Selective radical defluorinative germylation and hydrogermylation of α-trifluoromethylalkenes

Shuoshuo Zhang, Haibin Xiao, Yanjun Wu, Yue Zhang, Ling Jin, Junhao Chen and Xiaolei Huang

Org. Chem. Front., 2026
DOI: 10.1039/D6QO00391E

Visible-light-induced defluorinative allylation of difluoromethyl ketones using alkylamines as bifunctional agents

Xiaorui Jiao, Zhonghou Huang, Weidong Meng, Shengqing Zhu and Lingling Chu

Org. Chem. Front., 2023, 10, 4542
DOI: 10.1039/D3QO00870C

Room temperature deoxofluorination of aromatic aldehydes with XtalFluor-E under highly concentrated conditions

Olivier Thibeault, Marie-Rose Ouellet-Du Berger, Marie Gonay and Jean-François Paquin

Org. Biomol. Chem., 2023, 21, 6115
DOI: 10.1039/D3OB00859B

Radical-mediated [3 + 2 + 1] annulation of α-polyfluoromethyl alkenes with arylisocyanates enabled by C(sp3)–F activation

Yu-Zhong Yang, Qi Xue, Qing Sun, Yang Li, Ming Hu, Chong-Hui Xu and Jin-Heng Li

Org. Chem. Front., 2024, 11, 1305
DOI: 10.1039/D3QO02054A

Mild defluorinative N-acrylation of amines with (trifluoromethyl)alkenes: synthesis of α-arylacrylamides

Yuqi Li, Rongbin Peng, Zhaolong Ma, Zhihui Wang and Chuanle Zhu

Org. Biomol. Chem., 2025, 23, 679
DOI: 10.1039/D4OB01554A

Recent advances in C–F bond activation of trifluoromethylated carbonyl compounds and derivatives

Xuanming Gong, Qin Zhou and Guobing Yan

Org. Biomol. Chem., 2022, 20, 5365
DOI: 10.1039/D2OB00795A

A Brønsted acid–base approach for the net monoselective C–F substitution of (trifluoromethyl)alkanes

Nicholas J. Coradi and Jeffrey S. Bandar

Chem. Sci., 2026, 17, 9644
DOI: 10.1039/D6SC01042C

Quantifying flattening distortion on the thermodynamics and kinetics of electron transfers of Cu(i) photoredox catalysts

Christian Sandoval-Pauker, Gabriela Molina-Aguirre, Dino Villagrán and Balazs Pinter

Inorg. Chem. Front., 2024, 11, 4019
DOI: 10.1039/D4QI00613E

Visible-light-induced transition-metal-free defluorosilylation of α-trifluoromethylalkenes via hydrogen atom transfer of silanes

Wengang Xu, Congjian Xia, Qi Shao, Qiao Zhang, Mingrui Liu, Hongwei Zhang and Mingbo Wu

Org. Chem. Front., 2022, 9, 4949
DOI: 10.1039/D2QO00894G

Metallaphotoredox-enabled enantioselective aryldifluoromethyl-alkynylation of alkenes via C(sp3)–F bond activation

Jialin Huang, Liying Fu, Xiaofei Zhao, Xingda Zhao, Zhanyong Tang, Xiaoqiang Ma and Depeng Zhao

Org. Chem. Front., 2025, 12, 3965
DOI: 10.1039/D5QO00370A

A general photocatalytic hydrodefluorination and defluoroalkylation of electronically-variable ArCF3 by changing commercially-available arenethiolates

Yuanyang Jiang, Chenxiu Han, Zipeng Guo, Zhenyang Dai, Guangchao Liang, Shuo Guo, Nathaniel K. Szymczak and Pingping Tang

Green Chem., 2024, 26, 4518
DOI: 10.1039/D3GC05041F

Light-induced aryldifluoromethyl-sulfonylation/thioetherification of alkenes using arenethiolates as a photoreductant and sulfur source

Jiayu Li, Zipeng Guo, Xiaofeng Zhang, Xiaoli Meng, Zhenyang Dai, Meiyun Gao, Shuo Guo and Pingping Tang

Green Chem., 2023, 25, 9292
DOI: 10.1039/D3GC03471B

Catalyst-free defluorinative alkylation of trifluoromethyls

Yan Huang, Yuan-Cui Wan, Yu Shao, Le-Wu Zhan, Bin-Dong Li and Jing Hou

Green Chem., 2023, 25, 8280
DOI: 10.1039/D3GC02547K

Chromium-catalyzed allylic defluorinative acylation of trifluoromethyl-substituted alkenes with acyl oxime esters

Hongzhang Shi, Haiyan Dong and Chuan Wang

Org. Chem. Front., 2023, 10, 5843
DOI: 10.1039/D3QO01331F

Organo-photoredox catalyzed gem-difluoroallylation of ketone-derived dihydroquinazolinones via C(sp3)–C bond and C(sp3)–F bond cleavage

Yue Zhang, Tianshuai Zhu, Yuqian Lin, Xian Wei, Xinyu Xie, Ruofan Lin, Zhijie Zhang, Weiwei Fang, Jing-Jing Zhang, Yue Zhang, Meng-Yang Hu, Lingchao Cai and Zhen Chen

Org. Biomol. Chem., 2024, 22, 5561
DOI: 10.1039/D4OB00671B

Modular synthesis of α-arylated carboxylic acids, esters and amides via photocatalyzed triple C–F bond cleavage of methyltrifluorides

Sifan Li, Paul W. Davies and Wei Shu

Chem. Sci., 2022, 13, 6636
DOI: 10.1039/D2SC01905A

Transition metal-free photochemical C–F activation for the preparation of difluorinated-oxindole derivatives

Bianca Matsuo, Jadab Majhi, Albert Granados, Mohammed Sharique, Robert T. Martin, Osvaldo Gutierrez and Gary A. Molander

Chem. Sci., 2023, 14, 2379
DOI: 10.1039/D2SC06179A

Electrosynthetic C–F bond cleavage

Johannes L. Röckl, Emma L. Robertson and Helena Lundberg

Org. Biomol. Chem., 2022, 20, 6707
DOI: 10.1039/D2OB01080A

Tripleipso-defluoroetherification of (trifluoromethyl)alkenes with fluoroalkylated alcohols: access to fluoroalkylated orthoestersviaC(sp3)–F bond cleavage

Jia Nie, Huanfeng Jiang and Chuanle Zhu

Chem. Commun., 2023, 59, 8238
DOI: 10.1039/D3CC01760E

Nickel-catalysed chelation-assisted reductive defluorinative sulfenylation of trifluoropropionic acid derivatives

Yu-Qiu Guan, Jia-Fan Qiao and Yu-Feng Liang

Chem. Commun., 2024, 60, 2405
DOI: 10.1039/D3CC06041A

Solvent-free base-controlled addition reaction ofH-phosphonates andH-phosphine oxides to α-CF3styrenes: facile synthesis of β-CF3-substituted phosphonates and phosphine oxides

Qianding Zeng, Ying Liu, Jingjing He, Yupian Deng, Pai Zheng, Zhudi Sun and Song Cao

Org. Biomol. Chem., 2023, 21, 4982
DOI: 10.1039/D3OB00681F

Difluoroenol phosphinates as difluoroenolate surrogates: synthesis and applications in defluorination and deoxygenative coupling

Miki B. Kurosawa, Shuhei Shimoyama, Hiroki Tanaka and Junichiro Yamaguchi

Chem. Sci., 2025, 16, 13390
DOI: 10.1039/D5SC03915K

Stereoselective hydrodefluorination of CF3-substituted alkenes and gem-difluoroalkenes by H−

Dachang Bai, Xin Li, Fen Wu and Junbiao Chang

Org. Chem. Front., 2024, 11, 1388
DOI: 10.1039/D3QO01900D

Electrochemical nickel-catalysed defluoroalkylation ofgem-difluoroalkenes with alkyl halides

Yin Liu, Pengfei Li, Jun Tan, Guangsheng Kou, Dengke Ma and Youai Qiu

Green Chem., 2023, 25, 7952
DOI: 10.1039/D3GC02814C

Two-step synthesis of vicinal trifluoromethyl primary amines from α-(trifluoromethyl)styrenes and phthalimide

Ying Liu, Jiaqi Huang, Zhudi Sun, Yupian Deng, Yuhao Qian, Qingchun Huang and Song Cao

Org. Biomol. Chem., 2024, 22, 4641
DOI: 10.1039/D4OB00567H

Cu-catalyzed cascade difluoroalkylation/5-endocyclization/β-fluorine cleavage of ynones

Jingwen Su, Wenbin Guo, Yi Liu, Lichun Kong, Hanliang Zheng and Gangguo Zhu

Chem. Commun., 2023, 59, 1821
DOI: 10.1039/D2CC06068J

Recent advances in visible-light-induced defluorinative functionalization of α-trifluoromethyl arylalkenes

Yanyan He, Leiyang Lv, Zhenhua Jia and Teck-Peng Loh

Org. Chem. Front., 2026, 13, 2178
DOI: 10.1039/D5QO01732G

Defluorinative Alkylboration of Alkenes Enabled by Dual Photoredox and Copper Catalysis

Yanmin Fan, Zhonghou Huang, Yi Lu, Shengqing Zhu and Lingling Chu

Angewandte Chemie, 2024, 136
DOI: 10.1002/ange.202315974

Application of the Spin-Center Shift in Organic Synthesis

Feng-Lian Zhang, Bin Li, K. N. Houk and Yi-Feng Wang

JACS Au, 2022, 2, 1032
DOI: 10.1021/jacsau.2c00051

Chemodivergent defluorinative alkylation and hydroalkylation of α-trifluoromethyl alkenes via Eosin Y catalysis and EDA photochemistry

Tianshuai Zhu, Xinyu Xie, Yue Zhang, Hua-Wei Liu, Jing-Jing Zhang, Lijun Tang, Weiwei Fang and Zhen Chen

Sci. China Chem., 2026, 69, 863
DOI: 10.1007/s11426-025-2831-2

Site-Selective Defluorinative Functionalization of Unactivated Alkenes Enabled by Cobalt/Photoredox Relay Catalysis

Shuaikang Ren, Guangying Huang, Yuyang Bai, Shengqing Zhu and Lingling Chu

ACS Catal., 2026, 16, 636
DOI: 10.1021/acscatal.5c07136

Defluorinative Multicomponent Cascade Reaction of Trifluoromethylarenes via Photoexcited Palladium Catalysis

Zhibin Li, Lei Bao, Kaihang Wei, Beibei Zhan, Ping Lu and Xiaheng Zhang

JACS Au, 2024, 4, 4223
DOI: 10.1021/jacsau.4c00899

Trifluoromethyl Group (CF3) Induced Regioselective Larock Indole Synthesis from Unsymmetric β-CF3-1,3-enynes

Yan-Hua Qiu, Pei-Yan Ma, Wen-Hao Shao, Chang-Qi Huang, Yongshun Wen, Zi-Ying Huang, Wenjun Luo, Lipeng Long, Xiangjun Peng and Daohong Yu

Org. Lett., 2025, 27, 3217
DOI: 10.1021/acs.orglett.5c00501

Synthesis of Fluorinated Compounds by Nickel-Catalyzed Defluorinative Cross-Coupling Reactions

Kuai Wang and Wangqing Kong

ACS Catal., 2023, 13, 12238
DOI: 10.1021/acscatal.3c02993

Photoredox-Catalyzed Defluorinative [4 + 2] Cycloaddition of α-Fluoro-β-keto Esters and Alkynes by Single Photosensitizer

Rui-Xue Liu, Xiu-Long Yang, Hao-Yuan Li, Jincan Zhao, Yi-Fan Song, Qing-Yuan Meng and Xiaoying Niu

Org. Lett., 2026, 28, 242
DOI: 10.1021/acs.orglett.5c04612

Decatungstate-Catalyzed Hydrosilylation of α-Trifluoromethylalkenes for Construction of α-Trifluoromethyl-β-silanes

Rui Xiao, Yutong Lang, Ziqiang Cheng, Liejin Zhou, Zhong-Yan Cao, Zheliang Yuan and Yanan Wang

Org. Lett., 2025, 27, 4439
DOI: 10.1021/acs.orglett.5c00796

Aryl Carboxylic Acids as Structure-Tunable HAT Agents for Photochemical Site-Selective C(sp3)–H gem-Difluoroallylation of Amides

Yujie Shan, Fang-Qi Gao, Chunhua Xu, Hua-Wei Liu, Lijun Tang, Jing-Jing Zhang, Weifan Wang, Zupeng Chen and Zhen Chen

Org. Lett., 2025, 27, 12223
DOI: 10.1021/acs.orglett.5c03502

Organophotoredox-catalyzed ring-opening gem-difluoroallylation of nonstrained cycloalkanols

Xiaochuang Wang, Yi Li, Jun Zhang and Xuesong Wu

Molecular Catalysis, 2022, 533, 112788
DOI: 10.1016/j.mcat.2022.112788

Transition-Metal-Free Late-Stage Decarboxylative gem-Difluoroallylation of Primary Alkyl Acids

Xian Wei, Yue Zhang, Ruofan Lin, Qi Zhu, Xinyu Xie, Yumeng Zhang, Weiwei Fang and Zhen Chen

J. Org. Chem., 2024, 89, 15234
DOI: 10.1021/acs.joc.4c02046

Modular Synthesis of α-Aryl Acrylamido Carboxylic Acids by Triple C–F Bond Cleavage of (Trifluoromethyl)alkenes with Unprotected Amino Acids

Yuqi Li, Rongbin Peng and Chuanle Zhu

Org. Lett., 2024, 26, 8295
DOI: 10.1021/acs.orglett.4c02988

New Opportunities to Access Fluorinated Molecules Using Organophotoredox Catalysis via C(sp3)–F Bond Cleavage

Sourav Roy and Tatiana Besset

JACS Au, 2025, 5, 466
DOI: 10.1021/jacsau.4c01158

Visible-Light-Induced Defluorinative α-C(sp3)–H Alkylation for the Synthesis of gem-Difluoroallylated α-Trifluoromethylamines

Bingran Chen, Qinlin Chen, Yang Liu, Jinxiu Chen, Xi Zhou, Haifeng Wang, Qiongjiao Yan, Wei Wang, Zeyu Cai and Fen-Er Chen

Org. Lett., 2023, 25, 9124
DOI: 10.1021/acs.orglett.3c03523

Cobalt‐Catalyzed Allylic Defluorinative Cross‐Electrophile Coupling between 1,1‐Difluoroalkyl Halides and α‐Trifluoromethyl Styrenes

Haiyan Dong, Zhiyang Lin and Chuan Wang

Adv Synth Catal, 2023, 365, 1165
DOI: 10.1002/adsc.202300171

Recent Developments in Defluorinative Functionalization of β‐Trifluoromethyl Enones

Danhua Ge, Shuang Liu, Yu‐Shun Jiang, Xiao Wang, Xue‐Ying Huang, Mengtao Ma, Xianxian Mao and Xue‐Qiang Chu

Adv Synth Catal, 2026, 368
DOI: 10.1002/adsc.70556

Iron-Catalyzed Allylic Defluorinative Ketone Olefin Coupling

Chang Zhang, Lin Wang, Hongzhang Shi, Zhiyang Lin and Chuan Wang

Org. Lett., 2022, 24, 3211
DOI: 10.1021/acs.orglett.2c00979

Catalytic C(sp3)–F Bond Activation at Low-Valent Germanium and Tin Redox Platforms

Zhuchunguang Liu, Ru-De Lin, Baihan Ma, Bo Xiao, Xiao Xiao, Xiaoming Zeng and Zhaowen Dong

J. Am. Chem. Soc., 2026, 148, 11176
DOI: 10.1021/jacs.5c22945

Defluorinative Alkylboration of Alkenes Enabled by Dual Photoredox and Copper Catalysis

Yanmin Fan, Zhonghou Huang, Yi Lu, Shengqing Zhu and Lingling Chu

Angew Chem Int Ed, 2024, 63
DOI: 10.1002/anie.202315974

Sequential C−F Bond Transformation of the Difluoromethylene Unit in Perfluoroalkyl Groups: A Combination of Fine‐Tuned Phenothiazine Photoredox Catalyst and Lewis Acid

Naoki Sugihara, Yoshihiro Nishimoto, Yasuko Osakada, Mamoru Fujitsuka, Manabu Abe and Makoto Yasuda

Angew Chem Int Ed, 2024, 63
DOI: 10.1002/anie.202401117

Halogen‐Atom Transfer Enabled Catalytic Enantioselective Coupling to Chiral Trifluoromethylated Alkynes via Dual Nickel and Photocatalysis

Shanya Lu, Zihao Hu, Dong Wang and Tao XU

Angew Chem Int Ed, 2024, 63
DOI: 10.1002/anie.202406064

Fluorinated Dihydropentalene‐1,4‐Dione: A Strong Electron‐Accepting Unit with Organic Semiconductor Characteristics

Soichi Yokoyama and Yutaka Ie

Chemistry A European J, 2023, 29
DOI: 10.1002/chem.202203873

Controlled Defluorinative Carboxylation Cascade of Sterically Hindered CF3-Alkenes with Formate Salt via Photocatalysis

Runze Zhai, Haiping Yu, Jiexiang Ma, Yaxin Sun and Peng Yang

Org. Lett., 2025, 27, 2492
DOI: 10.1021/acs.orglett.5c00476

Alkene 1,1-difunctionalizations via organometallic-radical relay

Dong Wu, Weiyu Kong, Yang Bao, Dengyang Zhao, Yuqiang Li and Guoyin Yin

Nat Catal, 2023, 6, 1030
DOI: 10.1038/s41929-023-01032-0

Iron-Catalyzed Reductive Ring Opening/gem-Difluoroallylation of Cyclopropyl Ketones

Bing Yuan, Chang Zhang, Haiyan Dong and Chuan Wang

Org. Lett., 2023, 25, 1883
DOI: 10.1021/acs.orglett.3c00398

Magnesium‐Mediated Reductive Defluorinative Cross‐Electrophile Coupling of α‐Trifluoromethyl Styrenes with CO2 and Acyl Imidazoles

Jianjun Hao, Lu Ren, Jingwen Tan, Yulin Peng, Linhai Jing and Pan Han

Adv Synth Catal, 2025, 367
DOI: 10.1002/adsc.202401594

Cross-coupling of trifluoromethylarenes with alkynes C(sp)-H bonds and azoles C(sp2)-H bonds via photoredox/copper dual catalysis

Jialin Huang, Liying Fu, Zhanyong Tang, Xiaoqiang Ma, Xingda Zhao and Depeng Zhao

Chinese Chemical Letters, 2025, 36, 110505
DOI: 10.1016/j.cclet.2024.110505

Mild [3 + 3] Annulation of (Trifluoromethyl)alkenes with Thioureas Enabled by Chemoselective Defluorinative Amination: Synthesis of 6-Fluoro-3,4-dihydropyrimidine-2(1H)-thiones

Rongbin Peng and Chuanle Zhu

J. Org. Chem., 2025, 90, 1538
DOI: 10.1021/acs.joc.4c02479

Synthetic Advantages of Defluorinative C−F Bond Functionalization

Leidy V. Hooker and Jeffrey S. Bandar

Angew Chem Int Ed, 2023, 62
DOI: 10.1002/anie.202308880

(E)-Selective Defluorinative Diphenothiazination of Trifluoromethyl Styrenes

Yun Yang, Ben Ebel, Iris M. Oppel and Frederic W. Patureau

Synthesis, 2026, 58, 632
DOI: 10.1055/a-2735-9268

Recent Advances in the Electrochemical Defluorinative Transformations of C—F Bonds

Qinhui Wan, Rui‐Xue Liu, Zhongyi Zhang, Xia‐Die Wu, Zhong‐Wei Hou and Lei Wang

Chin. J. Chem., 2024, 42, 1913
DOI: 10.1002/cjoc.202400058

General Defluoroalkylation of Trifluoromethylarenes with Both Electron-Donating and -Withdrawing Alkenes

Mengqi Zhu, Qiao-Lin Wang, Huawen Huang, Guojiang Mao and Guo-Jun Deng

J. Org. Chem., 2024, 89, 12591
DOI: 10.1021/acs.joc.4c01531

Palladium‐Catalyzed Ring‐Opening/Defluorinative Annulation of gem‐Difluorocyclopropanes With β‐Keto Sulfones: Synthesis of Multi‐Substituted Furans

Wanqing Lu, Ge Liang, Juanjuan Wu and Leiyang Lv

Chemistry A European J, 2026, 32
DOI: 10.1002/chem.70879

Photo‐/Electrochemically Radical Cation‐/Anion‐Mediated Defluorinative Functionalization of Organofluorides

Chaozhihui Cheng, Yong‐Fei Huang, Li‐Jie Wang, Mu‐Jia Luo and Qiang Xiao

Adv Synth Catal, 2025, 367
DOI: 10.1002/adsc.70102

Photocatalyzed C–F Bond Heteroarylation of Trifluoromethylarenes with Heteroarenes: Two Roles of Bu3SnI as Fluoride Ion Scavenger and Activator for Photocatalyst

Naoki Sugihara, Masayuki Abe, Yoshihiro Nishimoto and Makoto Yasuda

Synthesis, 2024, 56, 3297
DOI: 10.1055/a-2235-1380

Hybrid Palladium-Catalyzed Intramolecular Carboamination of Conjugated Dienes: Synthesis of Functionalized Pyrrolidines via Selective Trifluoromethylarene Defluorination

Feijie Zhang, Guocong Zhang, Qixin Zhou, Tiancen Bian, Liejin Zhou and Zuxiao Zhang

J. Org. Chem., 2024, 89, 7790
DOI: 10.1021/acs.joc.4c00447

Elucidating the Key Factors in Hydroamination and Defluoroamination Competitions: A DFT Analysis of Reaction between α‐(Trifluoromethyl)styrene and 2‐Pyridones

Haoran Xu, Yuchen Zhang and Xiao‐Song Xue

Eur J Org Chem, 2024, 27
DOI: 10.1002/ejoc.202400125

Defluorinative Fluoro‐Aza‐Nazarov Cyclization

Chi Zhang, Geng Huang, Tianxiang Gao, Yuting Liu, Wenjing Jia, Chuan Zhu, Kai Guo and Chao Feng

Angew Chem Int Ed, 2025, 64
DOI: 10.1002/anie.202518782

gem-Difluoroallylation of Unactivated Alkanes Enabled by Core-Fluorinated Acridine d-HAT Catalysis

Chunhua Xu, Zhijie Zhang, Yuan Kong, Ziyi Wu, Jing-Jing Zhang, Lijun Tang and Zhen Chen

Org. Lett., 2026, 28, 6715
DOI: 10.1021/acs.orglett.6c01553

Photochemical and Electrochemical Strategies for Hydrodefluorination of Fluorinated Organic Compounds

Guobing Yan

Chemistry A European J, 2022, 28
DOI: 10.1002/chem.202200231

Visible-Light-Induced Synergistic W/Cr Catalyzed gem-Difluoroallylation of Unactivated Alkanes

Zhijie Zhang, Yue Zhang, Xinyu Xie, Hua-Wei Liu, Tianshuai Zhu, Jing-Jing Zhang, Meng-Yang Hu and Zhen Chen

Org. Lett., 2025, 27, 2016
DOI: 10.1021/acs.orglett.5c00464

Nickel-Catalyzed Cross-Electrophile Ring Opening/gem-Difluoroallylation of Aziridines

Wei Tang and Pei Fan

Org. Lett., 2023, 25, 5756
DOI: 10.1021/acs.orglett.3c01973

Halogen‐Atom Transfer Enabled Catalytic Enantioselective Coupling to Chiral Trifluoromethylated Alkynes via Dual Nickel and Photocatalysis

Shanya Lu, Zihao Hu, Dong Wang and Tao XU

Angewandte Chemie, 2024, 136
DOI: 10.1002/ange.202406064

Defluorinative Fluoro‐Aza‐Nazarov Cyclization

Chi Zhang, Geng Huang, Tianxiang Gao, Yuting Liu, Wenjing Jia, Chuan Zhu, Kai Guo and Chao Feng

Angewandte Chemie, 2025, 137
DOI: 10.1002/ange.202518782

Photocatalytic C(sp3)‐H gem‐Difluoroallylation and Alkylation with Alkenes via a Base‐Assisted Formal 1,2‐Hydrogen Atom Transfer of Amidyl Radicals

Meifang Tang, Bingbing Feng, Yanyang Bao, Zhongtian Xu, Chao Huang, Hanliang Zheng, Gangguo Zhu, Yanan Wang and Zheliang Yuan

Chin. J. Chem., 2024, 42, 2203
DOI: 10.1002/cjoc.202400122

Recent Advance in Defluorinative Transformations of α‐Trifluoromethyl Carbene Intermediates

Kewei Chen, Abdulla Yusuf and Xinfang Xu

ChemCatChem, 2026, 18
DOI: 10.1002/cctc.202501604

Synthesis of substituted (trifluoromethyl)alkenes: (Trifluoromethyl)alkylidenation of thioketones via CF3-thiiranes

Kohei Fuchibe, Tomoya Matsunobu and Junji Ichikawa

Journal of Fluorine Chemistry, 2024, 275, 110273
DOI: 10.1016/j.jfluchem.2024.110273

Cooperative Trifluoromethyl Group and Catalyst‐Enabled Regioselective 3,4‐Functionalization of Unsymmetric β‐CF3‐1,3‐enynes via C–H Bond Activation

Yongshun Wen, Yun Liao, Mei Xiao, Jin Zhu, Li‐Juan Tang, Yingtong Zong, Wenjun Luo, Zhengwang Chen and Daohong Yu

Chin. J. Chem., 2025, 43, 2512
DOI: 10.1002/cjoc.70152

Picking Two out of Three: Defluorinative Annulation of Trifluoromethyl Alkenes for the Synthesis of Monofluorinated Carbo‐ and Heterocycles

Jiahao Ling and Lei Zhou

The Chemical Record, 2024, 24
DOI: 10.1002/tcr.202300332

Solvent-Controllable C–F Bond Activation for Masked Formylation of α-Trifluoromethyl Alkenes via Organo-Photoredox Catalysis

Xian Wei, Yue Zhang, Jing-Jing Zhang, Weiwei Fang and Zhen Chen

J. Org. Chem., 2024, 89, 624
DOI: 10.1021/acs.joc.3c02385

Sequential C−F Bond Transformation of the Difluoromethylene Unit in Perfluoroalkyl Groups: A Combination of Fine‐Tuned Phenothiazine Photoredox Catalyst and Lewis Acid

Naoki Sugihara, Yoshihiro Nishimoto, Yasuko Osakada, Mamoru Fujitsuka, Manabu Abe and Makoto Yasuda

Angewandte Chemie, 2024, 136
DOI: 10.1002/ange.202401117

Organo-Photoredox Catalyzed gem-Difluoroallylation of Glycine and Glycine Residue in Peptides

Ruofan Lin, Yujie Shan, Yan Li, Xian Wei, Yue Zhang, Yuqian Lin, Yiman Gao, Weiwei Fang, Jing-Jing Zhang, Ting Wu, Lingchao Cai and Zhen Chen

J. Org. Chem., 2024, 89, 4056
DOI: 10.1021/acs.joc.3c02923

Selective C–F Bond Etherification of Trifluoromethylalkenes with Phenols

Qingqiang Tian, Boqun Pei, Chuxia Wang, Chiying Zhang and Yahui Li

J. Org. Chem., 2022, 87, 10908
DOI: 10.1021/acs.joc.2c01197

Divergent defluorocarboxylation of α-CF3 alkenes with formate via photocatalyzed selective mono- or triple C-F bond cleavage

Xing-Yu Wang, Pei Xu, Wen-Wen Liu, Hao-Qiang Jiang, Song-Lei Zhu, Dong Guo and Xu Zhu

Sci. China Chem., 2024, 67, 368
DOI: 10.1007/s11426-023-1731-x

Visible-Light-Mediated Multicomponent Synthesis of Azido-Substituted gem-Difluoroalkenes

Jiabin Shen, Du Hu, Yi Chen, Hao Xu, Donghao Wang, Kai Ge, Chao Shen and Min Wang

J. Org. Chem., 2026, 91, 5201
DOI: 10.1021/acs.joc.6c00207

Defluorinative Esterification and 1,3-Dietherification of (Trifluoromethyl)alkenes with Alcohols: Controlled Synthesis of α-Arylacrylates and 1,3-Diethers

Hengyuan Li and Chuanle Zhu

J. Org. Chem., 2023, 88, 4134
DOI: 10.1021/acs.joc.2c02568

Synthetic Advantages of Defluorinative C−F Bond Functionalization

Leidy V. Hooker and Jeffrey S. Bandar

Angewandte Chemie, 2023, 135
DOI: 10.1002/ange.202308880

Cascade C–H Activation and Defluorinative Annulation of 2-Arylbenzimidazoles with α-Trifluoromethyl-α-diazoketones: Modular Assembly of 6-Fluorobenzimidazo[2,1-a]isoquinolines

Zhongkang Dong, Hengzhi Zhang, Baiquan Wang and Bin Li

Org. Lett., 2023, 25, 4770
DOI: 10.1021/acs.orglett.3c01296