Umpolung α-regioselective 1,3-dipolar cycloaddition and internal recycle of byproduct as two key strategies: access to diverse chiral bipyridines

Yu-Heng Wang, Xi-Rui Wang, Ke-Lan Xu, Zi-Yue Chen, Bo-Wen Pan, Li-Jun Peng, Ying Zhou and Xiong-Li Liu

Org. Chem. Front., 2023, 10, 5428
DOI: 10.1039/D3QO01144E

Zinc(ii)-catalysed cyclocondensation of oxime ethers triggered by polarity inversion: construction of fused pyrroles

Norihiko Takeda, Sora Fujita, Kaho Murakami, Chihiro Honda, Hina Tomoda, Motohiro Yasui, Takahiro Yamada and Masafumi Ueda

Chem. Commun., 2025, 61, 7995
DOI: 10.1039/D5CC01362C

Unraveling the mechanism and probing the origins of stereocontrol in a cobalt-catalyzed carboamination reaction

Yu-Nuo Wang, Sai-Bo Cao and Yang Wang

Org. Chem. Front., 2026, 13, 3189
DOI: 10.1039/D6QO00119J

One-pot synthesis of functionalized dihydropyridin-2-ones via carbene-catalyzed base-controlled [3+3] annulation reaction

Zhan-Yong Wang, Guoyang Ma, Yaoyao Xu, Qingqing Wang, Mengru Zhang, Xueji Ma, Chenyang Ma, Aili Sun, Ran Xia and Hongxin Liu

Chem. Commun., 2024, 60, 11327
DOI: 10.1039/D4CC03521F

Formation of N,N,N′,N′-tetramethylethylenediamine via coupling of the two charge reversed C–N bonds of Me3NO in the presence of an Eu(ii) bis(trimethylsilyl)amide complex

Yangjuan Li and Yu Gong

Dalton Trans., 2024, 53, 5342
DOI: 10.1039/D4DT00061G

Palladium-catalyzed enantioselective arylation of trichloro- or tri-/difluoroacetaldimine precursors

Jian Wei, Zhongjian Du, Xu Wang, Chenlei Ji, Longji Li and Yang’en You

Chem. Commun., 2024, 60, 3303
DOI: 10.1039/D4CC00022F

Transition metal promoted Brook rearrangement and its related reactions

Fazhou Yang, Jinbao Wang, Yujie Dong, Nianci Zhang and Cheng Zhang

Tetrahedron, 2024, 168, 134351
DOI: 10.1016/j.tet.2024.134351

Asymmetric Synthesis of Chiral Diamines via a Low-Loading Ir-Catalyzed Umpolung Allylation of Imines

Rong Shi, Yingwei Wang, Hongbao Sun and Dawen Niu

Org. Lett., 2025, 27, 8275
DOI: 10.1021/acs.orglett.5c02466

Quantum-Chemical Study of the Assembly Mechanism of 1-Pyrrolines from N-Benzylaldimines and Arylacetylenes in KOtBu/DMSO Superbasic Medium

Vladimir B. Orel, Andrey A. Zubarev, Ivan A. Bidusenko, Igor A. Ushakov and Nadezhda M. Vitkovskaya

J. Org. Chem., 2023, 88, 7058
DOI: 10.1021/acs.joc.3c00333

Copper-Catalyzed Enantioselective 1,3-Dipolar Cycloaddition Enabled by a Ketimine-Based Umpolung Strategy

Hui-Ling Qian, Hong-Dan Deng, Lei Yang, Zhen-Hua Wang, Yong You, Wenjing Zhang, Wei-Cheng Yuan and Jian-Qiang Zhao

ACS Catal., 2025, 15, 17591
DOI: 10.1021/acscatal.5c06243

Practical One‐Pot Multistep Synthesis of 2H‐1,3‐Benzoxazines Using Copper, Hydrogen Peroxide, and Triethylamine

Rachel Trammell, Alexandra Cordova, Shuming Zhang, Sunipa Goswami, Richel Murata, Maxime A. Siegler and Isaac Garcia‐Bosch

Eur J Org Chem, 2021, 2021, 4536
DOI: 10.1002/ejoc.202100783

Synthesis of gem-Difluorohomoallyl Amines via a Transition-Metal-Free Defluorinative Alkylation of Benzyl Amines with Trifluoromethyl Alkenes

Man Ren, Shengjiao Yu, Xuefeng Li, Wenlong Yuan, Ji Lu, Ying Xiong, Hongliang Liu, Jun Wang and Jun Wei

J. Org. Chem., 2024, 89, 8342
DOI: 10.1021/acs.joc.4c00084

Catalytic Asymmetric Umpolung Tandem Reactions of Hemiacetals via Dinuclear Zinc Cooperative Catalysis

Sheng-Nan Xing, Yuan-Zhao Hua, Xiao-Chao Yang, Si-Si Du, Shi-Kun Jia, Guang-Jian Mei and Min-Can Wang

Org. Lett., 2022, 24, 3909
DOI: 10.1021/acs.orglett.2c00913

Asymmetric Umpolung (3+2) Cycloadditions of Iminoesters with α,β-Unsaturated-2-acyl Imidazoles for the Synthesis of Substituted Pyrrolidines

Mamta Gill, Arko Das and Vinod K. Singh

Org. Lett., 2022, 24, 5629
DOI: 10.1021/acs.orglett.2c01438

Copper-Catalyzed Intramolecular Aldehyde–Ketone Nucleophilic Additions for the Synthesis of Chromans Bearing a Tertiary Alcohol Motif

Chenghao Zhu, Wenbo Jiang and Da Ma

J. Org. Chem., 2024, 89, 1220
DOI: 10.1021/acs.joc.3c02365

Recent Advances in Radical Coupling Strategies Enabled by 2‐Azaallyl Anions as Super‐Electron‐Donors

Dong Zou., Wei Wang and Jie Ying

Adv Synth Catal, 2024, 366, 1450
DOI: 10.1002/adsc.202301436

Reactivity Umpolung of the C═N Bond in Quinoxaline Scaffold Enabling Direct Nucleophilic Attack of Alkyl Grignard Reagents at the N-Terminus

Yun Peng, Lailin Chen, Hanyang Bao, Bingwei Zhou, Huayue Wu and Yunkui Liu

Org. Lett., 2022, 24, 3982
DOI: 10.1021/acs.orglett.2c01385

Visible Light‐induced Organophotocatalytic Umpolung C(sp3)‐H Functionalization of Barbituric Acids

Priyanka Nath, Mohit L. Deb, Jayanta Kumar Nath and Pranjal K. Baruah

Asian J Org Chem, 2025, 14
DOI: 10.1002/ajoc.70226

Trivalent Phosphine‐Catalyzed Reactions Using Fluorinated Building Blocks

Yi‐Chao Li, Yu‐Hao Wang, Subarna Jyoti Kalita and Yi‐Yong Huang

Adv Synth Catal, 2023, 365, 2487
DOI: 10.1002/adsc.202300381

Deoxygenative Nucleophilic Phosphonation and Electrophilic Alkylation of Secondary Amides: A Facile Access to Quaternary α-Aminophosphonates

Jiaxiang Lu, Zhenghua Li and Li Deng

J. Am. Chem. Soc., 2024, 146, 4357
DOI: 10.1021/jacs.3c14517

Umpolung Approach for the α-Alkylation of Benzylic Amines Enabled by Superelectron Donors

Wenjuan Xiao, Wen Liu, Xi Chen, Changping Fang, Mengtao Ma and Binlin Zhao

Org. Lett., 2025, 27, 10874
DOI: 10.1021/acs.orglett.5c03506

Copper-Catalyzed Umpolung of N-2,2,2-Trifluoroethylisatin Ketimines for the Enantioselective 1,3-Dipolar Cycloaddition with Benzo[b]thiophene Sulfones

Wei-Cheng Yuan, Lei Yang, Jian-Qiang Zhao, Hong-Yan Du, Zhen-Hua Wang, Yong You, Yan-Ping Zhang, Jiabin Liu, Wenjing Zhang and Ming-Qiang Zhou

Org. Lett., 2022, 24, 4603
DOI: 10.1021/acs.orglett.2c01716