A straightforward protocol for the synthesis of 3-fluoroallyl alcohols via fluorine-hydrogen bonding promoted gold catalyzed hydrofluorination using Et3N·3HF under acidic additive-free conditions has been developed.
The hydrofluorination of enynoates has been developed for the synthesis of fluorinated dienoates.
The review focuses on gold-catalyzed nucleophilic and electrophilic fluorination of alkynes and allenes to direct access the valuable fluoroalkanes, fluoroalkenes, α-fluorocarbonyls, and fluorinated carbo- and hetero-cycles.
A gold-catalyzed hydrofluorination of terminal alkynes using potassium bifluoride (KHF2) as a cheaper, safer, and water-free fluoride source, is reported.
A process to shuttle HF from a fluoroalkane to alkynes has been developed. The consecutive dehydrofluorination and hydrofluorination steps are catalysed by an amorphous zirconium chlorofluoride at room temperature.