Urvashi Patel, Joshua P. Smalley and James T. Hodgkinson
RSC Chem. Biol., 2023,4, 623-634
From themed collection:
Medicinal Chemistry Small Molecule Probes
Abstract
A review on current proteolysis targeting chimeras (PROTACs) as chemical probes for histone deacetylase (HDAC) enzymes.
Aya Fathy, Amro Allam, Ahmed K. ElHady, Dalia S. El-Gamil, Kai-Chun Lin, Yen-Hua Chang, Yu-Hsuan Lee, Sebastian Hilscher, Mike Schutkowski, Hany S. Ibrahim, Shun-Hua Chen, Chun-Hong Chen, Ashraf H. Abadi, Wolfgang Sippl, Po-Jen Chen, Yi-Sheng Cheng and Mohammad Abdel-Halim
RSC Med. Chem., 2025,16, 2754-2784
Abstract
Overexpression of histone deacetylase 6 (HDAC6) is implicated in tumorigenesis, invasion, migration, survival, apoptosis, and growth of various malignancies, making it a promising target for cancer treatment.
Yuquan Zhang and Yan Li
New J. Chem., 2024,48, 17915-17927
Abstract
Based on the dataset, classification models were constructed using various features and algorithms to identified dual JAK2 and HDAC6 inhibitors. To evaluate their activity, regression models were developed to predicted their pIC50.
Silas L. Wurnig, Maria Hanl, Thomas M. Geiger, Shiyang Zhai, Ina Dressel, Dominika E. Pieńkowska, Radosław P. Nowak and Finn K. Hansen
RSC Med. Chem., 2025,16, 2452-2459
From themed collection:
Induced-Proximity Pharmacology
Abstract
The first light-activatable photochemically targeting chimeras (PHOTACs) designed for the targeted degradation of histone deacetylase 6 are reported.
Yi-Chuang Xu, Hua Zheng, Xiao-Ying Tan, Christer Hogstrand, Tao Zhao, Xiao-Lei Wei and Zhi Luo
Environ. Sci.: Nano, 2024,11, 4240-4254
From themed collection:
HOT articles from Environmental Science: Nano
Abstract
Understanding the toxicity and hazard risk of various metal sources is very important and can provide new insights for their risk evaluation in the environment.