccharides from seeds of Glycyrrhiza uralensis ameliorate metabolic disorders and restructure gut microbiota in type 2 diabetic mice

Jianming Ye, Jie Ma, Parhat Rozi, Lingming Kong, Jianzhong Zhou, Yane Luo and Haiyan Yang

International Journal of Biological Macromolecules, 2024, 264, 130622
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Natural products targeting AMPK signaling pathway therapy, diabetes mellitus and its complications

Min Li, Lu Ding, Liyuan Cao, Zepeng Zhang, Xueyan Li, Zirui Li, Qinjing Xia, Kai Yin, Siyu Song, Zihan Wang, Haijian Du, Daqing Zhao, Xiangyan Li and Zeyu Wang

Front. Pharmacol., 2025, 16
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Implement enhanced artificial “enteroendocrine L cells” via oral administration for effective treatment of type 2 diabetes

Xiaomin Chen, Ying Zhang, Tingtao Chen, Haihua Ji, Jing Liu, Lin Yang, Li Zhang, Pengcheng Xie, Qi Zhou and Hao Wan

Cell Biomaterials, 2025, 1, 100024
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Dehydrolithocholic Acid (DHLCA) Ameliorates Diabetic Kidney Disease by Activating TGR5/FXR Signaling and Remodeling the Gut Microbiota

Liam Wilson, Noah Baker and Ava Turner

Pharm Sci Drug Des, 2022, 2, 130
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Multifaceted therapeutic potential of saponins in type 2 diabetes mellitus: mechanisms targeting insulin resistance and diabetic complications

Yuan Yuan, Ke-Ying Shou, Si-Qi Wu, Jing-Yu Zhao, Yao Liu, Ya-Jun Wang, Hua-Song Luo and Wen-Ting Dai

Front. Pharmacol., 2026, 17
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Targeting the gut microbiota and lipid metabolism: potential mechanisms of natural products for the treatment of non-alcoholic fatty liver disease

Yutian Zhang, Tianlin Wang, Junquan Han, Jielin Song, Chaoshuai Yang, Lei Liang, Huizhen Li and Hong Wang

Front. Pharmacol., 2025, 16
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Ameliorating effects of Porphyra tenera ethanol extract on obesity, dyslipidemia, and hepatic lipid metabolism in high-fat diet-induced obese mice

Suyeon Lee, Jinhan Park, Chounghun Kang, Kyung Ju Lee and Dayeon Shin

J Nutr Health, 2024, 57, 590
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Research on the effects of intestinal FXR agonists and antibiotics on the regulation of red kidney bean polysaccharides in the liver metabolism in mice with type 2 diabetes

Yunhui Zhang, Caili Qi, Xingguo Li, Mengyuan Geng, Honglin Lan, Yifang Wei, Denglin Luo, Zhouya Bai, Jinying Guo and Sihai Han

eFood, 2024, 5
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Tryptophan and polyamine metabolism dysregulation serves as an early marker of high-fat diet-induced glucose intolerance

Jianfang Gao, Li Zhang, Shumin Zhan, Zhou Peng, Juan Du, Zhongxiao Zhang, Liling Xu, Shan Huang, Xingyun Wang and Xirong Guo

Journal of Lipid Research, 2026, 67, 100980
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Trigonella foenum-graecum L. ameliorates metabolism-associated fatty liver disease in type 2 diabetic mice: a multi-omics mechanism analysis

Luxuan Chi, Hongjuan Niu, Yang Niu, Rongfei Yao, Dongxu Shi, Binan Lu and Zongran Pang

Journal of Ethnopharmacology, 2025, 348, 119862
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Hesperetin-copper (II) complex improves liver glucose metabolism by regulating the IRS-1/PI3K/AKT signaling pathway in T2DM mice

Xi Peng, Yushi Wei, Deming Gong and Guowen Zhang

Food Bioscience, 2024, 62, 105408
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Phage cocktail alleviated type 2 diabetes by reshaping gut microbiota and decreasing proinflammatory cytokines

Jianming Ye, Qiang Meng, Kezhu Jin, Yane Luo and Tianli Yue

Appl Microbiol Biotechnol, 2024, 108
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Platycodin D Ameliorates Cognitive Impairment in Type 2 Diabetes Mellitus Mice via Regulating PI3K/Akt/GSK3β Signaling Pathway

Ya-wei Lu, Li-ya Xie, Meng-han Qi, Shen Ren, Yue-qi Wang, Jun-nan Hu, Zi Wang, Shan Tang, Jing-tian Zhang and Wei Li

J. Agric. Food Chem., 2024, 72, 12516
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Ferroptosis: a new strategy for Chinese herbal medicine treatment of diabetic nephropathy

Maoying Wei, Xingxing Liu, Zhijuan Tan, Xiaochan Tian, Mingdi Li and Junping Wei

Front. Endocrinol., 2023, 14
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Platycodin D ameliorates antibiotic-associated diarrhea by modulating the PI3K/AKT/NF-κB pathway and regulating gut microbiota and metabolism

Mohan Zhang, Liwen Qin, Xiao Yang, Qi An, Yanbing Zou, Shuqi Wang, Hongjie Piao, Yuping Wen, Hushan Cui and Qing Jin

International Immunopharmacology, 2026, 181, 116748
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