A kinetic study of thiol addition to N-phenylchloroacetamide

Sarah K. I. Watt, Janique G. Charlebois, Christopher N. Rowley and Jeffrey W. Keillor

Org. Biomol. Chem., 2023, 21, 4702
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Cysteine-reactive probes and their use in chemical proteomics

Dominic G. Hoch, Daniel Abegg and Alexander Adibekian

Chem. Commun., 2018, 54, 4501
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Clickable coupling of carboxylic acids and amines at room temperature mediated by SO2F2: a significant breakthrough for the construction of amides and peptide linkages

Shi-Meng Wang, Chuang Zhao, Xu Zhang and Hua-Li Qin

Org. Biomol. Chem., 2019, 17, 4087
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Vinyl sulfonamide synthesis for irreversible tethering via a novel α-selenoether protection strategy

Gregory B. Craven, Dominic P. Affron, Philip N. Raymond, David J. Mann and Alan Armstrong

Med. Chem. Commun., 2019, 10, 158
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Quantitative chemoproteomic profiling reveals multiple target interactions of spongiolactone derivatives in leukemia cells

M. H. Wright, Y. Tao, J. Drechsel, J. Krysiak, S. Chamni, A. Weigert-Munoz, N. L. Harvey, D. Romo and S. A. Sieber

Chem. Commun., 2017, 53, 12818
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Mechanical insights into the regulation of programmed cell death by p53 via mitochondria

Kohji Yamada and Kiyotsugu Yoshida

Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, 2019, 1866, 839
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Fragment-based screening: A new paradigm for ligand and target discovery

Sinéad Knight, Davide Gianni and Adam Hendricks

SLAS Discovery, 2022, 27, 3
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Identification of Nogo-B as a potential therapeutic target of osteosarcoma via stereochemically selective covalent probes

Jian Xue, Meng Li, Li Kang, Meiting Wang, Jiabin Yin, Donghui Sun, Yaqi Deng, Qinghua Wei, Jiemin Wong, Tong Zhu and Shunying Liu

Cell Death Dis, 2025, 16
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Chemoproteomics-Enabled Covalent Ligand Screening Reveals a Thioredoxin-Caspase 3 Interaction Disruptor That Impairs Breast Cancer Pathogenicity

Kimberly E. Anderson, Milton To, James A. Olzmann and Daniel K. Nomura

ACS Chem. Biol., 2017, 12, 2522
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Covalent binding of withanolides to cysteines of protein targets

Christian Bailly

Biochemical Pharmacology, 2024, 226, 116405
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Click Chemistry in Proteomic Investigations

Christopher G. Parker and Matthew R. Pratt

Cell, 2020, 180, 605
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Site-Specific Activity-Based Protein Profiling Using Phosphonate Handles

Wouter van Bergen, Johannes F. Hevler, Wei Wu, Marc P. Baggelaar and Albert J.R. Heck

Molecular & Cellular Proteomics, 2023, 22, 100455
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Deubiquitinase-targeting chimeras for targeted protein stabilization

Nathaniel J. Henning, Lydia Boike, Jessica N. Spradlin, Carl C. Ward, Gang Liu, Erika Zhang, Bridget P. Belcher, Scott M. Brittain, Matthew J. Hesse, Dustin Dovala, Lynn M. McGregor, Rachel Valdez Misiolek, Lindsey W. Plasschaert, David J. Rowlands, Feng Wang, Andreas O. Frank, Daniel Fuller, Abigail R. Estes, Katelyn L. Randal, Anoohya Panidapu, Jeffrey M. McKenna, John A. Tallarico, Markus Schirle and Daniel K. Nomura

Nat Chem Biol, 2022, 18, 412
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Chemical Proteomics–Guided Discovery of Covalent Ligands for Cancer Proteins

Xiaoyu Zhang and Benjamin F. Cravatt

Annual Review of Cancer Biology, 2024, 8, 155
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Covalent targeting of the vacuolar H+-ATPase activates autophagy via mTORC1 inhibition

Clive Yik-Sham Chung, Hijai R. Shin, Charles A. Berdan, Breanna Ford, Carl C. Ward, James A. Olzmann, Roberto Zoncu and Daniel K. Nomura

Nat Chem Biol, 2019, 15, 776
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Comparative Shotgun Proteomics Reveals the Characteristic Protein Signature of Osteosarcoma Subtypes

Maram Alaa, Nouran Al-Shehaby, Ali Mostafa Anwar, Nesma Farid, Mustafa Shaban Shawky, Manal Zamzam, Iman Zaky, Ahmed Elghounimy, Shahenda El-Naggar and Sameh Magdeldin

Cells, 2023, 12, 2179
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Alkyl perchlorates in the Ritter-type reaction. Synthesis of N-alkylamides

N. V. Yashin, P. O. Markov, K. N. Sedenkova, D. A. Vasilenko, Yu. K. Grishin, T. S. Kuznetsova and E. B. Averina

Russ Chem Bull, 2020, 69, 980
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A Cyclopropene Electrophile that Targets Glutathione S‐Transferase Omega‐1 in Cells

Gustav J. Wørmer, Bente K. Hansen, Johan Palmfeldt and Thomas B. Poulsen

Angew Chem Int Ed, 2019, 58, 11918
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Proteomics in orthopedic research: Recent studies and their translational implications

George Li, Argyrios Stampas, Yoshihiro Komatsu, Xueqin Gao, Johnny Huard and Sheng Pan

Journal Orthopaedic Research, 2024, 42, 1631
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Identification of potential biomarkers associated with poor prognosis in oral squamous cell carcinoma through integrated bioinformatics analysis: A pilot study

Zeynab Bayat, Zohre Farhadi and Amir Taherkhani

Gene Reports, 2021, 24, 101243
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Platelet procoagulant phenotype is modulated by a p38-MK2 axis that regulates RTN4/Nogo proximal to the endoplasmic reticulum: utility of pathway analysis

Özgün Babur, Anh T. P. Ngo, Rachel A. Rigg, Jiaqing Pang, Zhoe T. Rub, Ariana E. Buchanan, Annachiara Mitrugno, Larry L. David, Owen J. T. McCarty, Emek Demir and Joseph E. Aslan

American Journal of Physiology-Cell Physiology, 2018, 314, C603
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Discovery of a Functional Covalent Ligand Targeting an Intrinsically Disordered Cysteine within MYC

Lydia Boike, Alexander G. Cioffi, Felix C. Majewski, Jennifer Co, Nathaniel J. Henning, Michael D. Jones, Gang Liu, Jeffrey M. McKenna, John A. Tallarico, Markus Schirle and Daniel K. Nomura

Cell Chemical Biology, 2021, 28, 4
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Cellular Exposure to Chloroacetanilide Herbicides Induces Distinct Protein Destabilization Profiles

Guy M. Quanrud, Ziqi Lyu, Sunil V. Balamurugan, Carolina Canizal, Hoi-Ting Wu and Joseph C. Genereux

ACS Chem. Biol., 2023, 18, 1661
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TEMPO Oxidative [3 + 2] Cycloaddition of N-Substituted Acrylamides and α-Diazoacetates: Access to Carbamoyl-Substituted Pyrazole-5-carboxylates

Lvyin Zheng, Beining Yang, Xiaoqing Zhu, Zhiying Zhang, Xiaofeng Hua, Peiyi Chen, Yinyun Lin and Wei Guo

J. Org. Chem., 2025, 90, 9903
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Harnessing the anti-cancer natural product nimbolide for targeted protein degradation

Jessica N. Spradlin, Xirui Hu, Carl C. Ward, Scott M. Brittain, Michael D. Jones, Lisha Ou, Milton To, Andrew Proudfoot, Elizabeth Ornelas, Mikias Woldegiorgis, James A. Olzmann, Dirksen E. Bussiere, Jason R. Thomas, John A. Tallarico, Jeffrey M. McKenna, Markus Schirle, Thomas J. Maimone and Daniel K. Nomura

Nat Chem Biol, 2019, 15, 747
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The McKenna reaction – avoiding side reactions in phosphonate deprotection

Katarzyna Justyna, Joanna Małolepsza, Damian Kusy, Waldemar Maniukiewicz and Katarzyna M Błażewska

Beilstein J. Org. Chem., 2020, 16, 1436
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Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway

Daniel Abegg, Martin Tomanik, Nan Qiu, Dany Pechalrieu, Anton Shuster, Bruno Commare, Antonio Togni, Seth B. Herzon and Alexander Adibekian

J. Am. Chem. Soc., 2021, 143, 20332
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Covalent Ligand Discovery against Druggable Hotspots Targeted by Anti-cancer Natural Products

Elizabeth A. Grossman, Carl C. Ward, Jessica N. Spradlin, Leslie A. Bateman, Tucker R. Huffman, David K. Miyamoto, Jordan I. Kleinman and Daniel K. Nomura

Cell Chemical Biology, 2017, 24, 1368
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Fragment-to-Lead Medicinal Chemistry Publications in 2017

Paul N. Mortenson, Daniel A. Erlanson, Iwan J. P. de Esch, Wolfgang Jahnke and Christopher N. Johnson

J. Med. Chem., 2019, 62, 3857
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Phosphorus fluoride exchange chemistry: An emerging strategy for covalent drug discovery

Shuyue Yang, Yongkuan Li, Lingyun Yang and Bingchen Yu

Tetrahedron Chem, 2025, 15, 100143
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A Cyclopropene Electrophile that Targets Glutathione S‐Transferase Omega‐1 in Cells

Gustav J. Wørmer, Bente K. Hansen, Johan Palmfeldt and Thomas B. Poulsen

Angewandte Chemie, 2019, 131, 12044
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Ligandability of E3 Ligases for Targeted Protein Degradation Applications

Bridget P. Belcher, Carl C. Ward and Daniel K. Nomura

Biochemistry, 2023, 62, 588
DOI: 10.1021/acs.biochem.1c00464

Palladium-Catalyzed Selective γ-Monoarylation of Free Amines Containing Symmetric γ-C–H Controlled by a Transient Directing Group

Sifan Dong, Xinghao Cai, Chen Ma, Haolong Li, Ying Kang, Juan Feng, Shiming Fan and Shouxin Liu

Org. Lett., 2024, 26, 6153
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Parthenolide Covalently Targets and Inhibits Focal Adhesion Kinase in Breast Cancer Cells

Charles A. Berdan, Raymond Ho, Haley S. Lehtola, Milton To, Xirui Hu, Tucker R. Huffman, Yana Petri, Chad R. Altobelli, Sasha G. Demeulenaere, James A. Olzmann, Thomas J. Maimone and Daniel K. Nomura

Cell Chemical Biology, 2019, 26, 1027
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Multiplexed Thiol Reactivity Profiling for Target Discovery of Electrophilic Natural Products

Caiping Tian, Rui Sun, Keke Liu, Ling Fu, Xiaoyu Liu, Wanqi Zhou, Yong Yang and Jing Yang

Cell Chemical Biology, 2017, 24, 1416
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Reticulon 4 in Breast Cancer: A Comprehensive Analysis of its Biomarker Potential for Prognosis, Immunology, and Drug Sensitivity

Tuğcan Korak and Murat Kasap

Braz. arch. biol. technol., 2025, 68
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STEFs: Activated Vinylogous Protein‐Reactive Electrophiles

Bente K. Hansen, Christopher J. Loveridge, Stine Thyssen, Gustav J. Wørmer, Andreas D. Nielsen, Johan Palmfeldt, Mogens Johannsen and Thomas B. Poulsen

Angewandte Chemie, 2019, 131, 3571
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RTN4 Knockdown Dysregulates the AKT Pathway, Destabilizes the Cytoskeleton, and Enhances Paclitaxel-Induced Cytotoxicity in Cancers

Gopal P. Pathak, Rashmi Shah, Barry E. Kennedy, J. Patrick Murphy, Derek Clements, Prathyusha Konda, Michael Giacomantonio, Zhaolin Xu, Isabel R. Schlaepfer and Shashi Gujar

Molecular Therapy, 2018, 26, 2019
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Chemoproteomics-Enabled Covalent Ligand Screening Reveals ALDH3A1 as a Lung Cancer Therapy Target

Jessica L. Counihan, Amanda L. Wiggenhorn, Kimberly E. Anderson and Daniel K. Nomura

ACS Chem. Biol., 2018, 13, 1970
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On the contribution of mass spectrometry-based platforms to the field of personalized oncology

Eleonora Orlando and Ruedi Aebersold

TrAC Trends in Analytical Chemistry, 2019, 110, 129
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Proteomics in Drug Development: The Dawn of a New Era?

Maria Frantzi, Agnieszka Latosinska and Harald Mischak

Proteomics Clinical Apps, 2019, 13
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Cell fate regulation by reticulon‐4 in human prostate cancers

Hu Zhao, Weipeng Su, Changyan Zhu, Tengyue Zeng, Shunliang Yang, Weizhen Wu and Dong Wang

Journal Cellular Physiology, 2019, 234, 10372
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Chemoproteomic-enabled phenotypic screening

Louis P. Conway, Weichao Li and Christopher G. Parker

Cell Chemical Biology, 2021, 28, 371
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NHS-Esters As Versatile Reactivity-Based Probes for Mapping Proteome-Wide Ligandable Hotspots

Carl C. Ward, Jordan I. Kleinman and Daniel K. Nomura

ACS Chem. Biol., 2017, 12, 1478
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Advanced Activity-Based Protein Profiling Application Strategies for Drug Development

Shan Wang, Yu Tian, Min Wang, Min Wang, Gui-bo Sun and Xiao-bo Sun

Front. Pharmacol., 2018, 9
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STEFs: Activated Vinylogous Protein‐Reactive Electrophiles

Bente K. Hansen, Christopher J. Loveridge, Stine Thyssen, Gustav J. Wørmer, Andreas D. Nielsen, Johan Palmfeldt, Mogens Johannsen and Thomas B. Poulsen

Angew Chem Int Ed, 2019, 58, 3533
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A Chemoproteomic Platform To Assess Bioactivation Potential of Drugs

Rui Sun, Fuguo Shi, Keke Liu, Ling Fu, Caiping Tian, Yong Yang, Keri A. Tallman, Ned A. Porter and Jing Yang

Chem. Res. Toxicol., 2017, 30, 1797
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Design, synthesis, in vitro and in silico evaluation of new 3-phenyl-4,5-dihydroisoxazole-5-carboxamides active against drug-resistant mycobacterium tuberculosis

Nikhil Baliram Gaikwad, Pathan Afroz, Mohammad Naiyaz Ahmad, Grace Kaul, Manjulika Shukla, Srinivas Nanduri, Arunava Dasgupta, Sidharth Chopra and Venkata Madhavi Yaddanapudi

Journal of Molecular Structure, 2021, 1227, 129545
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Covalent Ligand Screening Uncovers a RNF4 E3 Ligase Recruiter for Targeted Protein Degradation Applications

Carl C. Ward, Jordan I. Kleinman, Scott M. Brittain, Patrick S. Lee, Clive Yik Sham Chung, Kenneth Kim, Yana Petri, Jason R. Thomas, John A. Tallarico, Jeffrey M. McKenna, Markus Schirle and Daniel K. Nomura

ACS Chem. Biol., 2019, 14, 2430
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Proteome‐Wide Fragment‐Based Ligand and Target Discovery

Ines Forrest and Christopher G. Parker

Israel Journal of Chemistry, 2023, 63
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Covalent Targeting of Glutamate Cysteine Ligase to Inhibit Glutathione Synthesis**

Lydia H. Zhang, Michelle Tang, Xavier Tao, Qian Shao, Vienna Thomas, Saki Shimizu, Miki Kasano, Yoshinori Ishikawa, Takayuki Inukai and Daniel K. Nomura

ChemBioChem, 2023, 24
DOI: 10.1002/cbic.202300371

Activity-based protein profiling guided new target identification of quinazoline derivatives for expediting bactericide discovery

Jiao Meng, Ling Zhang, Xinxin Tuo, Yue Ding, Kunlun Chen, Mei Li, Biao Chen, Qingsu Long, Zhenchao Wang, Guiping Ouyang, Xiang Zhou and Song Yang

Journal of Advanced Research, 2025, 74, 57
DOI: 10.1016/j.jare.2024.10.002

E3 Ligases Meet Their Match: Fragment-Based Approaches to Discover New E3 Ligands and to Unravel E3 Biology

Iacovos N. Michaelides and Gavin W. Collie

J. Med. Chem., 2023, 66, 3173
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Applications of Activity‐Based Protein Profiling (ABPP) and Bioimaging in Drug Discovery

Jiaqian Xu, Xiaoqian Li, Ke Ding and Zhengqiu Li

Chemistry An Asian Journal, 2020, 15, 34
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Reimagining Druggability Using Chemoproteomic Platforms

Jessica N. Spradlin, Erika Zhang and Daniel K. Nomura

Acc. Chem. Res., 2021, 54, 1801
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Chemical Proteomic Characterization of a Covalent KRASG12C Inhibitor

Aruna Wijeratne, Junpeng Xiao, Christopher Reutter, Kelly W. Furness, Rebecca Leon, Mohammad Zia-Ebrahimi, Rachel N. Cavitt, John M. Strelow, Robert D. Van Horn, Sheng-Bin Peng, David A. Barda, Thomas A. Engler and Michael J. Chalmers

ACS Med. Chem. Lett., 2018, 9, 557
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APD-Containing Cyclolipodepsipeptides Target Mitochondrial Function in Hypoxic Cancer Cells

Kristian Mark Jacobsen, Nikolaj Lilholm Villadsen, Thomas Tørring, Camilla Bak Nielsen, Trine Salomón, Morten Muhlig Nielsen, Michail Tsakos, Christian Sibbersen, Carsten Scavenius, Rikke Nielsen, Erik Ilsø Christensen, Paula Fernandez Guerra, Peter Bross, Jakob Skou Pedersen, Jan Johannes Enghild, Mogens Johannsen, Jørgen Frøkiær, Jens Overgaard, Michael R. Horsman, Morten Busk and Thomas B. Poulsen

Cell Chemical Biology, 2018, 25, 1337
DOI: 10.1016/j.chembiol.2018.07.010

N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics

Tin-Yan Koo, Hinyuk Lai, Daniel K. Nomura and Clive Yik-Sham Chung

Nat Commun, 2023, 14
DOI: 10.1038/s41467-023-39268-w

The putative oncogenic role of WDTC1 in colorectal cancer

Xiaoyu Wang, Qiuyin Cai, Jie Ping, Hector Diaz-Zabala, Yumin Xia and Xingyi Guo

Carcinogenesis, 2022, 43, 594
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DNA damage triggers tubular endoplasmic reticulum extension to promote apoptosis by facilitating ER-mitochondria signaling

Pengli Zheng, Qingzhou Chen, Xiaoyu Tian, Nannan Qian, Peiyuan Chai, Bing Liu, Junjie Hu, Craig Blackstone, Desheng Zhu, Junlin Teng and Jianguo Chen

Cell Res, 2018, 28, 833
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Covalent-Fragment Screening of BRD4 Identifies a Ligandable Site Orthogonal to the Acetyl-Lysine Binding Sites

Michael D. Olp, Daniel J. Sprague, Christopher J. Goetz, Stefan G. Kathman, Sarah L. Wynia-Smith, Shifali Shishodia, Steven B. Summers, Ziyang Xu, Alexander V. Statsyuk and Brian C. Smith

ACS Chem. Biol., 2020, 15, 1036
DOI: 10.1021/acschembio.0c00058