Trifluoromethylated lactams combine the CF3 group’s unique electronic properties with the biological potential of cyclic amides, offering opportunities for novel syntheses and exploration of their promising medical applications.
Here we report an unprecedented O-trifluoromethylation of ketones using chloro(phenyl)trifluoromethyl-λ3-iodane (CPTFI).
This review describes several key activation methods for Langlois' reagent in the difunctionalization of alkenes and could stimulate the interest of readers in promoting the wider development and application of Langlois' reagent.
Recent advances in the preparation of trifluoromethyl-containing heterocyclics via trifluoromethyl building block strategies over the period from 2019 to the present are systematically summarized and discussed.
A metal and oxidant free photoredox catalytic protocol for trifluoromethylation of indazole compounds was developed by using TT-CF3+OTf− as the trifluoromethylation reagent and ionic liquids as solvents.