FermentedAngelica sinensisactivates Nrf2 signaling and modulates the gut microbiota composition and metabolism to attenuated-gal induced liver aging

Xuerui Lu, Junxiang Li, Yingchun Ma, Israr Khan, Yun Yang, Yuxi Li, YaFei Wang, GuanLan Liu, Zhiming Zhang, Pingrong Yang and Chunjiang Zhang

Food Funct., 2023, 14, 215
DOI: 10.1039/D2FO01637K

Progress in the discovery and development of anticancer agents from marine cyanobacteria

Hendrik Luesch, Emma K. Ellis, Qi-Yin Chen and Ranjala Ratnayake

Nat. Prod. Rep., 2025, 42, 208
DOI: 10.1039/D4NP00019F

Bioactives and their metabolites from Tetrastigma hemsleyanum leaves ameliorate DSS-induced colitis via protecting the intestinal barrier, mitigating oxidative stress and regulating the gut microbiota

Tong Wu, Xiaoya Wang, Hua Xiong, Zeyuan Deng, Xin Peng, Lihua Xiao, Li Jiang and Yong Sun

Food Funct., 2021, 12, 11760
DOI: 10.1039/D1FO02588K

In vitro and in silico hybrid approach to unveil triterpenoids from Helicteres hirsuta leaves as potential compounds for inhibiting Nrf2

Minh Hien Nguyen, Nguyen Thien Han Le, Bui Quoc Huy Nguyen, Mai Thanh Thi Nguyen, Truong Nhat Van Do, Tho Huu Le, Vu Thanh Nguyen and Chia-Hung Yen

RSC Adv., 2025, 15, 1915
DOI: 10.1039/D4RA07646J

Self-assembled nanoplatform-mediated co-delivery of brusatol to sensitize sorafenib for hepatocellular carcinoma treatment

Fengrui Liu, Senlin Li, Chengcheng Huang, Zhenfei Bi, Xiao Xiang, Shuqi Zhang, Ruihao Yang and Lu Zheng

RSC Adv., 2025, 15, 11675
DOI: 10.1039/D5RA00108K

Stretch Causes Cell Stress and the Downregulation of Nrf2 in Primary Amnion Cells

Justin Gary Padron, Nainoa D. Norman Ing, Po’okela K. Ng and Claire E. Kendal-Wright

Biomolecules, 2022, 12, 766
DOI: 10.3390/biom12060766

BACH1-Hemoxygenase-1 axis regulates cellular energetics and survival following sepsis

Lun Cai, Ali S. Arbab, Tae Jin Lee, Ashok Sharma, Bobby Thomas, Kazuhiko Igarashi and Raghavan Pillai Raju

Free Radical Biology and Medicine, 2022, 188, 134
DOI: 10.1016/j.freeradbiomed.2022.06.005

Decreased autophagosome biogenesis, reduced NRF2, and enhanced ferroptotic cell death are underlying molecular mechanisms of non-alcoholic fatty liver disease

Pengfei Liu, Annadurai Anandhan, Jinjing Chen, Aryatara Shakya, Matthew Dodson, Aikseng Ooi, Eli Chapman, Eileen White, Joe GN. Garcia and Donna D. Zhang

Redox Biology, 2023, 59, 102570
DOI: 10.1016/j.redox.2022.102570

Natural products targeting Nrf2/ARE signaling pathway in the treatment of inflammatory bowel disease

Botong Li, Yixuan Wang, Xiaolin Jiang, Hongwei Du, Yan Shi, Minghui Xiu, Yongqi Liu and Jianzheng He

Biomedicine & Pharmacotherapy, 2023, 164, 114950
DOI: 10.1016/j.biopha.2023.114950

Natural Products in the Prevention of Degenerative Bone and Joint Diseases: Mechanisms Based on the Regulation of Ferroptosis

Kuanhui Gao, Longlong Lv, Zhichao Li, Chenmoji Wang, Jiahao Zhang, Daodi Qiu, Haipeng Xue, Zhanwang Xu and Guoqing Tan

Phytotherapy Research, 2025, 39, 162
DOI: 10.1002/ptr.8366

Quercetin-liposomes effectively regulated the Nrf2/Keap1 and NF-κB/P38 MAPK signaling pathways and protected the liver against paracetamol-induced damage

Fatma El Zahraa A. Elkady, Walaa A. Moselhy, Fatma I. Abo El-Ela, Abeer M. Abd El-Hameed and Mohamed I. Zanaty

Journal of Genetic Engineering and Biotechnology, 2025, 23, 100617
DOI: 10.1016/j.jgeb.2025.100617

Flavonoids from Polypodium hastatum as neuroprotective agents attenuate cerebral ischemia/reperfusion injury in vitro and in vivo via activating Nrf2

Huankai Yao, Ruiqing Wu, Dan Du, Fengwei Ai, Feng Yang, Yan Li and Suhua Qi

Redox Report, 2025, 30
DOI: 10.1080/13510002.2024.2440204

Quercetin Attenuates Quinocetone-Induced Cell Apoptosis In Vitro by Activating the P38/Nrf2/HO-1 Pathway and Inhibiting the ROS/Mitochondrial Apoptotic Pathway

Chongshan Dai, Qinzhi Zhang, Linjie Shen, Gaurav Sharma, Haiyang Jiang, Zhanhui Wang and Jianzhong Shen

Antioxidants, 2022, 11, 1498
DOI: 10.3390/antiox11081498

Role of Natural Compounds Modulating Heme Catabolic Pathway in Gut, Liver, Cardiovascular, and Brain Diseases

Sri Jayanti, Libor Vitek, Camilla Dalla Verde, John Paul Llido, Caecilia Sukowati, Claudio Tiribelli and Silvia Gazzin

Biomolecules, 2024, 14, 63
DOI: 10.3390/biom14010063

A scientometrics and visualization analysis of oxidative stress modulator Nrf2 in cancer profiles its characteristics and reveals its association with immune response

Song-Bin Guo, Sheng Du, Ke-Yu Cai, Han-Jia Cai, Wei-Juan Huang and Xiao-Peng Tian

Heliyon, 2023, 9, e17075
DOI: 10.1016/j.heliyon.2023.e17075

Ribisins and Certain Analogues Exert Neuroprotective Effects through Activation of the Keap1‐Nrf2‐ARE Pathway

Shen H. Tan, Muthukumar Karuppasamy, Ping Lan, Yaochun Zhang, Jiayi Hu, Xingchen Lai, Belinda Siok‐Cheng Lim, Weiliang Liu, Jing Chen, Eng‐Hui Chew and Martin G. Banwell

ChemMedChem, 2022, 17
DOI: 10.1002/cmdc.202200292

Current Landscape of NRF2 Biomarkers in Clinical Trials

Yoko Yagishita, Tonibelle N. Gatbonton-Schwager, Melissa L. McCallum and Thomas W. Kensler

Antioxidants, 2020, 9, 716
DOI: 10.3390/antiox9080716

Effective Amelioration of Alzheimer's Disease in Preclinical Models With Electrophilic Compounds via Nrf2 Pathway Activation

Lie Yuan, Muhammad Arif Asghar, Yazhen Zhang, Yuanyuan Yang, Xiao Zhang and Qinjian Zhao

J Biochem & Molecular Tox, 2026, 40
DOI: 10.1002/jbt.70909

Roles of Oxidative Stress and Nrf2 Signaling in Pathogenic and Non-Pathogenic Cells: A Possible General Mechanism of Resistance to Therapy

Mira Hammad, Mohammad Raftari, Rute Cesário, Rima Salma, Paulo Godoy, S. Noushin Emami and Siamak Haghdoost

Antioxidants, 2023, 12, 1371
DOI: 10.3390/antiox12071371

NRF2-mediated persistent adaptation of oesophageal adenocarcinoma cells to HER2 inhibition

Wei Zhang, Jiaqing Lang, Sorayut Chattrakarn, Chun Wai Wong, Shiyang Li, Karmern Kan, Hongcai Liu, Wenchao Gu, Jingwei Zhang, Jukka Westermarck, Alan J. Whitmarsh, Andrew D. Sharrocks and Cathy Tournier

Oncogene, 2025, 44, 2929
DOI: 10.1038/s41388-025-03459-0

Design and synthesis of isothiocyanate‐containing hybrid androgen receptor (AR) antagonist to downregulate AR and induce ferroptosis in GSH–Deficient prostate cancer cells

Zhihui Qin, Siyu Ou, Liping Xu, Kathleen Sorensen, Yingxue Zhang, Dan‐Ping Hu, Zhe Yang, Wen‐Yang Hu, Fei Chen and Gail S. Prins

Chem Biol Drug Des, 2021, 97, 1059
DOI: 10.1111/cbdd.13826

Activation of Nrf2 pathway as a protective mechanism against oxidative stress-induced diseases: Potential of astaxanthin

Osman N. Kanwugu and Tatiana V. Glukhareva

Archives of Biochemistry and Biophysics, 2023, 741, 109601
DOI: 10.1016/j.abb.2023.109601

Cucurbitacin E Triggers Cellular Senescence in Colon Cancer Cells via Regulating the miR-371b-5p/TFAP4 Signaling Pathway

Peng Yang, Qing Lian, Rong Fu, Guo-bin Ding, Sajid Amin, Zongwei Li and Zhuoyu Li

J. Agric. Food Chem., 2022, 70, 2936
DOI: 10.1021/acs.jafc.1c07952

Remimazolam Alleviates Neuronal Oxygen Glucose Deprivation/Re-Oxygenation Injury in Rats by Keap1/Nrf2 Signaling Pathway

伯珏仇

ACM, 2023, 13, 1267
DOI: 10.12677/ACM.2023.132175

Stretch Causes cffDNA and HMGB1-Mediated Inflammation and Cellular Stress in Human Fetal Membranes

Justin Gary Padron, Chelsea A. Saito Reis, Po’okela K. Ng, Nainoa D. Norman Ing, Hannah Baker, Kamalei Davis, Courtney Kurashima and Claire E. Kendal-Wright

IJMS, 2024, 25, 5161
DOI: 10.3390/ijms25105161

Liquiritigenin Confers Liver Protection by Enhancing NRF2 Signaling through Both Canonical and Non-canonical Signaling Pathways

Mengjiao Shi, Jian Zhang, Miaomiao Li, Yaping Zhao, Ying Guo, Jiayi Xu, Rongrong Liu, Zongfang Li, Dongmei Ren and Pengfei Liu

J. Med. Chem., 2023, 66, 11324
DOI: 10.1021/acs.jmedchem.3c00815

Mechanistic investigation of the ameliorative effect of crocin on arsenic trioxide-induced HT22 nerve cells injury based on network pharmacology and in vitro validation

Chen Li, Mengqi Xian, Jiaze Liu, Yahui An, Xiaoxia Di, Jintuo Yin, Yalan Zuo, Xi Chu, Hefei Wang and Xue Han

Neuroscience, 2026, 609, 1
DOI: 10.1016/j.neuroscience.2026.05.021

A General Signal Pathway to Regulate Multiple Detoxification Genes Drives the Evolution of Helicoverpa armigera Adaptation to Xenobiotics

Lei Zhang, Shenglan Lv, Mingjian Li, Meng Gu and Xiwu Gao

IJMS, 2022, 23, 16126
DOI: 10.3390/ijms232416126

Natural Products Inspired Scaffold Diversification Leads to Unnatural Molecular Warhead and Covalent Strategy to Modulating Protein Function through Electrophilic Bromine Transfer

Beau R. Brummel, Sofia Kokkaliari, Qiwen Gao, Jinjing Chen, Larissa Costa de Almeida, Srinivasarao Tenneti, Derek A. Leas, Eli Levit, Lewis S. Alexander, Khalil A. Abboud, Pingrong Wei, Michael D. Cameron, James R. Rocca, Ranjala Ratnayake, Donna D. Zhang, Hendrik Luesch and Robert W. Huigens

Advanced Science, 2026
DOI: 10.1002/advs.202512849

Gaudichaudione H Enhances the Sensitivity of Hepatocellular Carcinoma Cells to Disulfidptosis via Regulating NRF2‐SLC7A11 Signaling Pathway

Mengjiao Shi, Xinyan Li, Ying Guo, Yinggang Zhang, Jiayi Xu, Liangwen Yan, Rongrong Liu, Hong Wang, Shenkang Tang, Yaping Zhao, Zongfang Li, Yetong Feng, Dongmei Ren and Pengfei Liu

Advanced Science, 2025, 12
DOI: 10.1002/advs.202411131

Phelligridin D from Inonotus obliquus attenuates oxidative stress and accumulation of ECM in mesangial cells under high glucose via activating Nrf2

Yan Li, Yang Zhou, Jing Wu, Jindong Li and Huankai Yao

J Nat Med, 2021, 75, 1021
DOI: 10.1007/s11418-021-01534-w

Z-REX uncovers a bifurcation in function of Keap1 paralogs

Alexandra Van Hall-Beauvais, Jesse R Poganik, Kuan-Ting Huang, Saba Parvez, Yi Zhao, Hong-Yu Lin, Xuyu Liu, Marcus John Curtis Long and Yimon Aye

eLife, 2022, 11
DOI: 10.7554/eLife.83373

NRF2 Suppression Enhances the Susceptibility of Pancreatic Cancer Cells, Miapaca-2 to Paclitaxel

Negin Riazi-Tabrizi, Mohammad Khalaj-Kondori, Sahar Safaei, Mohammad Amini, Hamidreza Hassanian, Mohadeseh Maghsoudi, Shima Hasani and Behzad Baradaran

Mol Biotechnol, 2024, 66, 2441
DOI: 10.1007/s12033-023-00872-2

Nuclear factor erythroid 2-related factor 2 (Nrf2) inhibition revisited: advances and unmet challenges

Mengchen Lu, Ziyu Yang, Yabing Xin, Yuan Zhang, Shutong Jiang, Jingyu Zhu, Qidong You, Ziquan Zhao and Zhengyu Jiang

Journal of Advanced Research, 2026
DOI: 10.1016/j.jare.2026.05.030

Naringin alleviates acetaminophen‐induced acute liver injury by activating Nrf2 via CHAC2 upregulation

Xiaohan Zhai, Tiantian Dai, Zhongchao Chi, Zirui Zhao, Gaolei Wu, Shilei Yang and Deshi Dong

Environmental Toxicology, 2022, 37, 1332
DOI: 10.1002/tox.23487

The Role of Nrf2 in Relieving Cerebral Ischemia-Reperfusion Injury

Yu Sun, Xu Yang, Lijun Xu, Mengxiao Jia, Limeng Zhang, Peng Li and Pengfei Yang

CN, 2023, 21, 1405
DOI: 10.2174/1570159X21666221129100308

Flavonoids as Modulators of Nrf2 Signaling Pathway in Alleviating Cisplatin-Induced Organ Toxicity

Xin Zhang, Jiwei Qian, Butian Wei and Bo Zhang

YM, 2025, 09, 52
DOI: 10.4236/ym.2025.91006

Ferroptosis‐modulating small molecules for targeting drug‐resistant cancer: Challenges and opportunities in manipulating redox signaling

Solveigh C. Koeberle, Anna P. Kipp, Hermann Stuppner and Andreas Koeberle

Medicinal Research Reviews, 2023, 43, 614
DOI: 10.1002/med.21933

Astragaloside IV alleviates 1-deoxysphinganine-induced mitochondrial dysfunction during the progression of chronic kidney disease through p62-Nrf2 antioxidant pathway

Ting Gui, Qingfa Chen, Jiangsong Li, Ke Lu, Chen Li, Bin Xu, Yang Chen, Jingwen Men, Gerd A. Kullak-Ublick, Weihua Wang and Zhibo Gai

Front. Pharmacol., 2023, 14
DOI: 10.3389/fphar.2023.1092475

Therapeutic Effects of Natural Products in the Treatment of Chronic Diseases: The Role in Regulating KEAP1–NRF2 Pathway

Yaling Li, Xijia Wang, Shuyue Li, Lei Wang, Ningning Ding, Yali She and Changtian Li

Am. J. Chin. Med., 2025, 53, 67
DOI: 10.1142/S0192415X25500041

Aldo-keto reductase-7A2 protects against atorvastatin-induced hepatotoxicity via Nrf2 activation

Dan Li, Jiajin Chen, Fei Zhou, Wenhe Zhang and Hongyu Chen

Chemico-Biological Interactions, 2024, 393, 110956
DOI: 10.1016/j.cbi.2024.110956

Discovery of caffeoylisocitric acid as a Keap1-dependent Nrf2 activator and its effects in mesangial cells under high glucose

Huankai Yao, Wenting Zhang, Feng Yang, Fengwei Ai, Dan Du and Yan Li

Journal of Enzyme Inhibition and Medicinal Chemistry, 2022, 37, 178
DOI: 10.1080/14756366.2021.1998025

BIOFLAVONOIDS AS AGENTS FOR CORRECTING NITRO-OXIDATIVE STRESS AND SALIVARY GLAND FUNCTIONS IN RATS EXPOSED TO ALCOHOL DURING MODELED LIPOPOLYSACCHARIDE-INDUCED SYSTEMIC INFLAMMATORY RESPONSE

Rita Kozaeva, Mykola O. Klymenko, Oleksandr V. Katrushov and Vitalii O. Kostenko

Wiad Lek, 2022, 75, 685
DOI: 10.36740/WLek202203121

The Emerging Role of Immune Cells and Targeted Therapeutic Strategies in Diabetic Wounds Healing

Jianying Song, Lixin Hu, Bo Liu, Nan Jiang, Houqiang Huang, JieSi Luo, Long Wang, Jing Zeng, Feihong Huang, Min Huang, Luyao Cai, Lingyu Tang, Shunli Chen, Yinyi Chen, Anguo Wu, Silin Zheng and Qi Chen

JIR, 2022, Volume 15, 4119
DOI: 10.2147/JIR.S371939

Oxidised rice bran oil induced oxidative stress and apoptosis in IPEC‐J2 cells via the Nrf2 signalling pathway

Ruqi Wang, Chuanqi Wang, Peide Chen, Huiyu Qi and Jing Zhang

Animal Physiology Nutrition, 2024, 108, 1844
DOI: 10.1111/jpn.14025

Identification of Beilschmiedia tsangii Root Extract as a Liver Cancer Cell–Normal Keratinocyte Dual-Selective NRF2 Regulator

Yi-Siao Chen, Hsun-Shuo Chang, Hui-Hua Hsiao, Yih-Fung Chen, Yi-Ping Kuo, Feng-Lin Yen and Chia-Hung Yen

Antioxidants, 2021, 10, 544
DOI: 10.3390/antiox10040544

Neuroprotection Against a Panel of Toxicants via a Novel Analog of the Natural Product Fraxinellone

Anna E. Bartman, Michael A. Garcia-Mares, Sarah E. Preston, Mersad Raeisi, Clarence D. Peiris, David B. C. Martin, Hans-Joachim Lehmler and Jonathan A. Doorn

Chem. Res. Toxicol., 2026, 39, 908
DOI: 10.1021/acs.chemrestox.5c00522

Tetramethylpyrazine ameliorates endotoxin-induced acute lung injury by relieving Golgi stress via the Nrf2/HO-1 signaling pathway

Shaona Li, Yexiang Xu, Simeng He, Xiangyun Li, Jia Shi, Bing Zhang, Youzhuang Zhu, Xiangkun Li, Yanting Wang, Cuicui Liu, Yang Ma, Shuan Dong and Jianbo Yu

BMC Pulm Med, 2023, 23
DOI: 10.1186/s12890-023-02585-3

Natural Nrf2 Activators from Juices, Wines, Coffee, and Cocoa

Mallique Qader, Jian Xu, Yuejun Yang, Yuancai Liu and Shugeng Cao

Beverages, 2020, 6, 68
DOI: 10.3390/beverages6040068

Mitochondrial mechanisms in Cerebral Ischemia-Reperfusion Injury: Unravelling the intricacies

Shiv Kumar Saini and Damanpreet Singh

Mitochondrion, 2024, 77, 101883
DOI: 10.1016/j.mito.2024.101883

Oncogenic stress response mechanisms as new therapeutic targets in cancer treatment: A review

Juan Iovanna, Matías Estaras, Daniel Grasso, Martin E. Fernández Zapico, Jose Luis Neira and Patricia Santofimia-Castaño

Medicine, 2025, 104, e42857
DOI: 10.1097/MD.0000000000042857

Medicinal Chemistry Insights into the Development of Small-Molecule Kelch-Like ECH-Associated Protein 1-Nuclear Factor Erythroid 2-Related Factor 2 (Keap1–Nrf2) Protein–Protein Interaction Inhibitors

Ziquan Zhao, Ruitian Dong, Qidong You and Zhengyu Jiang

J. Med. Chem., 2023, 66, 9325
DOI: 10.1021/acs.jmedchem.3c00712

Brusatol sensitizes endometrial hyperplasia and cancer to progestin by suppressing NRF2-TET1-AKR1C1-mediated progestin metabolism

Meiyan Hu, Di Sun, Jing Yu, Yue Fu, Zuoshu Qin, Baozhu Huang, Qiuju Zhang, Xiong Chen, Youheng Wei, Huiting Zhu, Yue Wang, Youji Feng, Wenxin Zheng, Hong Liao, Jingjie Li, Sufang Wu and Zhenbo Zhang

Laboratory Investigation, 2022, 102, 1335
DOI: 10.1038/s41374-022-00816-5

PSMD12 promotes non-small cell lung cancer progression through activating the Nrf2/TrxR1 pathway

Junqi Lv, Shengmao Ma, Xiaowen Wang, Jifang Dang and Fuchun Ma

Genes Genom, 2024, 46, 263
DOI: 10.1007/s13258-023-01484-5

Nrf2 Modulation by Natural Compounds in Aging, Neurodegeneration, and Neuropathic Pain

Jurga Bernatoniene, Dalia M. Kopustinskiene, Roberto Casale, Alessandro Medoro, Sergio Davinelli, Luciano Saso and Kestutis Petrikonis

Pharmaceutics, 2026, 18, 118
DOI: 10.3390/pharmaceutics18010118

Anti-Inflammatory Activity of Monosubstituted Xestoquinone Analogues from the Marine Sponge Neopetrosia compacta

Shalice R. Susana and Lilibeth A. Salvador-Reyes

Antioxidants, 2022, 11, 607
DOI: 10.3390/antiox11040607

Antioxidants attenuate mitochondrial oxidative damage through the Nrf2 pathway: A promising therapeutic strategy for stroke

Ling Chen, Su Chen, Xiao‐Fei Yang and Jia‐Wei Min

J of Neuroscience Research, 2023, 101, 1275
DOI: 10.1002/jnr.25194

Drug-induced oxidative stress in cancer treatments: Angel or devil?

Hao Jiang, Jing Zuo, Bowen Li, Rui Chen, Kangjia Luo, Xionghua Xiang, Shuaijun Lu, Canhua Huang, Lin Liu, Jing Tang and Feng Gao

Redox Biology, 2023, 63, 102754
DOI: 10.1016/j.redox.2023.102754

Why natural antioxidants are readily recognized by biological systems? 3D architecture plays a role!

Zai-Qun Liu

Food Chemistry, 2022, 380, 132143
DOI: 10.1016/j.foodchem.2022.132143

Design and synthesis of trolline derivatives with Nrf2 pathway-associated anti-inflammatory activity

Bill Zhereng Liao, Qi-Mei Tan, Ya-Lin Li, Yu-Xia Wang, Ling-Yi Kong and Jian-Guang Luo

Bioorganic & Medicinal Chemistry Letters, 2026, 138, 130688
DOI: 10.1016/j.bmcl.2026.130688

Protective effects of natural compounds against paraquat-induced pulmonary toxicity: the role of the Nrf2/ARE signaling pathway

Hasan Badibostan, Nastaran Eizadi-Mood, A. Wallace Hayes and Gholamreza Karimi

International Journal of Environmental Health Research, 2024, 34, 611
DOI: 10.1080/09603123.2022.2163985

Endogenous hydrogen sulfide counteracts polystyrene nanoplastics-induced mitochondrial apoptosis and excessive autophagy via regulating Nrf2 and PGC-1α signaling pathway in mouse spermatocyte-derived GC-2spd(ts) cells

Siwen Li, Yu Ma, Shuzi Ye, Ying Su, Die Hu and Fang Xiao

Food and Chemical Toxicology, 2022, 164, 113071
DOI: 10.1016/j.fct.2022.113071

Triterpenoids from the roots of Sanguisorba officinalis and their Nrf2 stimulation activity

Longlong Wu, Jingwen Liu, Kaixian Chen, Liuqiang Zhang and Yiming Li

Phytochemistry, 2023, 214, 113803
DOI: 10.1016/j.phytochem.2023.113803

Constitutive Activation of Nrf2 in Mice Expands Enterogenesis in Small Intestine Through Negative Regulation of Math1

Yoko Yagishita, Melissa L. McCallum, Thomas W. Kensler and Nobunao Wakabayashi

Cellular and Molecular Gastroenterology and Hepatology, 2021, 11, 503
DOI: 10.1016/j.jcmgh.2020.08.013

Maackiain protects against sepsis via activating AMPK/Nrf2/HO-1 pathway

Xiaoxue Bai, Yingjie Zhu, Jing Jie, Dan Li, Lei Song and Jingjing Luo

International Immunopharmacology, 2022, 108, 108710
DOI: 10.1016/j.intimp.2022.108710

Roles of NRF2 in DNA damage repair

Jiale Li, Chang Xu and Qiang Liu

Cell Oncol., 2023, 46, 1577
DOI: 10.1007/s13402-023-00834-5

Nrf2 as a Molecular Guardian of Redox Balance and Barrier Integrity in IBD

Bojan Stojanovic, Ivana Milivojcevic Bevc, Milica Dimitrijevic Stojanovic, Bojana S. Stojanovic, Marina Jovanovic, Snezana Lazarevic, Bojan Milosevic, Ivan Radosavljevic, Danijela Tasic-Uros, Nenad Markovic, Đorđe Todorovic, Irfan Corovic, Filip Milutinovic, Damnjan Pantic, Mladen Maksic and Snezana Lukic

Antioxidants, 2025, 14, 1407
DOI: 10.3390/antiox14121407

Linagliptin ameliorates tacrolimus-induced renal injury: role of Nrf2/HO-1 and HIF-1α/CTGF/PAI-1

Mohamed E. Nady, Ola M. Abd El-Raouf and El-Sayed M. El-Sayed

Mol Biol Rep, 2024, 51
DOI: 10.1007/s11033-024-09533-2

An integrative strategy for discovery of functional compound combination from Traditional Chinese Medicine: Danhong Injection as a model

Zhixiong Wang, Haofang Wan, Xin Tong, Yu He, Jiehong Yang, Ling Zhang, Chongyu Shao, Zhishan Ding, Haitong Wan and Chang Li

Biomedicine & Pharmacotherapy, 2021, 138, 111451
DOI: 10.1016/j.biopha.2021.111451

An updated patent review of Nrf2 activators (2020-present)

Ziquan Zhao, Ruitian Dong, Keni Cui, Qidong You and Zhengyu Jiang

Expert Opinion on Therapeutic Patents, 2023, 33, 29
DOI: 10.1080/13543776.2023.2178299

Inaugurating a novel adjuvant therapy in urological cancers: Ferroptosis

Zhaoxiang Xie, Qianghua Zhou, Cheng Qiu, Dingjun Zhu, Kaiwen Li and Hai Huang

Cancer Pathogenesis and Therapy, 2023, 1, 127
DOI: 10.1016/j.cpt.2022.10.002

Auranofin-loaded chitosan-lipid hybrid nanoparticle protects against rotenone model of Parkinson's disease via modulation of GSK-3β/ Nrf2/HO-1 signaling

Divya Soni, Yogesh Garg, Shubham Upadhayay, Amit Bhatia, Bushra Basir, Sachin Kumar Singh, Kamal Dua and Puneet Kumar

European Journal of Pharmacology, 2025, 998, 177523
DOI: 10.1016/j.ejphar.2025.177523

STAT6/VDR Axis Mitigates Lung Inflammatory Injury by Promoting Nrf2 Signaling Pathway

Youjing Yang, Qianmin Li, Shuhui Wei, Kaimiao Chu, Lian Xue, Jie Liu, Yu Ma, Shasha Tao and Maria Isaguliants

Oxidative Medicine and Cellular Longevity, 2022, 2022
DOI: 10.1155/2022/2485250

Swinhoeic acid from Potentilla fragarioides ameliorates high glucose-induced oxidative stress and accumulation of ECM in mesangial cells via Keap1-dependent activation of Nrf2

Huankai Yao, Min Kong, Dan Du, Fengwei Ai, Jindong Li and Yan Li

Redox Report, 2022, 27, 230
DOI: 10.1080/13510002.2022.2134755

Dietary Phytochemicals Targeting Nrf2 to Enhance the Radiosensitivity of Cancer

Pinghan Wang, Fangyi Long, Hong Lin, Song Wang, Ting Wang and H. P. Vasantha Rupasinghe

Oxidative Medicine and Cellular Longevity, 2022, 2022
DOI: 10.1155/2022/7848811

Dietary Supplements as Modulators of the Nrf2 Pathway to Enhance Intracellular Antioxidant Responses and Protect Against Dyslipidemia-Associated Cardiovascular Complications

Sinenhlanhla X. H. Mthembu, Sithandiwe E. Mazibuko-Mbeje, Sonia Silvestri, Patrick Orlando, Bongani B. Nkambule, Christo J. F. Muller, Luca Tiano and Phiwayinkosi V. Dludla

Food Reviews International, 2025, 41, 1440
DOI: 10.1080/87559129.2024.2449378

Ocotillol Derivatives Mitigate Retinal Ischemia-Reperfusion Injury by Regulating the Keap1/Nrf2/ARE Signaling Pathway

Xin Zhang, Wen Zhang, Laien Zhao, Gongshan Ma, Yanmei Huang, Zhiyuan Geng, Qian Jiang, Xiaomei Wen, Yuqi Lin, Qingguo Meng, Zhuhong Zhang and Yi Bi

J. Med. Chem., 2024, 67, 15268
DOI: 10.1021/acs.jmedchem.4c00867

Avenanthramide C induces cellular senescence in colorectal cancer cells via suppressing β-catenin-mediated the transcription of miR-183/96/182 cluster

Rong Fu, Zhangfeng Dou, Ning Li, Jinqi Zhang, Zhuoyu Li and Peng Yang

Biochemical Pharmacology, 2022, 199, 115021
DOI: 10.1016/j.bcp.2022.115021

Lysionotin Induces Ferroptosis to Suppress Development of Colorectal Cancer via Promoting Nrf2 Degradation

Zhuo Gao, Junnan Jiang, Lijian Hou, Fujian Ji and Yanqing Liu

Oxidative Medicine and Cellular Longevity, 2022, 2022
DOI: 10.1155/2022/1366957

NRF2 and the Ambiguous Consequences of Its Activation during Initiation and the Subsequent Stages of Tumourigenesis

Holly Robertson, Albena T. Dinkova-Kostova and John D. Hayes

Cancers, 2020, 12, 3609
DOI: 10.3390/cancers12123609

Targeting NRF2 to treat cancer

Jared Sivinski, Donna D. Zhang and Eli Chapman

Seminars in Cancer Biology, 2021, 76, 61
DOI: 10.1016/j.semcancer.2021.06.003

The role of Nrf2 signaling pathways in nerve damage repair

Arash Abdolmaleki, Aida Karimian, Seyedeh Mahdieh Khoshnazar, Asadollah Asadi, Zahra Akhavi Samarein, Shukur Wasman Smail and Deepak Bhattacharya

Toxicology Research, 2024, 13
DOI: 10.1093/toxres/tfae080

NRF-mediated autophagy and UPR: Exploring new avenues to overcome cancer chemo-resistance

Sanaz Dastghaib, Sayed Mohammad Shafiee, Fatemeh Ramezani, Niloufar Ashtari, Farhad Tabasi, Javad Saffari-Chaleshtori, Morvarid Siri, Omid Vakili, Somayeh Igder, Mozhdeh Zamani, Maryam Niknam, Mahshid Moballegh Nasery, Fariba Kokabi, Emilia Wiechec, Zohreh Mostafavi-Pour, Pooneh Mokarram and Saeid Ghavami

European Journal of Pharmacology, 2025, 988, 177210
DOI: 10.1016/j.ejphar.2024.177210

A Comparative Analysis of Chemical Constituents and Antioxidant Effects of Dendrobium fimbriatum Hook Fractions with Different Polarities

Tianrui Zhao, Fangyuan Zheng, Yaping Liu, Afsar Khan, Zhengxuan Wang and Guiguang Cheng

IJMS, 2023, 24, 12646
DOI: 10.3390/ijms241612646

Exploring the broad-spectrum activity of carbohydrate-based Iberin analogues: From anticancer effect to antioxidant properties

L.A. Prieto, N. Khiar-Fernández, J.M. Calderón-Montaño, M. López-Lázaro, J. Lucía-Tamudo, J.J. Nogueira, R. León, N. Moreno, V. Valdivia, R. Recio and I. Fernández

European Journal of Medicinal Chemistry, 2025, 289, 117469
DOI: 10.1016/j.ejmech.2025.117469

Natural Nrf2 Modulators for Skin Protection

Yong Chool Boo

Antioxidants, 2020, 9, 812
DOI: 10.3390/antiox9090812

Nrf2: The Master and Captain of Beta Cell Fate

Sharon Baumel-Alterzon, Liora S. Katz, Gabriel Brill, Adolfo Garcia-Ocaña and Donald K. Scott

Trends in Endocrinology & Metabolism, 2021, 32, 7
DOI: 10.1016/j.tem.2020.11.002

Zanthoxylum schinifolium seed lignans as potential functional food ingredients: Anti-inflammatory and antioxidant properties

Jiahao Yuan, Xunyao Zhang, Mohan Li, Xiaowei Peng, Dunhe Zhang, Chenhao Jiang, Huijing Chen and Jianquan Kan

Food Bioscience, 2026, 81, 109109
DOI: 10.1016/j.fbio.2026.109109

Natural Biologics Accelerate Healing of Diabetic Foot Ulcers by Regulating Oxidative Stress

Jianying Song, Aiai Liu, Bo Liu, Wei Huang, Zongzhe Jiang, Xue Bai, Lixin Hu, Silin Zheng, Shengming Guo, Jianming Wu and Qi Chen

Front. Biosci. (Landmark Ed), 2022, 27
DOI: 10.31083/j.fbl2710285

Nrf2 induction potency of plant-derived compounds determined using an antioxidant response element luciferase reporter and conventional NAD(P)H-quinone acceptor oxidoreductase 1 activity assay

Erina Tamaru, Daichi Kokubu, Yusuke Ushida and Ken Itoh

BMC Res Notes, 2024, 17
DOI: 10.1186/s13104-024-07038-6

Cafestol, Kahweol and Their Acylated Derivatives: Antitumor Potential, Pharmacokinetics, and Chemopreventive Profile

M.A.E. Silva, A.L.M. Brand, F.J.M. Novaes and C.M Rezende

Food Reviews International, 2023, 39, 7048
DOI: 10.1080/87559129.2022.2141776

Sulforaphane Inhibits Foam Cell Formation and Atherosclerosis via Mechanisms Involving the Modulation of Macrophage Cholesterol Transport and the Related Phenotype

Shiyan Liu, Yuan Zhang, Xiangyu Zheng, Ziling Wang, Pan Wang, Mengdi Zhang, Mengfan Shen, Yongping Bao and Dan Li

Nutrients, 2023, 15, 2117
DOI: 10.3390/nu15092117

Tempe as superior functional antioxidant food: From biomechanism to future development of soybean-based functional food

Reggie Surya, Nurlinah Amalia, William Ben Gunawan, Nurpudji Astuti Taslim, Marwan Ghafoor, Nelly Mayulu, Hardinsyah Hardinsyah, Rony Abdi Syahputra, Felicia Kartawidjajaputra, Gianluca Rizzo, Raymond Rubianto Tjandrawinata, Dionysius Subali, Rudy Kurniawan and Fahrul Nurkolis

PHAR, 2024, 71, 1
DOI: 10.3897/pharmacia.71.e116748

Inhibition of smooth muscle phenotypic modulation by bardoxolone methyl, omaveloxolone, and cinnamaldehyde is Nrf-2 dependent

Danial Babaki, Nicholas E. Buglak, Bruno Musetti, Yasmin Leon-Mateo, Gang Xi and Edward M. Bahnson

Advances in Redox Research, 2026, 18, 100158
DOI: 10.1016/j.arres.2026.100158

Rosmarinic acid activates the Nrf2/HO-1 axis and suppresses NF-κB to protect against gentamicin-induced acute kidney injury

Olatunji Nozeem Salako, Martin Desimone, Vincent Chukwuemeka Eze and Modupe Adebanji Akingbade

Biomedicine & Pharmacotherapy, 2026, 199, 119503
DOI: 10.1016/j.biopha.2026.119503

Tiliroside from Potentilla chinensis attenuates oxidative stress and accumulation of ECM in mesangial cells under high glucose via activating Nrf2

Huankai Yao, Ruoxi Zhao, Bangcheng Gu, Mengmeng Fu, Feng Yang, Yan Li and Changjiang Ying

Journal of Functional Foods, 2023, 110, 105842
DOI: 10.1016/j.jff.2023.105842

Short-chain fatty acids as modulators of redox signaling in health and disease

Carmen González-Bosch, Emily Boorman, Patricia A. Zunszain and Giovanni E. Mann

Redox Biology, 2021, 47, 102165
DOI: 10.1016/j.redox.2021.102165

Sanguisorba officinalis L. promotes diabetic wound healing in rats through inflammation response mediated by macrophage

Jianying Song, Jing Zeng, Silin Zheng, Nan Jiang, Anguo Wu, Shengming Guo, Rupei Ye, Lixin Hu, Feihong Huang, Long Wang, Zhou Xiaogang, Bo Liu, Jianming Wu and Qi Chen

Phytotherapy Research, 2023, 37, 4265
DOI: 10.1002/ptr.7906

Natural products as non-covalent and covalent modulators of the KEAP1/NRF2 pathway exerting antioxidant effects

Giulia Culletta, Brigitta Buttari, Marzia Arese, Simone Brogi, Anna Maria Almerico, Luciano Saso and Marco Tutone

European Journal of Medicinal Chemistry, 2024, 270, 116355
DOI: 10.1016/j.ejmech.2024.116355

Repositioning Brusatol as a Transmission Blocker of Malaria Parasites

Amelia Cox, Neelima Krishnankutty, Steven Shave, Virginia M. Howick, Manfred Auer, James J. La Clair and Nisha Philip

ACS Infect. Dis., 2024, 10, 3586
DOI: 10.1021/acsinfecdis.4c00434

Quercetin Targets HSP90α and Regulates Keap1/Nrf2 Pathway to Inhibit Crosstalk between Apoptosis and Ferroptosis in Oxidatively Stressed Neurons

Jing Liu, Zhe‐Zuo Zhang, Gu‐Ran Yu and Xu Han

J Biochem & Molecular Tox, 2025, 39
DOI: 10.1002/jbt.70583

Medicinal-chemistry-driven strategies for the synthesis of antiosteoclastogenic small molecules targeting RANKL and its downstream signaling pathways

Abdul Basit and Siyuan Wang

European Journal of Medicinal Chemistry, 2026, 308, 118665
DOI: 10.1016/j.ejmech.2026.118665

Gaudichaudione H ameliorates liver fibrosis and inflammation by targeting NRF2 signaling pathway

Mengjiao Shi, Ying Guo, Jiayi Xu, Liangwen Yan, Xinyan Li, Rongrong Liu, Yetong Feng, Yinggang Zhang, Yaping Zhao, Chongyu Zhang, Ke Du, Miaomiao Li, Yi Zhang, Jian Zhang, Zongfang Li, Dongmei Ren and Pengfei Liu

Free Radical Biology and Medicine, 2024, 224, 770
DOI: 10.1016/j.freeradbiomed.2024.09.020

Astragaloside IV Alleviates Tacrolimus-Induced Chronic Nephrotoxicity via p62-Keap1-Nrf2 Pathway

Ping Gao, Xiaoyi Du, Lili Liu, Hua Xu, Maochang Liu, Xinlei Guan and Chengliang Zhang

Front. Pharmacol., 2021, 11
DOI: 10.3389/fphar.2020.610102