Varun Sridhar, Erdost Yildiz, Andrés Rodríguez‐Camargo, Xianglong Lyu, Liang Yao, Paul Wrede, Amirreza Aghakhani, Birgul M. Akolpoglu, Filip Podjaski, Bettina V. Lotsch and Metin Sitti

Advanced Materials, 2023, 35
DOI: 10.1002/adma.202301126

Immune checkpoint inhibition combined with targeted therapy using a novel virus-like drug conjugate induces complete responses in a murine model of local and distant tumors

Ruben V. Huis in ‘t Veld, Sen Ma, Rhonda C. Kines, Anneli Savinainen, Cadmus Rich, Ferry Ossendorp and Martine J. Jager

Cancer Immunol Immunother, 2023, 72, 2405
DOI: 10.1007/s00262-023-03425-3

Heptamethine Cyanine-Loaded Nanomaterials for Cancer Immuno-Photothermal/Photodynamic Therapy: A Review

Cátia G. Alves, Rita Lima-Sousa, Bruna L. Melo, André F. Moreira, Ilídio J. Correia and Duarte de Melo-Diogo

Pharmaceutics, 2022, 14, 1015
DOI: 10.3390/pharmaceutics14051015

Covalent organic framework nanomedicines: Biocompatibility for advanced nanocarriers and cancer theranostics applications

Nem Singh, Jungryun Kim, Jaewon Kim, Kyungwoo Lee, Zehra Zunbul, Injun Lee, Eunji Kim, Sung-Gil Chi and Jong Seung Kim

Bioactive Materials, 2023, 21, 358
DOI: 10.1016/j.bioactmat.2022.08.016

Advances and applications of nanoparticles in cancer therapy

Xianzhou Huang, Tao He, Xiuqi Liang, Zhongzheng Xiang, Chao Liu, Shiyao Zhou, Rui Luo, Liping Bai, Xiaorong Kou, Xinchao Li, Rui Wu, Xinyu Gou, Xinyue Wu, Dongxue Huang, Wangxian Fu, Yingjie Li, Ruhan Chen, Ningyue Xu, Yixi Wang, Hao Le, Tao Chen, Yangsong Xu, Yuting Tang and Changyang Gong

MedComm – Oncology, 2024, 3
DOI: 10.1002/mog2.67

Characteristic Synthesis of a Covalent Organic Framework and Its Application in Multifunctional Tumor Therapy

Shengnan Zhou, Tao Meng, Danyou Hu, Yuheng Zhu, Chenguang Huang, Mengmeng Song, Shan Gao and Guiyang Zhang

ACS Appl. Bio Mater., 2022, 5, 59
DOI: 10.1021/acsabm.1c01039

Research Progress on the Synthesis of Covalent Organic Frameworks and Their Applications in Tumor Therapy

Tao Wang, Lu Zhao, Kewei Wang, Yunfeng Bai and Feng Feng

Acta Chimica Sinica, 2021, 79, 600
DOI: 10.6023/A20120578

Recent advances in porous nanomaterials-based drug delivery systems for cancer immunotherapy

Su-Ran Li, Fang-Yi Huo, Han-Qi Wang, Jing Wang, Chun Xu, Bing Liu and Lin-Lin Bu

J Nanobiotechnol, 2022, 20
DOI: 10.1186/s12951-022-01489-4

Targeting tumor microenvironment with photodynamic nanomedicine

Suraj Kumar Modi, Pragyan Mohapatra, Priya Bhatt, Aishleen Singh, Avanish Singh Parmar, Aniruddha Roy, Vibhuti Joshi and Manu Smriti Singh

Medicinal Research Reviews, 2025, 45, 66
DOI: 10.1002/med.22072

Combining Photodynamic Therapy with Immunostimulatory Nanoparticles Elicits Effective Anti-Tumor Immune Responses in Preclinical Murine Models

Ruben Victor Huis in ‘t Veld, Candido G. Da Silva, Martine J. Jager, Luis J. Cruz and Ferry Ossendorp

Pharmaceutics, 2021, 13, 1470
DOI: 10.3390/pharmaceutics13091470

Hyperthermia Targeting the Tumor Microenvironment Facilitates Immune Checkpoint Inhibitors

Zihui Li, Jie Deng, Jianhai Sun and Yanling Ma

Front. Immunol., 2020, 11
DOI: 10.3389/fimmu.2020.595207

Covalent Organic Framework Controls the Aggregation of Metal Porphyrins for Enhanced Photocatalytic H2 Evolution

Yuesheng Han, Yucheng Jin, Gengxiang Yang, Xiaolin Ma, Xinxin Wang, Dongdong Qi, Tianyu Wang and Jianzhuang Jiang

Chemistry An Asian Journal, 2025, 20
DOI: 10.1002/asia.202401342

Potential of Covalent Organic Framework in Pharmacy and Biomedicine: Influence of Structure on Properties and Applications

Julia Kolodziejczyk and Marta E. Plonska‐Brzezinska

ChemMedChem, 2026, 21
DOI: 10.1002/cmdc.202501039

Construction of Nanoscale Covalent Organic Frameworks via Photocatalysis‐Involved Cascade Reactions for Tumor‐Selective Treatment

Qun Guan, Le‐Le Zhou and Yu‐Bin Dong

Advanced Therapeutics, 2022, 5
DOI: 10.1002/adtp.202100177

NIR-Responsive Carbon Dots Functionalized with AS1411 Aptamer: A Dual-Mode Approach to Enhanced Photothermal and Photodynamic Therapy

Kanchan Negi, Sushmita Patra, Ashok Kumar, Sujit Kumar Bhutia and Sumanta Kumar Sahu

ACS Appl. Bio Mater., 2025, 8, 6305
DOI: 10.1021/acsabm.5c00775

Near-infrared photodynamic and photothermal co-therapy based on organic small molecular dyes

Shuang Guo, Dongyu Gu, Yi Yang, Jing Tian and Xiaoyuan Chen

J Nanobiotechnol, 2023, 21
DOI: 10.1186/s12951-023-02111-x

Photodynamic therapy combined with immunotherapy: Recent advances and future research directions

Marta Warszyńska, Paweł Repetowski and Janusz M. Dąbrowski

Coordination Chemistry Reviews, 2023, 495, 215350
DOI: 10.1016/j.ccr.2023.215350

Facile Preparation of a Thienoisoindigo-Based Nanoscale Covalent Organic Framework with Robust Photothermal Activity for Cancer Therapy

Rui Xia, Chaonan Li, Xiaodie Yuan, Qihang Wu, Bowen Jiang and Zhigang Xie

ACS Appl. Mater. Interfaces, 2022, 14, 19129
DOI: 10.1021/acsami.2c01701

Innovative applications and synergistic strategies for covalent organic frameworks in multimodal phototherapy

Huiming Chen, Jinpei Mei, Jie Chen, Taju Wu, Tao Ma, Yutian Su, Ninglin Zhou and Baohong Sun

Acta Biomaterialia, 2025, 207, 515
DOI: 10.1016/j.actbio.2025.10.013

Covalent organic frameworks: Prospects and potential in tumor diagnosis and therapy

Wenxiang Zhang, Lijuan Yang, Junjie Zou, Dazhuang Xu, Gang Liu and Zhixiang Lu

Chemical Engineering Journal, 2025, 519, 165302
DOI: 10.1016/j.cej.2025.165302

Covalent Organic Framework-Based Nanocomposite for Synergetic Photo-, Chemodynamic-, and Immunotherapies

Sainan Liu, Ying Zhou, Chunling Hu, Lihan Cai and Maolin Pang

ACS Appl. Mater. Interfaces, 2020, 12, 43456
DOI: 10.1021/acsami.0c12824

GSH-responsive polymeric micelles-based augmented photoimmunotherapy synergized with PD-1 blockade for eliciting robust antitumor immunity against colon tumor

Chenlu Huang, Xinyu Yang, Huidong Li, Li Zhang, Qing Guo, Qingyu Yu, Hai Wang, Linhua Zhang and Dunwan Zhu

J Nanobiotechnol, 2024, 22
DOI: 10.1186/s12951-024-02813-w

Nanoparticle-Based Drug Delivery Systems Targeting Tumor Microenvironment for Cancer Immunotherapy Resistance: Current Advances and Applications

Peijie Wu, Jun Han, Yanju Gong, Chao Liu, Han Yu and Na Xie

Pharmaceutics, 2022, 14, 1990
DOI: 10.3390/pharmaceutics14101990

Dual-Functional PLGA Nanoparticles Co-Loaded with Indocyanine Green and Resiquimod for Prostate Cancer Treatment

Wenfeng Lin, Chaoming Li, Naijin Xu, Masami Watanabe, Ruizhi Xue, Abai Xu, Motoo Araki, Ruifen Sun, Chunxiao Liu, Yasutomo Nasu and Peng Huang

IJN, 2021, Volume 16, 2775
DOI: 10.2147/IJN.S301552

Heparin modified photosensitizer-loaded liposomes for tumor treatment and alleviating metastasis in phototherapy

Dinglingge Cao, Huangjuan Li, Yuan Luo, Nianping Feng and Tianyuan Ci

International Journal of Biological Macromolecules, 2021, 168, 526
DOI: 10.1016/j.ijbiomac.2020.12.043

PLGA nanomedical consignation: A novel approach for the management of prostate cancer

Tenzin Sonam Dongsar, Tenzin Tsering Dongsar, Garima Gupta, Abdulrhman Alsayari, Shadma Wahab and Prashant Kesharwani

International Journal of Pharmaceutics, 2024, 652, 123808
DOI: 10.1016/j.ijpharm.2024.123808

Recent advances in supramolecular activatable phthalocyanine-based photosensitizers for anti-cancer therapy

Bing-De Zheng, Jing Ye, Xue-Qin Zhang, Na Zhang and Mei-Tian Xiao

Coordination Chemistry Reviews, 2021, 447, 214155
DOI: 10.1016/j.ccr.2021.214155

Current Challenges and Opportunities of Photodynamic Therapy against Cancer

Ruben V. Huis in ‘t Veld, Jeroen Heuts, Sen Ma, Luis J. Cruz, Ferry A. Ossendorp and Martine J. Jager

Pharmaceutics, 2023, 15, 330
DOI: 10.3390/pharmaceutics15020330

Covalent Organic Frameworks: Opportunities for Rational Materials Design in Cancer Therapy

Le‐Le Zhou, Qun Guan and Yu‐Bin Dong

Angewandte Chemie, 2024, 136
DOI: 10.1002/ange.202314763

Antitumor Effects of PD-1 Blockade Combined with Mild Hyperthermia in a Murine Osteosarcoma Model

Yuya Izubuchi, Naoi Hosoe, Takaaki Tanaka, Yumiko Watanabe, Tatsunobu Kobayashi, Hideaki Nakajima, Hiroyasu Kidoya and Akihiko Matsumine

Biomedicines, 2026, 14, 341
DOI: 10.3390/biomedicines14020341

Advances in covalent organic frameworks for cancer phototherapy

Nem Singh, Miae Won, Jusung An, Changyu Yoon, Dongeun Kim, Suk Joong Lee, Heemin Kang and Jong Seung Kim

Coordination Chemistry Reviews, 2024, 506, 215720
DOI: 10.1016/j.ccr.2024.215720

Copper sulfide engineered covalent organic frameworks for pH-responsive chemo/photothermal/chemodynamic synergistic therapy against cancer

Shuangling Wang, Yu Pang, Shuyang Hu, Jie Lv, Yulong Lin and Meng Li

Chemical Engineering Journal, 2023, 451, 138864
DOI: 10.1016/j.cej.2022.138864

Review on combination strategy of immune checkpoint blockade, photodynamic therapy and nanomedicine against solid tumor

Xin Li, Yu Zhen and Shanshan Li

Materials & Design, 2021, 209, 109958
DOI: 10.1016/j.matdes.2021.109958

Three-Dimensional Covalent Organic Frameworks with Cross-Linked Pores for Efficient Cancer Immunotherapy

Liang Zhang, Lei-Lei Yang, Shu-Cheng Wan, Qi-Chao Yang, Yao Xiao, Hexiang Deng and Zhi-Jun Sun

Nano Lett., 2021, 21, 7979
DOI: 10.1021/acs.nanolett.1c02050

Covalent Organic Framework–Titanium Oxide Nanocomposite for Enhanced Sonodynamic Therapy

Lihan Cai, Chunling Hu, Sainan Liu, Ying Zhou, Zhendong Liu and Maolin Pang

Bioconjugate Chem., 2021, 32, 661
DOI: 10.1021/acs.bioconjchem.1c00039

Recent advancements in synthesis and applications of covalent organic frameworks

Sapna Raghav, Jyoti Raghav, Ma'aruf Abdulmumin Muhammad, Madhur Babu Singh, Pallavi Jain and Dinesh Kumar

Applied Materials Today, 2025, 44, 102694
DOI: 10.1016/j.apmt.2025.102694

Phototherapy meets immunotherapy: a win–win strategy to fight against cancer

Jianhua Zou, Ling Li, Zhen Yang and Xiaoyuan Chen

Nanophotonics, 2021, 10, 3229
DOI: 10.1515/nanoph-2021-0209

Covalent Organic Frameworks as Nanocarriers for Improved Delivery of Chemotherapeutic Agents

Weiming Liu, Xinyu Ma, Shuayb Mohamed Kheyr, Anjie Dong and Jianhua Zhang

Materials, 2022, 15, 7215
DOI: 10.3390/ma15207215

Preparation of sulfonic acid functionalized covalent organic framework solid phase microextraction fibers and their application in the analysis of neurotransmitters in the mouse brain

Cheng YANG, Yanmei SHI, Tiantian PANG, Xiaobing LIU, Zhiyu ZHANG, Kai HU and Shusheng ZHANG

CJCSP, 2023, 41, 911
DOI: 10.3724/SP.J.1123.2023.03006

Covalent organic frameworks in cancer theranostics: advancing biomarker detection and tumor-targeted therapy

Sonia Iranpour, Amir Abrishami and Amir Sh. Saljooghi

Arch. Pharm. Res., 2025
DOI: 10.1007/s12272-025-01536-2

Donor-acceptor structured photothermal COFs for enhanced starvation therapy

Shaohua Song, Dandan Wang, Kai Zhao, Yuting Wu, Pei Zhang, Jinfeng Liu, Ge Yang, Peiwei Gong and Zhe Liu

Chemical Engineering Journal, 2022, 442, 135963
DOI: 10.1016/j.cej.2022.135963

Synergistic Antibacterial and Anti‐Inflammatory Effects of a Drug‐Loaded Self‐Standing Porphyrin‐COF Membrane for Efficient Skin Wound Healing

Luo‐Gang Ding, Song Wang, Bing‐Jian Yao, Fei Li, Yan‐An Li, Guo‐Yan Zhao and Yu‐Bin Dong

Adv Healthcare Materials, 2021, 10
DOI: 10.1002/adhm.202001821

Intelligent delivery system targeting PD-1/PD-L1 pathway for cancer immunotherapy

Ning Liu, Renshuai Zhang, Qiang Shi, Hongfei Jiang and Qihui Zhou

Bioorganic Chemistry, 2023, 136, 106550
DOI: 10.1016/j.bioorg.2023.106550

Covalent Organic Frameworks (COFs) as Advanced Carriers for Corrosion Prevention: Cutting‐Edge Advances and Promising Future Opportunities

Pallavi Singh and Pragnesh N. Dave

ChemNanoMat, 2025, 11
DOI: 10.1002/cnma.202400523

Nanomedicine-Mediated Immunotherapy for Cancer Treatment

Wei Hou, Wen Qi Song, Rui Xue Zhang, Maria V. Lomova, Alexandr V. Sadovnikov and Yu Jun Song

ACS Biomater. Sci. Eng., 2026, 12, 1968
DOI: 10.1021/acsbiomaterials.5c02061

A tumor-microenvironment-activated nanoplatform of modified SnFe2O4 nanozyme in scaffold for enhanced PTT/PDT tumor therapy

Yang Shuai

Heliyon, 2023, 9, e18019
DOI: 10.1016/j.heliyon.2023.e18019

Hyaluronic acid-modified doxorubicin-covalent organic framework nanoparticles triggered pyroptosis in combinations with immune checkpoint blockade for the treatment of breast cancer

Shengsheng Zhao, Binglong Bai, Bingzi Zhu, Yuekai Cui, Wenhai Deng, Zuoliang Xie, Shuaibin Wang, Xiang Wang, Yiwen Mao, Yongyong Lu, Yingpeng Huang, Tao You, Weijian Sun, Xian Shen and Xufeng Lu

International Journal of Biological Macromolecules, 2025, 310, 143265
DOI: 10.1016/j.ijbiomac.2025.143265

A Self-Assembly ICG Nanoparticle Potentiating Targeted Photothermal and Photodynamic Therapy in NSCLC

Xiaoyi Hu, Jiwei Li, Yulun Chen, Qiuyue Long, Yangyuyan Bai, Ran Li, Keqiang Wang, Mingzheng Jiang, Chaoyang Chen, Jingsong Mao, Yali Zheng and Zhancheng Gao

ACS Biomater. Sci. Eng., 2022, 8, 4535
DOI: 10.1021/acsbiomaterials.2c00620

Advances in Nanotechnology‐Driven Enhancement of Type I Photosensitizers for Tumor Photo‐Immunotherapy

Wen Ma, Peiye Wen, Zikang Chen, M. Mustafa Cetin, Zhuting Fang and Zhen Yang

Small, 2025, 21
DOI: 10.1002/smll.202510047

Atomistic insight into 2D COFs as antiviral agents against SARS-CoV-2

Ahmad Miri Jahromi, Aida Solhjoo, Mehdi Ghasemi, Mohammad Khedri, Reza Maleki and Lobat Tayebi

Materials Chemistry and Physics, 2022, 276, 125382
DOI: 10.1016/j.matchemphys.2021.125382

Progress of Photodynamic and RNAi Combination Therapy in Cancer Treatment

Kun Li, Yuquan Zhang, Abid Hussain, Yuhua Weng and Yuanyu Huang

ACS Biomater. Sci. Eng., 2021, 7, 4420
DOI: 10.1021/acsbiomaterials.1c00765

Covalent organic framework-based nanoplatforms with tunable mechanical properties for drug delivery and cancer therapy

Liefeng Hu and Yonggang Lv

Mechanobiology in Medicine, 2023, 1, 100024
DOI: 10.1016/j.mbm.2023.100024

Covalent Organic Frameworks: Opportunities for Rational Materials Design in Cancer Therapy

Le‐Le Zhou, Qun Guan and Yu‐Bin Dong

Angew Chem Int Ed, 2024, 63
DOI: 10.1002/anie.202314763

Recent advances in nanoparticles-based photothermal therapy synergizing with immune checkpoint blockade therapy

Xinlun Dai, Xin Li, Yahui Liu and Fei Yan

Materials & Design, 2022, 217, 110656
DOI: 10.1016/j.matdes.2022.110656

Copper-doped COF triggered bioorthogonal synergistic cancer therapy through apoptosis and cuproptosis

Junhe Ou, Liangmei Yang, Luwen Zhang, Tingyan Jiang, Jiarui Qiao and Maolin Pang

Bioorganic Chemistry, 2026, 174, 109720
DOI: 10.1016/j.bioorg.2026.109720