Overcoming biological inertness: multifaceted strategies to optimize PEEK bioactivity for interdisciplinary clinical applications

Yingjia Sun, Shixing Ma, Yang Shi, Mumian Chen, Yanhua Lan, Lingling Hu and Xiaofeng Yang

Biomater. Sci., 2025, 13, 3106
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Oxygen vacancy-containing hafnium-dioxide/polyetheretherketone composite with good photothermal performance and bioactivity for treatment of tumors and infection as well as the promotion of pro-osteogenesis

Yong Dai, Zhe Li, Xiaofeng Ji, Peng Cheng, Xingshi Yuan, Kerong Wu, Deqiang Wang, Jie Wei and Xifu Shang

J. Mater. Chem. B, 2025, 13, 5670
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Mussel-inspired self-assembly engineered implant coatings for synergistic anti-infection and osteogenesis acceleration

Mingyue Han, Zhiyun Dong, Jianshu Li, Jun Luo, Derong Yin, Lizhong Sun, Siying Tao, Li Zhen, Jiaojiao Yang and Jiyao Li

J. Mater. Chem. B, 2021, 9, 8501
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A Ti3C2 MXene-integrated near-infrared-responsive multifunctional porous scaffold for infected bone defect repair

Linli Zhang, Hui Zhang, Hongling Zhou, Yi Tan, Zhengmin Zhang, Wei Yang, Lixing Zhao and Zhihe Zhao

J. Mater. Chem. B, 2024, 12, 79
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Strategies to improve the performance of polyetheretherketone (PEEK) as orthopedic implants: from surface modification to addition of bioactive materials

Huagui Huang, Xin Liu, Jinzuo Wang, Moran Suo, Jing Zhang, Tianze Sun, Honghua Wang, Chengde Liu and Zhonghai Li

J. Mater. Chem. B, 2024, 12, 4533
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Chemically heparinized PEEK via a green method to immobilize bone morphogenetic protein-2 (BMP-2) for enhanced osteogenic activity

MeeiChyn Goh, Kiyoon Min, Young Ha Kim and Giyoong Tae

RSC Adv., 2024, 14, 1866
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A new opportunity for the preparation of PEEK-based bone implant materials: From SARA ATRP to photo-ATRP

Monika Flejszar, Paweł Chmielarz, Michael Gießl, Karol Wolski, Joanna Smenda, Szczepan Zapotoczny and Helmut Cölfen

Polymer, 2022, 242, 124587
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Treatment methods toward improving the anti-infection ability of poly(etheretherketone) implants for medical applications

Shuqi Zhang, Jiazhen Long, Lin Chen, Jie Zhang, Yunjian Fan, Jiayu Shi and Yuanjin Huang

Colloids and Surfaces B: Biointerfaces, 2022, 218, 112769
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Amyloid-Mediated Nanoarchitectonics with Biomimetic Mineralization of Polyetheretherketone for Enhanced Osseointegration

Yingtao Gao, Yanyun Pang, Shuo Wei, Qian Han, Shuting Miao, Min Li, Juanhua Tian, Chengyu Fu, Zhengge Wang, Xu Zhang, Peng Yang and Yongchun Liu

ACS Appl. Mater. Interfaces, 2023, 15, 10426
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Exploring the Antimicrobial Potential of LL-37 Derivatives: Recent Developments and Challenges

Yihao Yuan, Jiapeng Li, Guotao Wei, Ziyi Shen, Bo Li, Jiawei Wu and Jing Liu

ACS Biomater. Sci. Eng., 2025, 11, 3145
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Bioinspired synthetic peptide-based biomaterials regenerate bone through biomimicking of extracellular matrix

Sareh Azadi, Mohammad Ali Yazdanpanah, Ali Afshari, Niloofar Alahdad, Solmaz Chegeni, Abdolhamid Angaji, Seyed Mahdi Rezayat and Shima Tavakol

J Tissue Eng, 2024, 15
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Application of biomolecules modification strategies on PEEK and its composites for osteogenesis and antibacterial properties

Xiao Han, Weijia Gao, Zhe Zhou, Shihui Yang, Junyan Wang, Ruining Shi, Yongli Li, Junjie Jiao, Yuanzheng Qi and Jinghui Zhao

Colloids and Surfaces B: Biointerfaces, 2022, 215, 112492
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Application of Porous Polyetheretherketone Scaffold/Vancomycin‐Loaded Thermosensitive Hydrogel Composites for Antibacterial Therapy in Bone Repair

Desheng Qi, Ningning Wang, Yuanqiang Cheng, Yao Zhao, Lingcheng Meng, Xigui Yue, Peng She and Hang Gao

Macromolecular Bioscience, 2022, 22
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A pH-Responsive Polyetheretherketone Implant Modified with a Core–Shell Metal–Organic Framework to Promote Antibacterial and Osseointegration Abilities

Shiqing Ma, Shiyu Yao, Yumeng Li, Yilin Yang, Tianyi Tong, Hong Zheng, Beibei Ma, Pengfei Wei, Zhengyi Di, Bo Zhao and Jiayin Deng

Biomater Res, 2025, 29
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Evaluation of the Clinical Performance of NuSmile Pedodontics Zirconia Crowns in Pulp-Treated Primary Teeth—2 Years Follow-Up Study

Rana A. Alamoudi, Tarun Walia and Dina Debaybo

Eur J Dent, 2023, 17, 082
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Research and Application of Medical Polyetheretherketone as Bone Repair Material

Feifei Pu, Yihan Yu, Zhicai Zhang, Wei Wu, Zengwu Shao, Chao Li, Jing Feng, Longjian Xue and Fengxia Chen

Macromolecular Bioscience, 2023, 23
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Antimicrobial peptides for bone tissue engineering: Diversity, effects and applications

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Front. Bioeng. Biotechnol., 2022, 10
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Optimizing PEEK implant surfaces for improved stability and biocompatibility through sandblasting and the platinum coating approach

Afrah Faadhila, Mohamad Taufiqurrakhman, Puspita Anggraini Katili, Siti Fauziyah Rahman, Delly Chipta Lestari and Yudan Whulanza

Front. Mech. Eng., 2024, 10
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Current treatment methods to improve the bioactivity and bonding strength of PEEK for dental application: A systematic review

Tongtong Ma, Jiajia Zhang, Shuoyao Sun, Wenqing Meng, Yan Zhang and Junling Wu

European Polymer Journal, 2023, 183, 111757
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Preparation of BMP-2/PDA-BCP Bioceramic Scaffold by DLP 3D Printing and its Ability for Inducing Continuous Bone Formation

Ziyang Yang, Li Xie, Boqing Zhang, Gang Zhang, Fangjun Huo, Changchun Zhou, Xi Liang, Yujiang Fan, Weidong Tian and Yinghui Tan

Front. Bioeng. Biotechnol., 2022, 10
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Peptide-Based Biomaterials for Bone and Cartilage Regeneration

Kausik Kapat, Sakshi Kumbhakarn, Rahul Sable, Prashil Gondane, Shruti Takle and Pritiprasanna Maity

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Peek@ZIF-8(CEL) as a Novel Bone Implant for Large Defect Repair and Enhanced Bone Healing via a Long-Term Stable Bioactive Releaser

Yongmei Ge, Liqiu Hu, Jiayi Liu, Fenbo Ma, Jiarong Zhang, Yansong Wang, Bin Tang and Shuaishuai Cao

ACS Appl. Mater. Interfaces, 2024, 16, 44127
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A cross-linked coating loaded with antimicrobial peptides for corrosion control, early antibacterial, and sequential osteogenic promotion on a magnesium alloy as orthopedic implants

Hao Zhang, Peng Zhang, Xiaolong Shen, Jiaping Han, Haibo Wang, Haotian Qin, Binbin Wang, Junyu Qian, Anjaneyulu Udduttula, Rifang Luo, Kexin Zhao, Yunbing Wang and Yingqi Chen

Acta Biomaterialia, 2025, 193, 604
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Surface chemistry on PEEK surfaces: From enhanced biofunctionality to improved surface modifiability

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Applied Materials Today, 2024, 41, 102523
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Enhancing bioactivity and biocompatibility of polyetheretherketone (PEEK) for dental and maxillofacial implants: A novel sequential soaking process

Wenqing Meng, Yifei Nie, Jiajia Zhang, Ludan Qin, Xueye Liu, Tongtong Ma and Junling Wu

Heliyon, 2024, 10, e33381
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Unveiling the characteristics and surface modification of titanium, zirconia, and polyetheretherketone dental implants

Yu-Hsuan Cheng, Chun-Cheng Chen and Shinn-Jyh Ding

Journal of Dental Sciences, 2025, 20, 2046
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Mussel-Inspired Polydopamine-Based Multilayered Coatings for Enhanced Bone Formation

Hao Wu, Cancan Zhao, Kaili Lin and Xudong Wang

Front. Bioeng. Biotechnol., 2022, 10
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Modification strategies for improving antibacterial properties of polyetheretherketone

Weijia Gao, Xiao Han, Yongli Li, Zhe Zhou, Junyan Wang, Ruining Shi, Junjie Jiao, Yuanzheng Qi, Yanmin Zhou and Jinghui Zhao

J of Applied Polymer Sci, 2022, 139
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Study on the Antibacterial Activity and Bone Inductivity of Nanosilver/PLGA-Coated TI-CU Implants

Zhaoli Geng, Renping Dong, Xinlin Li, Xinyi Xu, Lin Chen, Xu Han, Dongxu Liu and Yi Liu

IJN, 2024, Volume 19, 6427
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Facilitating GL13K Peptide Grafting on Polyetheretherketone via 1-Ethyl-3-(3-dimethylaminopropyl)carbodiimide: Surface Properties and Antibacterial Activity

Chih-Chien Hu, Selvaraj Rajesh Kumar, Truong Thi Tuong Vi, Yu-Tzu Huang, Dave W. Chen and Shingjiang Jessie Lue

IJMS, 2021, 23, 359
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Rational integration of defense and repair synergy on PEEK osteoimplants via biomimetic peptide clicking strategy

Meng Li, Jiaxiang Bai, Huaqiang Tao, Li Hao, Weiling Yin, Xiaoxue Ren, Ang Gao, Ning Li, Miao Wang, Shiyuan Fang, Yaozeng Xu, Liang Chen, Huilin Yang, Huaiyu Wang, Guoqing Pan and Dechun Geng

Bioactive Materials, 2022, 8, 309
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Polyetheretherketone development in bone tissue engineering and orthopedic surgery

Zhanqi Wei, Ze Zhang, Wei Zhu and Xisheng Weng

Front. Bioeng. Biotechnol., 2023, 11
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Application of Antimicrobial Peptides on Biomedical Implants: Three Ways to Pursue Peptide Coatings

Marco G. Drexelius and Ines Neundorf

IJMS, 2021, 22, 13212
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High-strength porous polyetheretherketone/hydroxyapatite composite for the treatment of bone defect

Desheng Qi, Ningning Wang, Shan Wang, Lei Liu, Song Zhu, Peng She and Xigui Yue

Composites Communications, 2023, 38, 101473
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Research Progress of Antimicrobial Modification of Medical Polyetheretherketone

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ACM, 2024, 14, 4059
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Origami of KR-12 Designed Antimicrobial Peptides and Their Potential Applications

Jayaram Lakshmaiah Narayana, Abraham Fikru Mechesso, Imran Ibni Gani Rather, D. Zarena, Jinghui Luo, Jingwei Xie and Guangshun Wang

Antibiotics, 2024, 13, 816
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Antibacterial peptides-loaded bioactive materials for the treatment of bone infection

Gan Wang, Yutao Cui, He Liu, Yuhang Tian, Shaorong Li, Yi Fan, Shouye Sun, Dankai Wu and Chuangang Peng

Colloids and Surfaces B: Biointerfaces, 2023, 225, 113255
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Exposure to polydopamine nanoparticles induces neurotoxicity in the developing zebrafish

Mengqi Sun, Yuanyuan Cao, Qinglin Sun, Xiaoke Ren, Junjie Hu, Zhiwei Sun and Junchao Duan

NanoImpact, 2021, 24, 100353
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Sand casting-inspired surface modification of 3D-printed porous polyetheretherketone scaffolds for enhancing osteogenesis

Jingjie Yu, Yuhan Zhang, Jiabao Guo, Xinrui Shu, Qinqin Lu and Qiang Chen

Composites Part A: Applied Science and Manufacturing, 2024, 179, 108033
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Antimicrobial coating strategy to prevent orthopaedic device-related infections: recent advances and future perspectives

Huichao Wei, Xinyu Song, Pengyan Liu, Xiaohu Liu, Xuefeng Yan and Liangmin Yu

Biomaterials Advances, 2022, 135, 212739
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Methods to improve antibacterial properties of PEEK: A review

Idil Uysal, Ayşen Tezcaner and Zafer Evis

Biomed. Mater., 2024, 19, 022004
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ZnO nanoparticles attenuate polymer-wear-particle induced inflammatory osteolysis by regulating the MEK-ERK-COX-2 axis

Xiangchao Meng, Wei Zhang, Zhuocheng Lyu, Teng Long and You Wang

Journal of Orthopaedic Translation, 2022, 34, 1
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Construction of a BMP‐2 gene delivery system for polyetheretherketone bone implant material and its effect on bone formation in vitro

Shuang Qin, Zhengkuan Lu, Kang Gan, Chunyan Qiao, Baosheng Li, Tianjie Chen, Yunbo Gao, Lingling Jiang and Hong Liu

J Biomed Mater Res, 2022, 110, 2075
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Enhancing Titanium-Osteointegration: Antimicrobial, anti-inflammatory and osteogenic properties of multifunctional coatings through Layer-by-Layer Self-Assembly

Danyang Xu, Xiaofeng Wang, Meiyu Li, Lei Xie, Kunjie Liu, Yihan Liu, Jinping Lan, Pengde Han, He Lin, Lili Song, Xuejiao Zhang and Yong Huang

Applied Surface Science, 2025, 686, 162149
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Intraosseous Injection of Calcium Phosphate Polymer-Induced Liquid Precursor Increases Bone Density and Improves Early Implant Osseointegration in Ovariectomized Rats

Yanyan Zhou, Zihe Hu, Mingjie Ge, Wenjing Jin, Ruikang Tang, Qi Li, Weijian Xu, Jue Shi and Zhijian Xie

IJN, 2021, Volume 16, 6217
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Linearized teixobactin is inactive and after sequence enhancement, kills methicillin‐resistant Staphylococcus aureus via a different mechanism

Qianhui Wu, Biswajit Mishra and Guangshun Wang

Peptide Science, 2022, 114
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Strategies to improve bioactive and antibacterial properties of polyetheretherketone (PEEK) for use as orthopedic implants

Zhi Zheng, Pengjia Liu, Xingmin Zhang, Jingguo xin, Yongjie wang, Xiaosong Zou, Xiaohan Mei, Shuling Zhang and Shaokun Zhang

Materials Today Bio, 2022, 16, 100402
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Polydopamine-Based Biomaterials in Orthopedic Therapeutics: Properties, Applications, and Future Perspectives

Min Zhang, Man Mi, Zilong Hu, Lixian Li, Zhiping Chen, Xiang Gao, Di Liu, Bilian Xu and Yanzhi Liu

DDDT, 2024, Volume 18, 3765
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Development of high-strength porous polyetheretherketone foam/nanosilver antibacterial composites for the prevention of postoperative infections in bone repair

Desheng Qi, Shuang Zhao, Huaiyu Zhang, Bo Liu, Peng She and Xigui Yue

Composites Communications, 2022, 31, 101127
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Approaches to Biofunctionalize Polyetheretherketone for Antibacterial: A Review

Yihan Wang, Shutao Zhang, Bin’en Nie, Xinhua Qu and Bing Yue

Front. Bioeng. Biotechnol., 2022, 10
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Protecting Orthopaedic Implants from Infection: Antimicrobial Peptide Mel4 Is Non-Toxic to Bone Cells and Reduces Bacterial Colonisation When Bound to Plasma Ion-Implanted 3D-Printed PAEK Polymers

Hedi Verena Kruse, Sudip Chakraborty, Renxun Chen, Naresh Kumar, Muhammad Yasir, William T. Lewin, Natalka Suchowerska, Mark D. P. Willcox and David R. McKenzie

Cells, 2024, 13, 656
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CoFe2O4/MXene nanosheets modified hydrogel on PEEK with phototherapeutic and GPx-Mimetic activities for anti-pathogens in infectious bone defect repairment

Qiancun Wang, Chuanmei Zang, Yau Kei Chan, Song Wang, Weizhong Yang, Yi Deng, Tingting Zhu and Miaomiao He

Materials Chemistry and Physics, 2023, 308, 128269
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Research progress and future prospects of antimicrobial modified polyetheretherketone (PEEK) for the treatment of bone infections

Ziyi Zhang, Junxing Shao, Yu Gao, Yuhuan Li, Te Liu and Modi Yang

Front. Bioeng. Biotechnol., 2023, 11
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Tantalum oxide submicro-particles into microporous coating on polyimide possessing antibacterial property and inducing cellular response for orthopedic application

Syed Asadullah, Shiqi Mei, Kong Yang, Xinglong Hu, Fan Wang, Baoqing Yu, Zhaoying Wu and Jie Wei

Journal of the Mechanical Behavior of Biomedical Materials, 2021, 124, 104800
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Construction of dual-functional fusion peptides modified polyetheretherketone for synergistically promoting osseointegration

Rui Li, Zige Guo, Le Li, Yazhuo Ni, Qiquan Yan, Keying Chen, Bo Xu, Yaoyang Li, Mengzhen Cui, Fuli Liu, Kexin Chang, Bo Kou and Shiqing Ma

Applied Materials Today, 2025, 45, 102833
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Mussel-inspired dopamine-CuII coated polyetheretherketone surface with direct and immunomodulatory effect to facilitate osteogenesis, angiogenesis, and antibacterial ability

Zhuocheng Lyu, Yaochao Zhao, Shicheng Huo, Fan Wang, Xiangchao Meng, Zhiguo Yuan, Teng Long and You Wang

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Polydopamine-assisted immobilization of silk fibroin and its derived peptide on chemically oxidized titanium to enhance biological activity in vitro

Changzhen Xu, Yijing Xia, Lu Wang, Xiaoru Nan, Jiaxin Hou, Yanqin Guo, Kejing Meng, Jing Lian, Yufang Zhang, Feng Wu and Bin Zhao

International Journal of Biological Macromolecules, 2021, 185, 1022
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Poly(dopamine)-assisted Bioactive Coating on the Surface of Porous Poly (Ether Ether Ketone) to Promote Osteogenic Differentiation of rBMSC

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J. Wuhan Univ. Technol.-Mat. Sci. Edit., 2021, 36, 766
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Functionalization of titanium using KR-12 peptide: antibacterial and osteogenic properties

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Surface Innovations, 2025, 13, 128
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Chikusetsusaponin IVa improves osseointegration by inhibiting osteoblast ferroptosis via the GSK3β/NRF2/GPX4 pathway

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Biochemical Pharmacology, 2025, 242, 117227
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3D printed PLGA/MgO/PDA composite scaffold by low-temperature deposition manufacturing for bone tissue engineering applications

Liang Tan, Zhuofeng Ye, Weida Zhuang, Beini Mao, Hetong Li, Xiuwang Li, Jiachang Wu and Hongxun Sang

Regenerative Therapy, 2023, 24, 617
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Lithium‐Functionalized Sulfonated Polyetheretherketone with Dual Osteogenic‐Angiogenic Property: A One‐Step Bioactivation Strategy for Enhanced Implants Osseointegration

Linjun Yang, Zhuocheng Lyu, Xuhui Fan, Xu Zheng and You Wang

Adv Healthcare Materials, 2025
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Immobilization of KR-12 on a Titanium Alloy Surface Using Linking Arms Improves Antimicrobial Activity and Supports Osteoblast Cytocompatibility

Mohadeseh Zare, Laura Colomina Alfaro, Antonella Bandiera, Esra Cansever Mutlu, David Grossin, Fernando Albericio, Sarah A. Kuehne, Zubair Ahmed and Artemis Stamboulis

ACS Appl. Bio Mater., 2025, 8, 2899
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Enhancing cell adhesive and antibacterial activities of glass-fibre-reinforced polyetherketoneketone through Mg and Ag PIII

Xin Tan, Zhongyi Wang, Xin Yang, Ping Yu, Manlin Sun, Yuwei Zhao and Haiyang Yu

Regenerative Biomaterials, 2023, 10
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Plasma assisted fluorination of polyether ether ketone for stable antimicrobial performance

Xiaoxue Bai, Hao Qin, Jing Jie, Chunxiuli Li, Yunhe Zhang and Lei Song

Colloid and Interface Science Communications, 2024, 61, 100791
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Biopolymeric Coatings for Local Release of Therapeutics from Biomedical Implants

Sepehr Talebian, Bárbara Mendes, João Conniot, Syamak Farajikhah, Fariba Dehghani, Zhongyan Li, Diogo Bitoque, Gabriela Silva, Sina Naficy, João Conde and Gordon G. Wallace

Advanced Science, 2023, 10
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Strategies of Immobilizing BMP-2 with 3D-printed Scaffolds to Improve Osteogenesis

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Construction of a dual signal recognition electrochemical electrode for detection of vancomycin concentration in plasma

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