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Conformation-Dependent Complexation Interactions for a SMARCA2 PROTAC and Cyclodextrin

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In Vivo Self‐Assembly of PROTACs by Bioorthogonal Chemistry for Precision Cancer Therapy

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Delivering on Cell‐Selective Protein Degradation Using Chemically Tailored PROTACs

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Therapeutic targeting of CDK12: a medicinal chemistry perspective

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Targeting ferroptosis: Paving new roads for drug design and discovery

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Sirtuin 3 as a promising target in disease therapy: Model action and drug discovery

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Next-generation drug conjugates for breast cancer: Clinical prospects and mechanism-based strategies to overcome resistance

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Small molecules targeting selected histone methyltransferases (HMTs) for cancer treatment: Current progress and novel strategies

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Site-Specific Antibody Conjugation with Payloads beyond Cytotoxins

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Innovations in Antibody-Drug Conjugate (ADC) in the Treatment of Lymphoma

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Development of Ligands and Degraders Targeting MAGE-A3

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Application of Artificial Intelligence and Computational Biology in Protein Drug Development

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Welding PROxAb Shuttles: A Modular Approach for Generating Bispecific Antibodies via Site-Specific Protein–Protein Conjugation

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Antibody-drug conjugates: the paradigm shifts in the targeted cancer therapy

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Opportunities and Challenges in Antibody–Drug Conjugates for Cancer Therapy: A New Era for Cancer Treatment

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Sequencing of antibody drug conjugates in breast cancer: Evidence gap and future directions

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Antibody Drug Conjugates (ADCs): Shaping the Future of Precision Oncology

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Autophagy receptor-inspired chimeras: a novel approach to facilitate the removal of protein aggregates and organelle by autophagy degradation

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Novel strategies and promising opportunities for targeted protein degradation: An innovative therapeutic approach to overcome cancer resistance

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Multicomponent Stapling of Glucagon‐Like Peptide‐1 Enables Receptor‐Guided PROTAC Delivery

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Angewandte Chemie, 2026
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Antibody-Coupled Drugs in HER2-Positive Gastric Cancer

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JBM, 2023, 11, 9
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Development of therapeutic antibodies for the treatment of diseases

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Mol Biomed, 2022, 3
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Antibody-drug conjugates (ADCs): “Smart Missiles” targeting cancer therapy

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Application of Novel Degraders Employing Autophagy for Expediting Medicinal Research

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Antibody engineering approaches toward optimization of antibody-drug conjugates

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Targeting the Undruggable: Recent Progress in PROTAC-Induced Transcription Factor Degradation

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Emerging methods to improve PROTAC transport across cell membrane

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Spotlight on ideal target antigens and resistance in antibody-drug conjugates: Strategies for competitive advancement

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Antibody-drug conjugates as multimodal therapies against hard-to-treat cancers

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Non-clinical safety evaluations of next-generation therapeutic antibodies

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Delivering on the promise of protein degraders

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Fifty years of monoclonals: the past, present and future of antibody therapeutics

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CRBN‐PROTACs in Cancer Therapy: From Mechanistic Insights to Clinical Applications

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High‐Throughput Miniaturized Synthesis of PROTAC‐Like Molecules

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Cancer Biology of GSPT1: Mechanisms and Targeted Therapy Opportunities of Molecular Glue Degraders

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Advanced Science, 2025, 12
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ELiAH: the atlas of E3 ligases in human tissues for targeted protein degradation with reduced off-target effect

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Protein degraders enter the clinic — a new approach to cancer therapy

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Aptamer-Based Targeted Protein Degradation

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ACS Nano, 2023, 17, 6150
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CELMoD–antibody conjugates unlock a CD38 feedback loop in multiple myeloma

Jian Jin

Acta Pharmaceutica Sinica B, 2025, 15, 6739
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Active targeting strategies for PROTAC delivery in cancer therapy: Advances, challenges, and future perspectives

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Applications of Precise Chemistry in Drug Discovery★

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Chinese Journal of Organic Chemistry, 2025, 45, 3075
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Reinventing chemotherapy

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The Emergence of Oligonucleotide Building Blocks in the Multispecific Proximity-Inducing Drug Toolbox of Destruction

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Proteolysis-Targeting Chimera (PROTAC) Delivery into the Brain across the Blood-Brain Barrier

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Targeted protein degradation in hematologic malignancies: clinical progression towards novel therapeutics

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Targeted degradation of LRG1 to attenuate renal fibrosis

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Antibody-Drug Conjugates: Recent Advances

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Engineering nano-PROTAC platforms: Self-assembly, stimuli-responsiveness, and targeted delivery for precision therapy

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Targeting the undruggables—the power of protein degraders

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Next steps for targeted protein degradation

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What influences the activity of Degrader−Antibody conjugates (DACs)

Yaolin Guo, Xiaoxue Li, Yang Xie and Yuxi Wang

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A Novel Paradigm for Targeting Challenging Targets: Advancing Technologies and Future Directions of Molecular Glue Degraders

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Degrader–Antibody Conjugates: Emerging New Modality

Ki Bum Hong and Hongchan An

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Expanding the horizons of targeted protein degradation: A non-small molecule perspective

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PROTAC Technology as a New Tool for Modern Pharmacotherapy

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Molecules, 2025, 30, 2123
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A Versatile Bioorthogonal Theranostic Platform Enables Relay Activation of Tumor Cell Imaging and Targeted Protein Degradation

Feilong Sun, Tian Wang, Pengfei Wang, Jiaxin Shi, Yanyan Shen, Guilong Wang, Biyu Yang, Huiwen Li, Qiumeng Zhang, Yi Chen and Xuan Zhang

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