Themed collection Biomaterials Science Emerging Investigators

This themed issue of Biomaterials Science highlights the work of emerging investigators in the field of biomaterials science. Editor-in-Chief Jennifer Elisseeff introduces the issue.

Printed nanofilms consisting of ultra-flexible polymer nanosheets and various inks mechanically conform to the living body and provide a range of biomedical applications.

This mini-review discusses progress in the synthesis of sequence-controlled polymers and highlights recent studies demonstrating sequence effects on biomaterial properties.

This review highlights the evolution of regenerative dental materials with a focus on acellular biomaterials for endodontic treatment.

Reviewing the various methods and effectivity to stabilize DNA origami in biological environments.

This Minireview summarizes recent advances in the controlled synthesis, assembly, and biomedical applications of ultra-small nanoclusters.

The use of nanomaterials as contrast agents for photoacoustic imaging in the NIR-II window enables enhanced imaging quality with deeper tissue penetration.

This paper has reviewed the recent advances in the development of CaP nanocarriers and their applications in tumor diagnosis, gene delivery, drug delivery and theranostics and finally discussed the perspectives.

The emergence of the CRISPR–Cas9 gene editing system has generated considerable hope and excitement in the field of gene therapy and the larger scientific community. Recently, biomaterials have become an attractive option for the delivery of Cas9 due to their remarkable versatility.

Targeted drug delivery is emerging as a promising strategy to achieve better clinical outcomes.

Biodegradable polyester urethane acrylate oligomers were created to address the scarcity of resins for Digital Light Processing (DLP). Cell adhesion was heavily influenced by copolymer composition.

Triggered release of small molecule model therapeutics from hydrogel biomaterials is governed by user-programmable Boolean logic.

A drug-loaded nanocarrier integrating the sustained drug release and improved lubrication ability is fabricated for the treatment of osteoarthritis.

A highly antimicrobial, biocompatible, and fast biodegradable polycarbonate has been developed by incorporating primary ammonium and monoether side chains.

Perfusion of channels embedded in large hydrogels creates opposing morphogen gradients, resulting in multi-differentiation of stem cells into a spectrum of cell fates.

Interleukin-2 (IL-2) is a potent T-cell mitogen that can adjuvant anti-cancer adoptive T-cell transfer (ACT) immunotherapy by promoting T-cell engraftment.

Soft, flexible and stretchable conductive elastomers made of polyurethane and PEDOT:PSS blends were fabricated into fully polymeric implantable bioelectrode arrays.

A CA4P and CDDP co-loaded polypeptide gel depot was prepared for enhanced local colon cancer treatment.

Biomimetic spidroin self-assembly allows formation of substrate-independent one-pot nanothin silk coatings.

PLPs increase fibrin stiffness, promote cell migration, and improve healing outcomes.

ADSCs encapsulated in biomimetic PEG hydrogels maintain stemness and secrete survival- and growth-promoting factors that support in vitro folliculogenesis.

Encapsulation within poly(ethylene glycol)-b-poly(propylene sulfide) micelles reduces the toxicity of celastrol and enhances its anti-inflammatory effect during treatment of atherosclerosis.

Macromolecular crowding of collagen I during polymerization produces short, degradation-resistant fibrils that induce collective morphogenesis of breast cancer cells.

A novel polymeric biomaterial platform with tunable functionalizability for extrusion-based 3D printing.

In this study, we compare the ability of two different degradable alginate hydrogel formulations to efficiently deliver LV and AAV. We propose that release rates of viral vectors are dependent on the physical properties of both the hydrogels and vectors.

Doxorubicin–paclitaxel prodrug nanoparticles with redox-responsive were synthesized to selectively inhibit cancer cells with reduced adverse drug effect to healthy cells.

Stimuli-responsive nanogels degrade to small molecules in reducing environments to mediate controlled drug release.

A pH-responsive hydrogel prepared by oxidized dextran with aminoglycoside and an ornidazole analogue can kill both aerobic and anaerobic pathogens.

We developed different classes of hydrogels, with conductive and non-conductive nanomaterials, to study cardiac tissue maturation and excitability.

Delivery of a 5′ triphosphate RNA (3pRNA), a ligand for RIG-I, with endosomolytic nanoparticles (NP) augments response to anti-PD1 immune checkpoint blockade.

A combinatorial library of cationic lipidoids were used as nanocarriers for intracellular delivery of the CRISPR/Cas9 ribonucleoprotein complex.