Issue 3, 2024

H2O2-stimulated Janus-shaped self-propelled nanomotors as an active treatment for acute renal injury

Abstract

As emerging nanosystems, nanomotors have been applied in the active treatment of many diseases. In this paper, Pt@chitosan-loaded melatonin asymmetrical nanomaterials embedded with L-serine (S, kidney injury molecule 1-targeting agent) were constructed to alleviate acute kidney injury (AKI). The Janus nanocarriers arrived at the renal injury site via the bloodstream and exhibited high permeability. Because of melatonin distribution in the kidneys combined with H2O2-stimulated O2 release, the administration of the Janus nanosystem resulted in active treatment through the motion of nanomotors by asymmetrical O2 release.

Graphical abstract: H2O2-stimulated Janus-shaped self-propelled nanomotors as an active treatment for acute renal injury

Supplementary files

Article information

Article type
Paper
Submitted
23 Sept. 2023
Accepted
07 Nov. 2023
First published
21 Dec. 2023

Nanoscale, 2024,16, 1282-1290

H2O2-stimulated Janus-shaped self-propelled nanomotors as an active treatment for acute renal injury

J. Xu, Y. Zhong, W. Wang, R. Gao, Y. Wang, F. Tong, J. Sun, M. Hong, L. Qiao, W. Qiao, Q. Mei and J. Wu, Nanoscale, 2024, 16, 1282 DOI: 10.1039/D3NR04808J

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements