Herein, we disclose the asymmetric total synthesis of 1′-deshydroxymethyl analogues of naturally occurring aporpinone A, aporpinone B, and 4′-hydroxyaporpinone A, featuring a γ-Z-alkylidene butenolide framework.
This review presents a comprehensive overview of recent advances in the discovery methodologies, new structures, bioactivities, and unique biosynthetic logics of myxobacterial natural products reported from January 2017 to November 2023.
Collective synthesis of geissolosimine, geissoschizoline, akuammicine, (16S)-deshydroxymethylstemmadenine and Aspidospermatan alkaloids was achieved based on a catalytic asymmetric double Michael addition.
A Cr(II)-mediated highly diastereoselective Nozaki–Hiyama allylation has been employed in the efficient first asymmetric total synthesis of two 1,10-seco-guaianolides.
3-Methylene isochromanones, chemically challenging to access, are achieved via a novel click-like o-QM platform utilizing fermentation-accessible HOI as a reactive linchpin, enabling versatile access to diverse bioactive analogs.