Regioselective electrochemical C–H sulfonylation–bromination between indolizines, sodium sulfinates, and KBr has been established in an undivided cell, in which KBr serves as both the brominating agent and electrolyte.
A new method for the synthesis of seven-membered heterocycle-fused indolizine scaffolds from 2-(1-alkynyl-cyclopropyl)pyridines and nitrones under the catalysis of PPh3AuNTf2.
We developed a protocol for synthesis of PDIZs from CMQZs with isocyanides. The cycloaddition of [1,4]/[1,6]/[1,2] and skeletal rearrangement were performed by heating a mixture of 1–2 in DMSO, which was promoted by Cs2CO3 and catalyzed by Ag2CO3.
This study introduces enantioselective indolizine alkylation with aminals via chiral phosphoric acid catalysis, featuring scalable, functional group-tolerant processes, enabling access to diverse C1/C3-alkylated indolizines.
Computational analysis reveals a boryl-radical-enabled cross-coupling pathway for synthesizing indolizines, emphasizing the role of H-shuttles in facilitating reactions.