Issue 9, 2024

Emerging nanoparticle platforms for CpG oligonucleotide delivery

Abstract

Unmethylated cytosine–phosphate–guanine (CpG) oligodeoxynucleotides (ODNs), which were therapeutic DNA with high immunostimulatory activity, have been applied in widespread applications from basic research to clinics as therapeutic agents for cancer immunotherapy, viral infection, allergic diseases and asthma since their discovery in 1995. The major factors to consider for clinical translation using CpG motifs are the protection of CpG ODNs from DNase degradation and the delivery of CpG ODNs to the Toll-like receptor-9 expressed human B-cells and plasmacytoid dendritic cells. Therefore, great efforts have been devoted to the advances of efficient delivery systems for CpG ODNs. In this review, we outline new horizons and recent developments in this field, providing a comprehensive summary of the nanoparticle-based CpG delivery systems developed to improve the efficacy of CpG-mediated immune responses, including DNA nanostructures, inorganic nanoparticles, polymer nanoparticles, metal–organic-frameworks, lipid-based nanosystems, proteins and peptides, as well as exosomes and cell membrane nanoparticles. Moreover, future challenges in the establishment of CpG delivery systems for immunotherapeutic applications are discussed. We expect that the continuously growing interest in the development of CpG-based immunotherapy will certainly fuel the excitement and stimulation in medicine research.

Graphical abstract: Emerging nanoparticle platforms for CpG oligonucleotide delivery

Article information

Article type
Review Article
Submitted
02 Dec. 2023
Accepted
15 Janv. 2024
First published
16 Janv. 2024

Biomater. Sci., 2024,12, 2203-2228

Emerging nanoparticle platforms for CpG oligonucleotide delivery

M. Li, H. Yao, K. Yi, Y. Lao, D. Shao and Y. Tao, Biomater. Sci., 2024, 12, 2203 DOI: 10.1039/D3BM01970E

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