Issue 2, 2024

Efficient post-synthesis incorporation and conjugation of reactive ketones in RNA via 2′-acylation

Abstract

Despite the broad utility of ketones in bioconjugation, few methods exist to introduce them into RNA. Here we develop highly reactive 2′-OH acylating reagents containing strained-ring ketones, and employ them as versatile labeling handles for RNA.

Graphical abstract: Efficient post-synthesis incorporation and conjugation of reactive ketones in RNA via 2′-acylation

Supplementary files

Article information

Article type
Communication
Submitted
18 Okt. 2023
Accepted
21 Nov. 2023
First published
29 Nov. 2023

Chem. Commun., 2024,60, 232-235

Efficient post-synthesis incorporation and conjugation of reactive ketones in RNA via 2′-acylation

R. Shioi, L. Xiao, L. Fang and E. T. Kool, Chem. Commun., 2024, 60, 232 DOI: 10.1039/D3CC05123D

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements