Spiers Memorial Lecture: Mechanochemistry, tribochemistry, mechanical alloying – retrospect, achievements and challenges

Elena Boldyreva

Faraday Discuss., 2023, 241, 9
DOI: 10.1039/D2FD00149G

Ball-free mechanochemistry: in situ real-time monitoring of pharmaceutical co-crystal formation by resonant acoustic mixing

Adam A. L. Michalchuk, Karl S. Hope, Stuart R. Kennedy, Maria V. Blanco, Elena V. Boldyreva and Colin R. Pulham

Chem. Commun., 2018, 54, 4033
DOI: 10.1039/C8CC02187B

Bis(paracetamol) pyridine – a new elusive paracetamol solvate: from modeling the phase diagram to successful single-crystal growth and structure–property relations

Boris A. Zakharov, Andrey G. Ogienko, Alexander S. Yunoshev, Alexey I. Ancharov and Elena V. Boldyreva

CrystEngComm, 2015, 17, 7543
DOI: 10.1039/C5CE01213A

Inadvertent liquid assisted grinding: a key to “dry” organic mechano-co-crystallisation?

I. A. Tumanov, A. A. L. Michalchuk, A. A. Politov, E. V. Boldyreva and V. V. Boldyrev

CrystEngComm, 2017, 19, 2830
DOI: 10.1039/C7CE00517B

More than “just a drop”: the enigmatic role of liquid additives in mechanochemistry

Ilenia D'Abbrunzo and Dritan Hasa

CrystEngComm, 2026, 28, 1752
DOI: 10.1039/D5CE00778J

Mechanochemical reactions studied by in situ Raman spectroscopy: base catalysis in liquid-assisted grinding

Martina Tireli, Marina Juribašić Kulcsár, Nikola Cindro, Davor Gracin, Nikola Biliškov, Mladen Borovina, Manda Ćurić, Ivan Halasz and Krunoslav Užarević

Chem. Commun., 2015, 51, 8058
DOI: 10.1039/C5CC01915J

Ball size or ball mass – what matters in organic mechanochemical synthesis?

Adam A. L. Michalchuk, Ivan A. Tumanov and Elena V. Boldyreva

CrystEngComm, 2019, 21, 2174
DOI: 10.1039/C8CE02109K

A salt or a co-crystal – when crystallization protocol matters

E. A. Losev and E. V. Boldyreva

CrystEngComm, 2018, 20, 2299
DOI: 10.1039/C7CE02204B

Mechanochemical synthesis of (hetero)aryl Au(i) complexes

Fredric J. L. Ingner, Zachary X. Giustra, Sebastian Novosedlik, Andreas Orthaber, Paul J. Gates, Christine Dyrager and Lukasz T. Pilarski

Green Chem., 2020, 22, 5648
DOI: 10.1039/D0GC02263B

To touch or not to touch? Fingerprint-assisted grinding of carbamazepine form III

Daria Zheltikova, Evgeniy Losev and Elena Boldyreva

CrystEngComm, 2023, 25, 4879
DOI: 10.1039/D3CE00544E

Mechanochemical Synthesis of Ca- and Mg-Double Salt Crystalline Materials Using Insoluble Alkaline Earth Metal Bearing Minerals

Lohit Sharma, Daniyal Kiani, Kenneth Honer and Jonas Baltrusaitis

ACS Sustainable Chem. Eng., 2019, 7, 6802
DOI: 10.1021/acssuschemeng.8b06129

Tandem In Situ Monitoring for Quantitative Assessment of Mechanochemical Reactions Involving Structurally Unknown Phases

Stipe Lukin, Tomislav Stolar, Martina Tireli, Maria Valeria Blanco, Darko Babić, Tomislav Friščić, Krunoslav Užarević and Ivan Halasz

Chemistry A European J, 2017, 23, 13941
DOI: 10.1002/chem.201702489

Exploring the Effect of Temperature on a Mechanochemical Reaction by in Situ Synchrotron Powder X-ray Diffraction

Krunoslav Užarević, Vjekoslav Štrukil, Cristina Mottillo, Patrick A. Julien, Andreas Puškarić, Tomislav Friščić and Ivan Halasz

Crystal Growth & Design, 2016, 16, 2342
DOI: 10.1021/acs.cgd.6b00137

Thermal and in Situ X-ray Diffraction Analysis of a Dimorphic Co-Crystal, 1:1 Caffeine–Glutaric Acid

Venu R. Vangala, Pui Shan Chow, Martin Schreyer, Grace Lau and Reginald B. H. Tan

Crystal Growth & Design, 2016, 16, 578
DOI: 10.1021/acs.cgd.5b00798

Solid Forms of Ciprofloxacin Salicylate: Polymorphism, Formation Pathways, and Thermodynamic Stability

Artem O. Surov, Nikita A. Vasilev, Andrei V. Churakov, Julia Stroh, Franziska Emmerling and German L. Perlovich

Crystal Growth & Design, 2019, 19, 2979
DOI: 10.1021/acs.cgd.9b00185

Amorphization of itraconazole by inorganic pharmaceutical excipients: comparison of excipients and processing methods

Pawel Grobelny, Irina Kazakevich, Dan Zhang and Robin Bogner

Pharmaceutical Development and Technology, 2015, 20, 118
DOI: 10.3109/10837450.2014.959181

Reactive Mechanosynthesis of Urea Ionic Cocrystal Fertilizer Materials from Abundant Low Solubility Magnesium- and Calcium-Containing Minerals

Kenneth Honer, Carlos Pico and Jonas Baltrusaitis

ACS Sustainable Chem. Eng., 2018, 6, 4680
DOI: 10.1021/acssuschemeng.7b03766

Crucial Role of Water in the Mechanosynthesis of CsPbI3 and Other ABX3 Halides

Dmitry Tsvetkov, Maksim Mazurin, Ivan Ivanov, Dmitry Malyshkin, Vladimir Sereda and Andrey Zuev

Chemistry A European J, 2020, 26, 12549
DOI: 10.1002/chem.202003067

Mechanochemical solid acid/base reactions for obtaining biologically active preparations and extracting plant materials

Oleg I. Lomovsky, Igor O. Lomovskiy and Denis V. Orlov

Green Chemistry Letters and Reviews, 2017, 10, 171
DOI: 10.1080/17518253.2017.1339832

Isotope Labeling Reveals Fast Atomic and Molecular Exchange in Mechanochemical Milling Reactions

Stipe Lukin, Martina Tireli, Tomislav Stolar, Dajana Barišić, Maria Valeria Blanco, Marco di Michiel, Krunoslav Užarević and Ivan Halasz

J. Am. Chem. Soc., 2019, 141, 1212
DOI: 10.1021/jacs.8b12149

An algorithm to identify the existence and reproducibly obtain single crystals of salts and mixed crystals of amino acids suitable for single crystal XRD and Raman spectroscopy experiments

S. G. Arkhipov and E. V. Boldyreva

J Struct Chem, 2014, 55, 744
DOI: 10.1134/S0022476614040246

Ball Milling to Build the Hybrid Mesocrystals of Ibuprofen and Aragonite

Kyoung A Cho, Insil Choi, Il Won Kim and Xinqing Chen

Journal of Nanomaterials, 2015, 2015
DOI: 10.1155/2015/163190

ИНГИБИРОВАНИЕ РЕАКЦИИ ОРГАНИЧЕСКОГО МЕХАНОХИМИЧЕСКОГО СИНТЕЗА ПАРАМИ ВОДЫ, "Доклады Академии наук"

И.А. Туманов, А. А. Л. Михальчук, А. А. Политов, Е.В. Болдырева and В.В. Болдырев

Докл. РАН, 2017, 292
DOI: 10.7868/S0869565217030124

Using Desmotropes, Cocrystals, and Salts to Manipulate Reactivity in Mechanochemical Organic Reactions

Magdalena Kralj, Stipe Lukin, Goran Miletić and Ivan Halasz

J. Org. Chem., 2021, 86, 14160
DOI: 10.1021/acs.joc.1c01817

Time‐Resolved In Situ Monitoring of Mechanochemical Reactions

Adam A. L. Michalchuk and Franziska Emmerling

Angew Chem Int Ed, 2022, 61
DOI: 10.1002/anie.202117270

Toward Mechanistic Understanding of Mechanochemical Reactions Using Real-Time In Situ Monitoring

Stipe Lukin, Luzia S. Germann, Tomislav Friščić and Ivan Halasz

Acc. Chem. Res., 2022, 55, 1262
DOI: 10.1021/acs.accounts.2c00062

Inhibition of organic mechanochemical synthesis by water vapor

I. A. Tumanov, A. A. L. Michalchuk, A. A. Politov, E. V. Boldyreva and V. V. Boldyrev

Dokl Chem, 2017, 472, 17
DOI: 10.1134/S0012500817010050

Scale-Up of Agrochemical Urea-Gypsum Cocrystal Synthesis Using Thermally Controlled Mechanochemistry

Ivana Brekalo, Valentina Martinez, Bahar Karadeniz, Patrik Orešković, Donata Drapanauskaite, Hein Vriesema, Robert Stenekes, Martin Etter, Igor Dejanović, Jonas Baltrusaitis and Krunoslav Užarević

ACS Sustainable Chem. Eng., 2022, 10, 6743
DOI: 10.1021/acssuschemeng.2c00914

Challenges of Mechanochemistry: Is In Situ Real‐Time Quantitative Phase Analysis Always Reliable? A Case Study of Organic Salt Formation

Adam A. L. Michalchuk, Ivan A. Tumanov, Sumit Konar, Simon A. J. Kimber, Colin R. Pulham and Elena V. Boldyreva

Advanced Science, 2017, 4
DOI: 10.1002/advs.201700132

Drug–Excipient Interactions in the Solid State: The Role of Different Stress Factors

Corinna Gressl, Michael Brunsteiner, Adrian Davis, Margaret Landis, Klimentina Pencheva, Garry Scrivens, Gregory W. Sluggett, Geoffrey P. F. Wood, Heidrun Gruber-Woelfler, Johannes G. Khinast and Amrit Paudel

Mol. Pharmaceutics, 2017, 14, 4560
DOI: 10.1021/acs.molpharmaceut.7b00677

Tribochemistry, Mechanical Alloying, Mechanochemistry: What is in a Name?

Adam A. L. Michalchuk, Elena V. Boldyreva, Ana M. Belenguer, Franziska Emmerling and Vladimir V. Boldyrev

Front. Chem., 2021, 9
DOI: 10.3389/fchem.2021.685789

Screening for new pharmaceutical solid forms using mechanochemistry: A practical guide

Dritan Hasa and William Jones

Advanced Drug Delivery Reviews, 2017, 117, 147
DOI: 10.1016/j.addr.2017.05.001

Kinetics of the mechanochemical transformations in the “glycine - oxalic acid dihydrate” system revisited: The role of water

Evgeniy Losev, Polina Kalinina, Artem Golomolzin, Viktoria Kolesnikova and Elena Boldyreva

Front. Chem., 2025, 13
DOI: 10.3389/fchem.2025.1540129

In Situ Investigation of a Self-Accelerated Cocrystal Formation by Grinding Pyrazinamide with Oxalic Acid

Hannes Kulla, Sebastian Greiser, Sigrid Benemann, Klaus Rademann and Franziska Emmerling

Molecules, 2016, 21, 917
DOI: 10.3390/molecules21070917

Weak-Force Mechanocatalysis: Mechanoredox/Copper-Catalyzed Decarboxylative Cyclization/Coupling of Arylglycines

Qin Feng, Ruoyu Qin, Yingchun Ma, Tingfei Wang, Shiwei Zhang, Dandan Ge, Lou Shi and Deqiang Liang

ACS Catal., 2025, 15, 19850
DOI: 10.1021/acscatal.5c04799

Structure-forming units of amino acid maleates. Case study ofL-valinium hydrogen maleate

Denis Rychkov, Sergey Arkhipov and Elena Boldyreva

Acta Crystallogr B Struct Sci Cryst Eng Mater, 2016, 72, 160
DOI: 10.1107/S2052520615021022

Mechanochemistry: A Green Approach in the Preparation of Pharmaceutical Cocrystals

Mizraín Solares-Briones, Guadalupe Coyote-Dotor, José C. Páez-Franco, Miriam R. Zermeño-Ortega, Carmen Myriam de la O Contreras, Daniel Canseco-González, Alcives Avila-Sorrosa, David Morales-Morales and Juan M. Germán-Acacio

Pharmaceutics, 2021, 13, 790
DOI: 10.3390/pharmaceutics13060790

What Is Unique About Mechanochemical Reactions?

L. Takacs

Acta Phys. Pol. A, 2014, 126, 1040
DOI: 10.12693/APhysPolA.126.1040

Role of Mixing and Milling in Mechanochemical Synthesis (Review)

O. V. Lapshin, E. V. Boldyreva and V. V. Boldyrev

Russ. J. Inorg. Chem., 2021, 66, 433
DOI: 10.1134/S0036023621030116

Listening to the Formation of Polymorphs in a Ball Mill

Éloïse Marie Samantha Parlier, Kinann Al Amir, Thomas-Xavier Métro, Pierre Granjon, Danielle Laurencin and César Leroy

Anal. Chem., 2025, 97, 2922
DOI: 10.1021/acs.analchem.4c05608

Zeitaufgelöste In‐Situ‐Untersuchungen von mechanochemischen Reaktionen

Adam A. L. Michalchuk and Franziska Emmerling