Issue 6, 2024

Gallic acid: design of a pyrogallol-containing hydrogel and its biomedical applications

Abstract

Polyphenol hydrogels have garnered widespread attention due to their excellent adhesion, antioxidant, and antibacterial properties. Gallic acid (GA) is a typical derivative of pyrogallol that is used as a hydrogel crosslinker or bioactive additive and can be used to make multifunctional hydrogels with properties superior to those of widely studied catechol hydrogels. Furthermore, compared to polymeric tannic acid, gallic acid is more suitable for chemical modification, thus broadening its range of applications. This review focuses on multifunctional hydrogels containing GA, aiming to inspire researchers in future biomaterial design. We first revealed the interaction mechanisms between GA molecules and between GA and polymers, analyzed the characteristics GA imparts to hydrogels and compared GA hydrogels with hydrogels containing catechol. Subsequently, in this paper, various methods of integrating GA into hydrogels and the applications of GA in biomedicine are discussed, finally assessing the current limitations and future development potential of GA. In summary, GA, a natural small molecule polyphenol with excellent functionality and diverse interaction modes, has great potential in the field of biomedical hydrogels.

Graphical abstract: Gallic acid: design of a pyrogallol-containing hydrogel and its biomedical applications

Article information

Article type
Review Article
Submitted
26 Nov. 2023
Accepted
06 Febr. 2024
First published
08 Febr. 2024

Biomater. Sci., 2024,12, 1405-1424

Gallic acid: design of a pyrogallol-containing hydrogel and its biomedical applications

W. Weian, Y. Yunxin, W. Ziyan, J. Qianzhou and G. Lvhua, Biomater. Sci., 2024, 12, 1405 DOI: 10.1039/D3BM01925J

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements