Mechanochemistry-directed ligand design for enhanced reactivity and enantioselectivity in solve-less palladium-catalyzed conjugate arylations

Keisuke Kondo, Hina Shoji, Koji Kubota and Hajime Ito

RSC Mechanochem., 2026
DOI: 10.1039/D6MR00032K

Solvent-less mechanochemical asymmetric reactions in a ball mill utilizing a polymer-supported Hayashi–Jørgensen catalyst: effects of the polymer backbone and flexibility on its catalytic performance

Kento Hiroishi, Hikaru Matsumoto, Hidetaka Kasai, Masanori Nagao, Eiji Nishibori and Yoshiko Miura

Green Chem., 2026, 28, 3141
DOI: 10.1039/D5GC05291B

Mechanochemical aerobic oxidative Heck coupling by polymer-assisted grinding: cyclodextrin additive facilitating regioselectivity control

Keyu Xiang, Haowen Shou, Chenhui Hu, Weike Su and Jingbo Yu

Green Chem., 2024, 26, 5890
DOI: 10.1039/D4GC01006J

Building a cost-effective mechanochemical Raman system: improved spectral and time resolution for in situ reaction and rheology monitoring

Goran Zgrablić, Ana Senkić, Noa Vidović, Krunoslav Užarević, Davor Čapeta, Ivana Brekalo and Mario Rakić

Phys. Chem. Chem. Phys., 2025, 27, 5909
DOI: 10.1039/D4CP04757E

When mechanochemistry meets fluorine

Vishal B. Purohit, Ronak V. Prajapati, Vaibhav D. Prajapati, Dmitry Katayev, Satenik Mkrtchyan and Viktor O. Iaroshenko

Chem. Commun., 2026, 62, 8327
DOI: 10.1039/D6CC01414C

Harnessing the copper surface for direct mechanocatalysis: a case study on mechanochemical sulfonylurea synthesis

Kathleen R. Floyd, Lizette S. Mella, Ryan W. Kwok, Mackenzie Gray, Edward J. Broker, Mateusz Marianski, Tomislav Friščić and James D. Batteas

Chem. Sci., 2025, 16, 19830
DOI: 10.1039/D5SC04099J

Electromagnetic mill promoted mechanochemical palladium-catalyzed solid state cyanation of aryl bromides using non-toxic K4[Fe(CN)6]

Yanan Hou, Hui Wang, Juan Xi, Ruonan Jiang, Lizhi Zhang, Xinjin Li, Fenggang Sun, Qing Liu, Zengdian Zhao and Hui Liu

Green Chem., 2023, 25, 2279
DOI: 10.1039/D2GC04506K

Synthesis without solvent: consequences for mechanochemical reactivity

Lauren E. Wenger and Timothy P. Hanusa

Chem. Commun., 2023, 59, 14210
DOI: 10.1039/D3CC04929A

Scratching beneath the surface: catalyst evolution and reusability in the direct mechanocatalytic Sonogashira reaction

Sheeniza Shah, Mennatullah M. Mokhtar, Thinh Tran, Kathleen Floyd, Lizette Mella, Tim Dao, Alexandria Garza, James Batteas and James Mack

RSC Mechanochem., 2026, 3, 46
DOI: 10.1039/D5MR00060B

Helical-structure transition and color changes in aromatic polyacetylenes under mechanochemical conditions: effect of the additive-alcohol chain length

Haruki Ikushima and Yasuteru Mawatari

RSC Mechanochem., 2026, 3, 38
DOI: 10.1039/D5MR00102A

Recent Advances in the Creation of Supramolecular Assemblies by Polymer‐Aided Co‐Crystallization Approach

Ananya Kar, Lopamudra Giri, T. Nalinikanta Patra and Rambabu Dandela

ChemistrySelect, 2025, 10
DOI: 10.1002/slct.202505073

Liquid‐Assisted Grinding in Medicinal Mechanochemistry: A Pathway to Enhanced Reactivity and Selectivity

Yuxin Fang and Jingbo Yu

Adv Synth Catal, 2026, 368
DOI: 10.1002/adsc.70372

Barbier Reactions with Gaseous CO2 via Electromagnetic Milling

Hui Wang, Fachao Yan, Yanan Hou, Long Shu, Xiaowei Li, Mingxia Zhang, Hongyou Cui and Hui Liu

Adv Synth Catal, 2025, 367
DOI: 10.1002/adsc.70061

Monoselective Mechanochemical Aromatic Nucleophilic Substitution Enabled by Crystal‐Engineering‐Guided Reaction Design

Sota Kawamura, Hikaru Yamamoto, Mingoo Jin, Koji Kubota and Hajime Ito

Angew Chem Int Ed, 2026, 65
DOI: 10.1002/anie.2656827

Mechanochemistry-Directed Ligand Design: Development of a High-Performance Phosphine Ligand for Palladium-Catalyzed Mechanochemical Organoboron Cross-Coupling

Tamae Seo, Koji Kubota and Hajime Ito

J. Am. Chem. Soc., 2023, 145, 6823
DOI: 10.1021/jacs.2c13543

Nickel-Catalyzed Cross-Coupling of Aryl Chlorides by Heated Mechanochemistry: Scalable Suzuki–Miyaura Reactions via Twin-Screw Extrusion

Sarah E. Raby-Buck, Renan R. Mattioli, Robert R. A. Bolt, Katharine Ingram, Julio C. Pastre and Duncan L. Browne

JACS Au, 2025, 5, 6052
DOI: 10.1021/jacsau.5c00934

Alkaline‐Earth Metal Mediated Benzene‐to‐Biphenyl Coupling

Jonathan Mai, Michael Morasch, Dawid Jędrzkiewicz, Jens Langer, Bastian Rösch and Sjoerd Harder

Angew Chem Int Ed, 2023, 62
DOI: 10.1002/anie.202212463

Mechanochemical ATRP: An asset for the bulk copolymerization of solid and liquid monomers

Joao Tanepau, Sylvain Caillol, Patrick Lacroix-Desmazes, Frédéric Lamaty, Xavier Bantreil and Julien Pinaud

European Polymer Journal, 2026, 248, 114607
DOI: 10.1016/j.eurpolymj.2026.114607

Using Near‐Infrared Irradiation for Heating Mechanochemical Reactions in Organic‐Dye‐Doped Epoxy Milling Jars

Joao Tanepau, Hafsa Bonnaanaa, Angèle Macé, Arthur Guérin, Philibert Lenormand, Frédéric Lamaty, Julien Pinaud and Xavier Bantreil

Angewandte Chemie, 2025, 137
DOI: 10.1002/ange.202419354

Achieving Regioselective Control for Mechanochemical Reactions: A Planetary Ball‐Milling, Ru‐Catalyzed Synthesis of 3,4‐ and 3,4,5‐Isoxazoles

Rafael A. Hernandez R., Negin Nabavi, Stephanie J. Patterson and Pat Forgione

ChemCatChem, 2024, 16
DOI: 10.1002/cctc.202400406

Alkaline‐Earth Metal Mediated Benzene‐to‐Biphenyl Coupling

Jonathan Mai, Michael Morasch, Dawid Jędrzkiewicz, Jens Langer, Bastian Rösch and Sjoerd Harder

Angewandte Chemie, 2023, 135
DOI: 10.1002/ange.202212463

Using Near‐Infrared Irradiation for Heating Mechanochemical Reactions in Organic‐Dye‐Doped Epoxy Milling Jars

Joao Tanepau, Hafsa Bonnaanaa, Angèle Macé, Arthur Guérin, Philibert Lenormand, Frédéric Lamaty, Julien Pinaud and Xavier Bantreil

Angew Chem Int Ed, 2025, 64
DOI: 10.1002/anie.202419354

Monoselective Mechanochemical Aromatic Nucleophilic Substitution Enabled by Crystal‐Engineering‐Guided Reaction Design

Sota Kawamura, Hikaru Yamamoto, Mingoo Jin, Koji Kubota and Hajime Ito

Angewandte Chemie, 2026
DOI: 10.1002/ange.2656827

Shaking Up Photochemistry: The Future Frontiers of Mechanophotocatalysis

Francis Millward and Eli Zysman-Colman

ACS Cent. Sci., 2026, 12, 17
DOI: 10.1021/acscentsci.5c01770

Mechanochemical Synthesis of Arylsilanes via Barbier‐Type Reaction between Aryl Halides and Chlorosilanes with Magnesium

Lianze Zong, Ruizhi Sun, Xixi Hu, Jiarui Zhang, Yanbin Luan, Zhengbao. Xu, Caixia Xie, Xinjin Li, Feng‐Gang Sun, Hui Liu, Zhong‐Quan Liu, Zengdian Zhao and Lizhi Zhang

Adv Synth Catal, 2024, 366, 1509
DOI: 10.1002/adsc.202301244

Progress toward sustainable polymer technologies with ball-mill grinding

Antonio Rizzo and Gregory I. Peterson

Progress in Polymer Science, 2024, 159, 101900
DOI: 10.1016/j.progpolymsci.2024.101900

Exciplex‐Forming Cohost Systems with 2,3‐Dicyanopyrazinophenanthrene‐based Acceptors to Achieve Efficient Near Infrared OLEDs

Guan‐Cheng Liu, Tzu‐Hao Huang, Hao‐Wen Wang, Chao‐Hsien Hsu, Pi‐Tai Chou, Wen‐Yi Hung and Ken‐Tsung Wong

Chemistry A European J, 2023, 29
DOI: 10.1002/chem.202203660

Chemical and Enzymatic Mechanosynthesis of Organocatalytic Peptide Materials Based on Proline and Phenylalanine

Alexandra Rios‐Echeverri, Carlos E. Puerto Galvis, Karen J. Ardila‐Fierro and José G. Hernández

ChemSusChem, 2025, 18
DOI: 10.1002/cssc.202402446