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An Overview of the Medicinally Important Plant Type III PKS Derived Polyketides

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Design and application of a novel acridine-based fluorophore BAA12C as a theranostic agent

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New Poly(Propylene Imine) Dendrimer Modified with Acridine and Its Cu(II) Complex: Synthesis, Characterization and Antimicrobial Activity

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Acenaphthylene-Fused Angular and Linear π-Extension of Acridone

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Natural acridones and coumarins as free radical scavengers: Mechanistic and kinetic studies

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Evaluation of N10-substituted acridone-based derivatives as AKT inhibitors against breast cancer cells: in vitro and molecular docking studies

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9-Aminoacridine-based agents impair the bovine viral diarrhea virus (BVDV) replication targeting the RNA-dependent RNA polymerase (RdRp)

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Synthesis and Biological Evaluation of m-PEG Attached Acridinedione Derivatives as Antimicrobial, Antioxidant and Anticancer Agents

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Novel therapeutic compound acridine–retrotuftsin action on biological forms of melanoma and neuroblastoma

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Synthesis of new 1H‐spiro[acridine‐9,3′‐indoline]‐1,2′(2H,10H)‐dione derivatives using aqueous ethanol as a reaction medium

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Mitochondria-targeted acridine-based dual-channel fluorescence chemosensor for detection of Sn4+ and Cr2O72- ions in water and its application in discriminative detection of cancer cells

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Apoptotic and antioxidant effects in HCT-116 colorectal carcinoma cells by a spiro-acridine compound, AMTAC-06

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Innovative and sustainable synthesis and structure of novel N‐substituted hexahydroacridine derivatives

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J of Physical Organic Chem, 2024, 37
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Thermo-promoted annulation of arylboronic acids with anthranils under catalyst-free conditions: Access to acridines

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Journal of Chemical Research, 2024, 48
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Highly facilitated synthesis of phenyl(tetramethyl)acridinedione pharmaceuticals by a magnetized nanoscale catalytic system, constructed of GO, Fe3O4 and creatine

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Diamond and Related Materials, 2020, 102, 107661
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Ultrasound promoted montmorillonite K-10 catalyzed synthesis, characterization, molecular modelling, SAR and hypoglycemic studies of new rhodanine bejeweled acridine analogues

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Journal of Molecular Structure, 2021, 1242, 130828
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Experimental and computational thermochemical studies of acridone and N-methylacridone

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Recent Advances in Synthetic Pathways and Therapeutic Potential of Acridine and Acridone Derivatives

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Hantzsch reaction with bis-indole-2,3-diones: Synthesis of novel bis-spirocyclic oxindole incorporating acridine, dipyrazolo[3,4-b:4',3'-e]pyridine and pyrido[2,3-d:6,5-d']dipyrimidine

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An efficient Nano-Copper catalyzed base-free Knoevenagel condensation: A facile synthesis, molecular modelling simulations, SAR and hypoglycemic studies of new quinoline tethered acridine analogues as PPARγ agonists

Gangadhara Angajala, Valmiki Aruna and Radhakrishnan Subashini

Journal of Molecular Structure, 2020, 1220, 128601
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Development of a synthetic route towards N4,N9-disubstituted 4,9-diaminoacridines: On the way to multi-stage antimalarials

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Tetrahedron Letters, 2019, 60, 1166
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Design concepts of half-sandwich organoruthenium anticancer agents based on bidentate bioactive ligands

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On the tumor cell growth limiting potential of newly synthesized acridine-1,8-dione derivatives

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Biochemical investigation of the tryptophan biosynthetic enzyme anthranilate phosphoribosyltransferase in plants

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Journal of Biological Chemistry, 2023, 299, 105197
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Enamine-Tautomerization-Driven Mannich Reaction of Alkylazaarenes with Aminals

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Synthesis and Biological Evaluation of Acridine/Acridone Analogs as Potential Anticancer Agents

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Formation of micropollutant decomposition by-products during oxidation processes supported by natural sunlight

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Preparation and characterization of Gum Arabic Schiff's bases based on 9-aminoacridine with in vitro evaluation of their antimicrobial and antitumor potentiality

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One-Pot Sequential Synthesis of Alkenylated Dihydroquinolinones and Hexahydroacridinones in Deep Eutectic Solvent Medium

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Synthesis of acridine, bisacridine and quinoline derivatives with 1,2-azolic, pyridine and ferrocene fragments. Vestsi Natsyyanal’nai akademii navuk Belarusi

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Synthesis of fluoro and trifluoromethyl substituents containing novel tetracyclic N-benzylated benzopiperazine fused acridone regioisomers using a greener solvent 2-MeTHF and their DFT studies

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Journal of Fluorine Chemistry, 2022, 257-258, 109989
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Synthesis of Novel fused Azo-linked acridine derivatives using GO-ZnO nanocomposite

Zeinab Jafarian, Mohammad Nikpassand, Afshin Pourahmad and Leila Zare Fekri

Journal of Molecular Structure, 2021, 1245, 131081
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Evaluation of microstructure, magnetic properties and catalytic application of Co2+ and Cr3+ doped Ni- Zn spinel ferrite

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Ferroelectrics, 2022, 598, 169
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Antimicrobial, Antibiofilm and Cytotoxicity Activity of a New Acridine Hyperbranched Polymer in Solution and on Cotton Fabric

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Revision of structures of acridone alkaloids from natural sources

Hung‐Yi Chen, Sio‐Hong Lam, Mei‐Lin Yang, Hsin‐Yi Hung, Po‐Chuen Shieh, Fu‐An Chen, Ping‐Chung Kuo and Tian‐Shung Wu

J Chinese Chemical Soc, 2021, 68, 669
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Recent Advances in QSAR, SAR, and Therapeutic Potentials of Acridine Derivatives: A Review

Ramandeep Singh, Jeewanjot Singh and Amandeep Kaur

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Novel series of N-acylhydrazone based on acridone: Synthesis, conformational and theoretical studies

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Room Temperature Phosphorescence vs Triplet–Triplet Annihilation in N-Substituted Acridone Solids

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New antibacterial hydrogels based on sodium alginate

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An Overview of Acridine Analogs: Pharmacological Significance and Recent Developments

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Multicomponent reactions through pristine and modified chitosans: current status and future prospects

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J IRAN CHEM SOC, 2022, 19, 2191
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Carprofen: a theoretical mechanistic study to investigate the impact of hydrophobic interactions of alkyl groups on modulation of COX-1/2 binding selectivity

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Copper‐catalyzed synthesis of N‐aryl acridones from 2‐amino benzophenones and aryl boronic acids via sequential double oxidative C–N coupling

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Applied Organom Chemis, 2020, 34
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Repurposing antiplasmodial leads for cancer: Exploring the antiproliferative effects of N-cinnamoyl-aminoacridines

Mélanie Fonte, Catarina Rôla, Sofia Santana, Miguel Prudêncio, Joana Almeida, Ricardo Ferraz, Cristina Prudêncio, Cátia Teixeira and Paula Gomes

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Antiproliferative Activity of the New Analogues of Acridine/Acridone With Oligopeptide Derivatives and Molecular Docking With EGFR and Src Kinase

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Journal of Peptide Science, 2026, 32
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Tandem Access to Acridones and their Fused Derivatives: [1+2+3] Annulation of Isocyanides with Unsaturated Carbonyls

Ling‐Juan Zhang, Wenhui Yang, Zhongyan Hu, Xian‐Ming Zhang and Xianxiu Xu

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Synthesis of Heteroatom‐Containing Organic Molecules via Intramolecular Cross‐Dehydrogenative Coupling

Aanchal Batra, Manjot Kaur, Pushpinder Singh and Kamal Nain Singh

Eur J Org Chem, 2025, 28
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Palladium-Mediated Site-Selective C–H Bond Activation and Arylation of 9(10H)-Acridinone and Mechanistic Investigation: Stoichiometric and Catalytic Approaches

Jean-Ho Chu, Jin Lee, Guan-Wei Liao, Lin-En Zeng, Chien-Wen Lin, Ching-Hung Cheng, Wen-Chieh Lin, Li-Ching Shen, Guo-Feng Chen, Rong Chang and Andrew C.-H. Sue

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Synthesis of Novel Biologically Active Proflavine Ureas Designed on the Basis of Predicted Entropy Changes

Ladislav Janovec, Eva Kovacova, Martina Semelakova, Monika Kvakova, Daniel Kupka, David Jager and Maria Kozurkova

Molecules, 2021, 26, 4860
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1H, 13C and 15N NMR of spiro acridines integrated with pyrrole scaffolds

Mária Vilková, Michal Šoral, Michal Bečka, Ivan Potočňák, Danica Sabolová, Tibor Béres, Michal Dušek and Ján Imrich

Magnetic Reson in Chemistry, 2020, 58, 204
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Energy-efficient copper-catalyzed synthesis of N-aryl anthranilic acids using concentrated solar radiation

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Experiments and Calculation on New N,N-bis-Tetrahydroacridines

Madalina-Marina Hrubaru, Constantin Draghici, Francis Aurelien Ngounoue Kamga, Elena Diacu, ThankGod C. Egemonye, Anthony C. Ekennia and Eleonora-Mihaela Ungureanu

Molecules, 2024, 29, 4082
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N‐Aryl Acridone Derivatives as Effective Catalysts for Energy Transfer Reactions

Francesco Calogero, Gaetano D'Onghia, Federica Fina, Zakaria Ziani, Luca Sensoli, Andrea Gualandi, Andrea Fermi, Paola Ceroni and Pier Giorgio Cozzi

Chemistry A European J, 2026
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Weakly Coordinating, Ketone‐Directed (η5‐Pentamethylcyclopentadienyl)cobalt(III)‐ and (η5‐Pentamethylcyclopentadienyl)rhodium(III)‐Catalyzed C−H Amidation of Arenes: A Route to Acridone Alkaloids

Sourav Sekhar Bera, Md Raja Sk and Modhu Sudan Maji

Chemistry A European J, 2019, 25, 1806
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Acridine/Acridone Derivatives as Catalytic Inhibitors of Topoisomerase I

Maria Kozurkova and Othman Salem

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Sustainable Access to Acridin-9-(10H)ones with an Embedded m-Terphenyl Moiety Based on a Three-Component Reaction

Damiano Rocchi, Jorge Gómez-Carpintero, Juan F. González and J. Carlos Menéndez

Molecules, 2020, 25, 5565
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Design, one-pot novel synthesis of substituted acridine derivatives: DFT, structural characterisation, ADME and anticancer DNA polymerase epsilon molecular docking studies

Prakash Jayavel, Ramachandran Rajamanickam, Nepolraj Amaladoss, Venkateswaramoorthi Ramasamy and Vasyl I. Shupeniuk

Molecular Physics, 2024, 122
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Anti‐Proliferative and Apoptotic Evaluation of a Novel Synthesized Acridine Hybrid With Anticipated Synergistic Effect to Paclitaxel on Breast Cancer Cells

Esraa A. Aidy, Elshaymaa I. Elmongy, Abdullah A. S. Ahmed, Ibrahim El Tantawy El Sayed, Hanan Ali Henidi, Saad M. EL‐Gendy, Yasmin S. EL‐Gendy, Ahmed Ibrahim El‐Tantawy and Heba Effat

Chem Biol Drug Des, 2026, 107
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Intramolecular cross‐dehydrogenative coupling of benzaldehyde derivatives: A novel and efficient route to benzocyclic ketones

Jun Chen and Fatima Rashid Sheykhahmad

J Chinese Chemical Soc, 2020, 67, 638
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Acridones as promising drug candidates against Oropouche virus

Marielena Vogel Saivish, Gabriela de Lima Menezes, Roosevelt Alves da Silva, Leticia Ribeiro de Assis, Igor da Silva Teixeira, Umberto Laino Fulco, Clarita Maria Secco Avilla, Raphael Josef Eberle, Igor de Andrade Santos, Karolina Korostov, Mayara Lucia Webber, Gislaine Celestino Dutra da Silva, Maurício Lacerda Nogueira, Ana Carolina Gomes Jardim, Luis Octavio Regasin, Mônika Aparecida Coronado and Carolina Colombelli Pacca

Current Research in Microbial Sciences, 2024, 6, 100217
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Design, Synthesis and Evaluation of acridone-2-carbohydrazide Derivatives As p-AKT Ser 473 Kinase Inhibitors

Tanuja T Yadav, Maushmi S Kumar, Shalini Bajaj and Mayur YC

Future Med. Chem., 2023, 15, 699
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Emerging Insights and Innovations in Acridine Derivatives: A Review

Sakshi Gupta, Abhishek Tiwari, Nalini Kanta Sahoo and Varsha Tiwari

CBC, 2026, 22
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Synthesis, Structures, and Complexation with Phenolic Guests of Acridone‐Incorporated Arylene–Ethynylene Macrocyclic Compounds

Takashi Komori, Eiji Tsurumaki and Shinji Toyota

Chemistry An Asian Journal, 2023, 18
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Pyridine-Containing Benzocyclopentaquinolines and Benzacridines and Their Quaternary Salts

E. A. Dikusar, E. A. Akishina, S. S. Kovalskaya, M. S. Grigoriev, M. A. Fedoseeva, K. A. Alekseeva and V. I. Potkin

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Recent Advances in Biological Active Sulfonamide based Hybrid Compounds Part B: Two-Component Sulfonamide Hybrids

Shakila Ghomashi, Reihane Ghomashi, Hamidreza Aghaei and Ahmad Reza Massah

CMC, 2023, 30, 604
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Microporous and Hierarchical ZSM-5 Zeolites in Friedländer Synthesis

N. G. Grigor’eva, S. V. Bubennov, A. S. Artem’eva, D. V. Serebrennikov, N. A. Filippova and B. I. Kutepov

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Combing metabolomics with bioanalysis methods to study the antitumor mechanism of the new acridone derivative 8q on CCRF-CEM cells: 8q induced mitochondrial-mediated apoptosis and targeted the PI3K/AKT/FOXO1 pathway

Ning Wang, Bin Zhang, Feng Jin, Dan Gao, Feng Liu, Hongxia Liu and Yuyang Jiang

Journal of Pharmaceutical and Biomedical Analysis, 2018, 160, 314
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Synthesis, antibacterial evaluation, in silico ADMET and molecular docking studies of new N-acylhydrazone derivatives from acridone

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Arabian Journal of Chemistry, 2020, 13, 6236
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Design, synthesis and computational analysis of novel acridine-(sulfadiazine/sulfathiazole) hybrids as antibacterial agents

Miyase Gözde Gündüz, Muhammad Nawaz Tahir, Stevan Armaković, Ceren Özkul Koçak and Sanja J. Armaković

Journal of Molecular Structure, 2019, 1186, 39
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Toxicity and Antitumor Activity of a Thiophene–Acridine Hybrid

Thaís Lisboa, Daiana Silva, Sâmia Duarte, Rafael Ferreira, Camyla Andrade, Ana Luiza Lopes, Juliana Ribeiro, Davi Farias, Ricardo Moura, Malu Reis, Karina Medeiros, Hemerson Magalhães and Marianna Sobral

Molecules, 2019, 25, 64
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2-Aminobenzaldehyde, a common precursor to acridines and acridones endowed with bioactivities

Sarah Zeghada, Ghenia Bentabed-Ababsa, Olivier Mongin, William Erb, Laurent Picot, Valérie Thiéry, Thierry Roisnel, Vincent Dorcet and Florence Mongin

Tetrahedron, 2020, 76, 131435
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Synthesis and characterization of bentonite-based NiO nanoparticles as bi-functional heterogeneous catalyst for efficient synthesis of 1,8-dioxo-decahydroacridines

Ehsan Faryabi, Enayatollah Sheikhhosseini and Mahdieh Yahyazadehfar

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A review of 9, 9-Dimethyl-9, 10-dihydroacridine (DMAC) derivatives as thermally activated delayed fluorescence emitters in OLED applications

Masoud Dehghanipour and Zahra Nasresfahani

Journal of Molecular Structure, 2026, 1360, 145590
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The need for a consistent approach to account for transformation products when deriving environmental quality standards under the European Water Framework Directive

Lucy Kennelly, Graham Merrington, Dean Leverett, Rhiannon Smith and Sylwia Kosmala-Grzechnik

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Development and validation of a high-performance thin-layer chromatography densitometric method for the simultaneous determination of novel 1-acridinyl-1,2,3-triazole derivatives

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Scandium(III) Triflate-Catalyzed Reaction of Aroyl-Substituted Donor–Acceptor Cyclopropanes with 1-Naphthylamines: Access to Dibenzo[c,h]acridines

Murugesan Thangamani and Kannupal Srinivasan

J. Org. Chem., 2021, 86, 1172
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Direct Synthesis of 2‐Acyl Acridines Using Aldimines and Anthranils: Evaluation of Cytotoxicity and Anti‐Inflammatory Activity

Saegun Kim, Amit Kundu, Rina Chun, Sang Hoon Han, Ashok Kumar Pandey, Sungin Yoo, Junghyun Park, Hyung Sik Kim, Jin‐Mo Ku and In Su Kim

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Solvent-Free Synthesis, Characterization, and In Vitro Biological Activity Study of Xanthenediones and Acridinediones

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Highly Efficient Bimetallic Catalyst for the Synthesis of N-substituted Decahydroacridine-1,8-diones and Xanthene-1,8-diones: Evaluation of their Biological Activity

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One‐pot synthesis of tunable fluorescent polyethylene glycol (PEG) polymer for antimicrobial and anticancer theranostics

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10-(4-Phenylpiperazine-1-carbonyl)acridin-9(10H)-ones and related compounds: Synthesis, antiproliferative activity and inhibition of tubulin polymerization

Jana Waltemate, Igor Ivanov, Jahan B. Ghasemi, Elham Aghaee, Constantin Gabriel Daniliuc, Klaus Müller and Helge Prinz

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In Vitro and In Silico Antifouling Activity Analysis of Secondary Metabolites Extracted from the Marine Bacterium Vibrio alginolyticus

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Newly synthesized acridone derivatives targeting lung cancer: A toxicity and xenograft model study

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Synthesis and Antibacterial Activity of 9-Oxo-9,10-dihydroacridinecarboxylic Acids Esters Bearing a Triazole Fragment

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Base-Promoted and Copper(I)-Catalyzed Tandem Cyclization-C(sp2)-N Coupling of Vinyl Malononitriles with Ortho-Nitrochalcones: Access to Acridones and their Fused Derivatives

Raju L. Dhakar, S Banuprakash Goud and Sampak Samanta

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Acridine-Based Antimalarials—From the Very First Synthetic Antimalarial to Recent Developments

Mélanie Fonte, Natália Tassi, Paula Gomes and Cátia Teixeira

Molecules, 2021, 26, 600
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Application of the Povarov Reaction in Biaryls under Iron Catalysis for the General Synthesis of Dibenzo[a,c]Acridines

Baitan Chakraborty, Abhishek Kar, Rupsa Chanda and Umasish Jana

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Development of Mild Palladium‐Catalyzed N‐Arylation of Ortho‐Acylanilines in Rhamnolipid Micellar System

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ChemSusChem, 2026, 19
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Design, Synthesis and Evaluation of Photophysical and Biological Properties of Tetrafluoroacridine

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Major Achievements in the Design of Quadruplex-Interactive Small Molecules

Eduarda Mendes, Israa M. Aljnadi, Bárbara Bahls, Bruno L. Victor and Alexandra Paulo

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