Reconceptualising mucoadhesion for future medicines

Michael T. Cook and David Shorthouse

RSC Pharm., 2024, 1, 949
DOI: 10.1039/D4PM00149D

Exploring the potential of linear polymer structures for the synthesis of fluorescent gold nanoclusters

Nik Nik M. Adnan, Syafiq Ahmad, Rhiannon P. Kuchel and Cyrille Boyer

Mater. Chem. Front., 2017, 1, 80
DOI: 10.1039/C6QM00109B

Maleimide-bearing nanogels as novel mucoadhesive materials for drug delivery

Prasopchai Tonglairoum, Ruairí P. Brannigan, Praneet Opanasopit and Vitaliy V. Khutoryanskiy

J. Mater. Chem. B, 2016, 4, 6581
DOI: 10.1039/C6TB02124G

Microgel core/shell architectures as targeted agents for fibrinolysis

Purva Kodlekere and L. Andrew Lyon

Biomater. Sci., 2018, 6, 2054
DOI: 10.1039/C8BM00119G

NIR-II-triggered doxorubicin release for orthotopic bladder cancer chemo-photothermal therapy

Zhiduo Sun, Weiyun Zhang, Zhichao Ye, Li Yuan, Manli Fu, Xiaoming Liu, Huageng Liang and Heyou Han

Nanoscale, 2022, 14, 17929
DOI: 10.1039/D2NR04200B

Current status of the development of intravesical drug delivery systems for the treatment of bladder cancer

Ho Yub Yoon, Hee Mang Yang, Chang Hyun Kim, Yoon Tae Goo, Myung Joo Kang, Sangkil Lee and Young Wook Choi

Expert Opinion on Drug Delivery, 2020, 17, 1555
DOI: 10.1080/17425247.2020.1810016

Mucin immobilization in calcium alginate: A possible mucus mimetic tool for evaluating mucoadhesion and retention of flavour

Vlad Dinu, Gleb E. Yakubov, Mui Lim, Katherine Hurst, Gary G. Adams, Stephen E. Harding and Ian D. Fisk

International Journal of Biological Macromolecules, 2019, 138, 831
DOI: 10.1016/j.ijbiomac.2019.07.148

Advances in intravesical drug delivery systems to treat bladder cancer

Oluwadamilola M. Kolawole, Wing Man Lau, Hugh Mostafid and Vitaliy V. Khutoryanskiy

International Journal of Pharmaceutics, 2017, 532, 105
DOI: 10.1016/j.ijpharm.2017.08.120

Polymeric gels for intravaginal drug delivery

Michael T. Cook and Marc B. Brown

Journal of Controlled Release, 2018, 270, 145
DOI: 10.1016/j.jconrel.2017.12.004

Calcium carbonate in drug delivery: functional carrier design, applications, and data-driven perspectives

Saba Taheri, Dmitry V. Volodkin, Andre G. Skirtach and Bogdan V. Parakhonskiy

Expert Opinion on Drug Delivery, 2026, 23, 393
DOI: 10.1080/17425247.2025.2587907

Eudragit® EPO, modified with 4-phenylboronic acid groups, as a novel polymeric excipient with enhanced mucoadhesive properties

D. S. Gordeeva, S. F. Nasibullin, A. G. Karpov, V. V. Khutoryanskiy and R. I. Moustafine

Razrabotka i registraciâ lekarstvennyh sredstv, 2024
DOI: 10.33380/2305-2066-2024-13-3-1866

Adhesive mechanisms of mucoadhesive hydrogels for intravesical drug delivery

Peinan Yin, Peng Qu, Chengwei Wu and Wei Zhang

European Polymer Journal, 2025, 241, 114404
DOI: 10.1016/j.eurpolymj.2025.114404

A Review of Xyloglucan: Self-Aggregation, Hydrogel Formation, Mucoadhesion and Uses in Medical Devices

J. Esquena-Moret

Macromol, 2022, 2, 562
DOI: 10.3390/macromol2040037

Synthesis and evaluation of mucoadhesive acryloyl-quaternized PDMAEMA nanogels for ocular drug delivery

Ruairí P. Brannigan and Vitaliy V. Khutoryanskiy

Colloids and Surfaces B: Biointerfaces, 2017, 155, 538
DOI: 10.1016/j.colsurfb.2017.04.050

Local Drug Delivery in Bladder Cancer: Advances of Nano/Micro/Macro-Scale Drug Delivery Systems

Irina Marchenko and Daria Trushina

Pharmaceutics, 2023, 15, 2724
DOI: 10.3390/pharmaceutics15122724

A mucosa-mimetic material for the mucoadhesion testing of thermogelling semi-solids

Jéssica Bassi da Silva, Vitaliy V. Khutoryanskiy, Marcos L. Bruschi and Michael T. Cook

International Journal of Pharmaceutics, 2017, 528, 586
DOI: 10.1016/j.ijpharm.2017.06.025

An enzymatically controlled mucoadhesive system for enhancing flavour during food oral processing

Vlad Dinu, Arthur Gadon, Katherine Hurst, Mui Lim, Charfedinne Ayed, Richard B. Gillis, Gary G. Adams, Stephen E. Harding and Ian D. Fisk

npj Sci Food, 2019, 3
DOI: 10.1038/s41538-019-0043-y

Potential bladder cancer therapeutic delivery systems: a recent update

Oluwadamilola M. Kolawole and Vitaliy V. Khutoryanskiy

Expert Opinion on Drug Delivery, 2024, 21, 1311
DOI: 10.1080/17425247.2024.2396958

Protected thiol strategies in macromolecular design

Fabienne Goethals, Daniel Frank and Filip Du Prez

Progress in Polymer Science, 2017, 64, 76
DOI: 10.1016/j.progpolymsci.2016.09.003

Catechol-Functionalized Alginate Nanoparticles as Mucoadhesive Carriers for Intravesical Chemotherapy

Nitjawan Sahatsapan, Tanasait Ngawhirunpat, Theerasak Rojanarata, Praneet Opanasopit and Prasopchai Patrojanasophon

AAPS PharmSciTech, 2020, 21
DOI: 10.1208/s12249-020-01752-7

Thiolated poly(2-hydroxyethyl methacrylate) hydrogels as a degradable biocompatible scaffold for tissue engineering

Hana Macková, Helena Hlídková, Zhansaya Kaberova, Vladimír Proks, Jan Kučka, Vitalii Patsula, Miroslav Vetrik, Olga Janoušková, Bohumila Podhorská, Ognen Pop-Georgievski, Šárka Kubinová and Daniel Horák

Materials Science and Engineering: C, 2021, 131, 112500
DOI: 10.1016/j.msec.2021.112500

Mucoadhesion and mucosa-mimetic materials—A mini-review

Michael T. Cook and Vitaliy V. Khutoryanskiy

International Journal of Pharmaceutics, 2015, 495, 991
DOI: 10.1016/j.ijpharm.2015.09.064

Mucoadhesive Thiolated Hyaluronic Acid/Pluronic F127 Nanogel Formation via Thiol–Maleimide Click Reaction for Intravesical Drug Delivery

Fayang Li, Xianhuang Chen, Yuanqiao He and Zhiping Peng

ACS Appl. Bio Mater., 2024, 7, 1976
DOI: 10.1021/acsabm.4c00068

Beyond PEGylation: Alternative surface-modification of nanoparticles with mucus-inert biomaterials

Vitaliy V. Khutoryanskiy

Advanced Drug Delivery Reviews, 2018, 124, 140
DOI: 10.1016/j.addr.2017.07.015

Acrylated Eudragit® E PO as a novel polymeric excipient with enhanced mucoadhesive properties for application in nasal drug delivery

Natalia N. Porfiryeva, Shamil F. Nasibullin, Svetlana G. Abdullina, Irina K. Tukhbatullina, Rouslan I. Moustafine and Vitaliy V. Khutoryanskiy

International Journal of Pharmaceutics, 2019, 562, 241
DOI: 10.1016/j.ijpharm.2019.03.027

Doxorubicin-loaded chitosan-alginate nanoparticles with dual mucoadhesive functionalities for intravesical chemotherapy

Nitjawan Sahatsapan, Theerasak Rojanarata, Tanasait Ngawhirunpat, Praneet Opanasopit and Prasopchai Patrojanasophon

Journal of Drug Delivery Science and Technology, 2021, 63, 102481
DOI: 10.1016/j.jddst.2021.102481

2-Hydroxyethyl methacrylate based polymer microgels and their hybrids

Ghulam Mustafa, Ahmad Hassan, Muhammad Shahid, Ahmad Irfan, Aijaz Rasool Chaudhry, Zahoor H. Farooqi and Robina Begum

Reactive and Functional Polymers, 2024, 200, 105919
DOI: 10.1016/j.reactfunctpolym.2024.105919

Feasibility of mucoadhesive chitosan maleimide-coated liposomes for improved buccal delivery of a protein drug

Nitjawan Sahatsapan, Boonnada Pamornpathomkul, Theerasak Rojanarata, Tanasait Ngawhirunpat, Raksawan Poonkhum, Praneet Opanasopit and Prasopchai Patrojanasophon

Journal of Drug Delivery Science and Technology, 2022, 69, 103173
DOI: 10.1016/j.jddst.2022.103173

Synthesis of thiolated, PEGylated and POZylated silica nanoparticles and evaluation of their retention on rat intestinal mucosa in vitro

Twana Mohammed M. Ways, Wing Man Lau, Keng Wooi Ng and Vitaliy V. Khutoryanskiy

European Journal of Pharmaceutical Sciences, 2018, 122, 230
DOI: 10.1016/j.ejps.2018.06.032

The progress on sulfhydryl modified polymers with regard to synthesis, characterization and mucoadhesion

Eva Sanchez Armengol and Flavia Laffleur

International Journal of Pharmaceutics, 2021, 592, 120016
DOI: 10.1016/j.ijpharm.2020.120016

Thiolated polymers: Bioinspired polymers utilizing one of the most important bridging structures in nature

Christina Leichner, Max Jelkmann and Andreas Bernkop-Schnürch

Advanced Drug Delivery Reviews, 2019, 151-152, 191
DOI: 10.1016/j.addr.2019.04.007

Spray-dried mucoadhesives for intravesical drug delivery using N-acetylcysteine- and glutathione-glycol chitosan conjugates

Nunzio Denora, Angela Lopedota, Mara Perrone, Valentino Laquintana, Rosa M. Iacobazzi, Antonella Milella, Elisabetta Fanizza, Nicoletta Depalo, Annalisa Cutrignelli, Antonio Lopalco and Massimo Franco

Acta Biomaterialia, 2016, 43, 170
DOI: 10.1016/j.actbio.2016.07.025

Chitosan and its Derivatives for Ocular Delivery Formulations: Recent Advances and Developments

Alexandra Zamboulis, Stavroula Nanaki, Georgia Michailidou, Ioanna Koumentakou, Maria Lazaridou, Nina Maria Ainali, Eleftheria Xanthopoulou and Dimitrios N. Bikiaris

Polymers, 2020, 12, 1519
DOI: 10.3390/polym12071519

Chitosan/polyvinyl alcohol-based magnetic hydrogel microspheres with controlled retention and regulated drug release for intravesical instillation

Peinan Yin, Chengxiong Wei, Anamaria Brozovic, Chengwei Wu and Wei Zhang

International Journal of Biological Macromolecules, 2025, 287, 138412
DOI: 10.1016/j.ijbiomac.2024.138412

Mechanisms and strategies to enhance penetration during intravesical drug therapy for bladder cancer

Pu Zhang, Guoqing Wu, Dahong Zhang and Wing-Fu Lai

Journal of Controlled Release, 2023, 354, 69
DOI: 10.1016/j.jconrel.2023.01.001

Progress and Current Trends in the Synthesis of Novel Polymers with Enhanced Mucoadhesive Properties

Ruairí P. Brannigan and Vitaliy V. Khutoryanskiy

Macromolecular Bioscience, 2019, 19
DOI: 10.1002/mabi.201900194

Mucoadhesive maleimide-functionalised liposomes for drug delivery to urinary bladder

Daulet B. Kaldybekov, Prasopchai Tonglairoum, Praneet Opanasopit and Vitaliy V. Khutoryanskiy

European Journal of Pharmaceutical Sciences, 2018, 111, 83
DOI: 10.1016/j.ejps.2017.09.039

Therapeutic vitamin delivery: Chemical and physical methods with future directions

N. Sanoj Rejinold, Hye Kyoung Kim, Abdel F. Isakovic, Deborah L. Gater and Yeu-Chun Kim

Journal of Controlled Release, 2019, 298, 83
DOI: 10.1016/j.jconrel.2019.01.038